Search results for "Sclerosis"

Unmet needs and gaps in the identification of secondary progression in multiple sclerosis: a Southern Italy healthcare professionals' perspective

2022

Abstract Objective Multiple sclerosis (MS) is a chronic disease with different clinical courses and a tendency to worsening. The relapsing–remitting MS presents acute onset and relapses of neurological symptoms, followed by their remission. This form can convert to secondary progressive MS (SPMS) with irreversible neurological worsening and disability. The identification of signs, symptoms, markers of progression, and strategies to manage MS patients is mandatory to allow early identification of those at higher risk of conversion to SPMS, for prompt intervention to cope with the progression of the disease. Methods A panel of Italian experts from Southern Italy have reviewed the current know…

Selected psychometric aspects of the Polish version of the Liverpool Self-efficacy Scale

2020

BackgroundSelf-efficacy expresses the individual’s belief in their ability to take up and continue actions in order to achieve a particular result and cope with various life events. For people with multiple sclerosis (MS), self-efficacy is an im-portant resource because it affects how they adapt to the disease, and influences their motivation, health-related behavior and physical activity. It also has a great impact on their quality of life. Because of the lack of tools for meas-uring self-efficacy in Polish patients with multiple sclerosis, the goal of the current study was to develop a Polish language version of the Liverpool Self-efficacy Scale (LSES) and assess its validity and reliabil…

Hsp60 and human aging: Les liaisons dangereuses 

2013

Stressors can cause abnormal intracellular accumulation of Hsp60 and its localization in extramitochondrial sites, secretion, and circulation, with immune system activation. Dysfunction of chaperones associated with their quantitative and qualitative decline with aging (chaperonopathies of aging) characterizes senescence and is a potential causal factor in the physiological deterioration that occurs with it. The role of Hsp60 in aging is not easy to elucidate, because aging is accompanied by pathologies (e.g., cardiovascular and neurodegenerative disorders, osteoporosis, diabetes, cancer, etc.) in which Hsp60 has been implicated but, although those disorders are more frequent in the elderly…

Zymographic Analysis of Matrix Metalloproteinases (MMP-2 and MMP-9) in Cerebrospinal Fluid and Sera from Patients with Multiple Sclerosis

2023

Blood lipid, homocysteine, uric acid and vitamins in clinically stable Multiple Sclerosis patients

2008

A decrease of antioxidants, of neuroprotective and immunoregulatory vitamins and an increase of total-Homocysteine, Cholesterol, HDL-cholesterol, and of cellular stress markers [1] was reported in patients affected by Multiple Sclerosis. Recently, considering their unreliability, mainly due to the variability of the samples investigated, the attention focused on clinical relapse that results associated to a decrease of Uric acid and an increase of Cholesterol and stress markers. Aim. To identify the biochemical status during Multiple Sclerosis (MS) in a phase of clinical stability (PCS), we compared the blood levels of Urico acid (UA), Folic acid (FA), vitamins B12, A, and E, total-Homocyst…

MULTIPLE SCLEROSIS: PHYSICAL ACTIVITY AND WELL-BEING

2017

Multiple sclerosis (MS) is a chronic disease that affects central nervous system (CNS) – coexists in brain, spinal cord and optic nerves. It can process in three different courses: remitting, progressive and progressive-relapsing. Although there is still no cure for MS, effective strategies are available to modify the disease course, reduce number of relapses, rate of progressions and development of new lesions. Nowadays, moderate physical performance is strongly recommended: besides having positive effects on the body, it can have a positive effect on the psychophysical wellbeing. Essentially there are 3 types of training protocols: aerobic (endurance training), strength training (resistan…

Atrial natriuretic factor,but non oxytocin, presence in atherosclerotic plaques of human common carotid arteries

2009

ANP immunolocalization in internal carotid artery wall of subjects with and without atherosclerotic lesions

2008

Gli aneurismi dell'aorta addominale

2009

Not available

RUOLO DELL’ESERCIZIO FISICO NELLA QUALITÀ DI VITA DI SOGGETTI CON SCLEROSI MULTIPLA. ROLE OF EXERCISE IN THE QUALITY OF LIFE IN SUBJECTS WITH MULTIPL…

2012

La sclerosi multipla è una patologia neurodegenerativa cronica che ha un impatto considerevole sullo stato fisico, psicologico e sociale dei pazienti, influenzando negativamente la loro qualità di vita. Tra i fattori contribuenti ad una ridotta qualità di vita sono inclusi la presenza di dolore, spasmi, sindromi depressive, l’aumento della fatica e la riduzione della forza muscolare, mobilità ed autonomia nella deambulazione. Accanto alla medicina convenzionale, varie forme di medicina complementare ed alternativa, tra cui l’esercizio fisico, sono utilizzate dai soggetti con sclerosi multipla. Tuttavia, poche sono le prove scientifiche a sostegno della loro efficacia nel ridurre i sintomi d…