Search results for "Secondary"
showing 10 items of 1765 documents
Extracellular Domains of the Bradykinin B2 Receptor Involved in Ligand Binding and Agonist Sensing Defined by Anti-peptide Antibodies
1996
Many of the physiological functions of bradykinin are mediated via the B2 receptor. Little is known about binding sites for bradykinin on the receptor. Therefore, antisera against peptides derived from the putative extracellular domains of the B2 receptor were raised. The antibodies strongly reacted with their corresponding antigens and cross-reacted both with the denatured and the native B2 receptor. Affinity-purified antibodies to the various extracellular domains were used to probe the contact sites between the receptor and its agonist, bradykinin or its antagonist HOE140. Antibodies to extracellular domain 3 (second loop) efficiently interfered, in a concentration-dependent manner, with…
Corrigendum to “Conservation value of forest plantations for bird communities in western Kenya” [Forest Ecol. Manag. 255 (2008) 3885–3892]
2009
A re-analysis of the bird data revealed a mistake within the database query. Only bird individuals that were heard were integrated in the results leading to lower total richness and number of individuals. In total 115 species and 13,331 individuals were detected of which 41 were forest specialists (43% of all individuals), 40 forest generalists (41%) and 34 forest visitors (16%). The statistical analyses remain very similar. We recorded significant differences in mean bird species richness, number of individuals and relative species richness among the five forest types (Table 1). Multiple pairwise comparisons showed significantly higher numbers of species in natural forest, mixed indigenous…
Propagation of Calendula maritima Guss. (Asteraceae) through Biotechnological Techniques for Possible Usage in Phytotherapy
2022
The genus Calendula (Asteraceae) includes several species that are renowned for their therapeutic properties and/or use as ingredients in the preparation of cosmetics. The rare and critically endangered sea marigold, Calendula maritima Guss., an endemic species from Western Sicily, has also been recognized as a potential “farm plant species” for several important compounds used in cosmetics. However, the few remnant populations of this species are currently threatened with extinction because of several factors, such as hybridization with the congeneric species Calendula suffruticosa subsp. fulgida (Raf.) Guadagno and anthropogenic disturbance of its habitat. Therefore, in order to preserve …
Products of snowflaked Euclidean lines are not minimal for looking down
2017
We show that products of snowflaked Euclidean lines are not minimal for looking down. This question was raised in Fractured fractals and broken dreams, Problem 11.17, by David and Semmes. The proof uses arguments developed by Le Donne, Li and Rajala to prove that the Heisenberg group is not minimal for looking down. By a method of shortcuts, we define a new distance $d$ such that the product of snowflaked Euclidean lines looks down on $(\mathbb R^N,d)$, but not vice versa.
Competence analysis of an open modelling task
2015
[ES] Según diversos autores, las actividades dirigidas al desarrollo conjunto de las competencias matemáticas deben relacionarse con la realidad y los procesos de modelización matemática. El objetivo del presente trabajo es describir, a partir de la producción de un grupo de alumnos de tercer curso de ESO, las competencias que los alumnos han de poner en juego para resolver una tarea genuina y completa de modelización y que formarían parte de la propia competencia en Modelización.
Rank two aCM bundles on the del Pezzo fourfold of degree 6 and its general hyperplane section
2018
International audience; In the present paper we completely classify locally free sheaves of rank 2 with vanishing intermediate cohomology modules on the image of the Segre embedding $\mathbb{P}^2$ x $\mathbb{P}^2 \subseteq \mathbb{P}^8$ and its general hyperplane sections.Such a classification extends similar already known results regarding del Pezzo varieties with Picard numbers 1 and 3 and dimension at least 3.
Existence of dynamical low-rank approximations to parabolic problems
2021
The existence and uniqueness of weak solutions to dynamical low-rank evolution problems for parabolic partial differential equations in two spatial dimensions is shown, covering also non-diagonal diffusion in the elliptic part. The proof is based on a variational time-stepping scheme on the low-rank manifold. Moreover, this scheme is shown to be closely related to practical methods for computing such low-rank evolutions.
SLIT's Prevention of the Allergic March.
2018
PURPOSE OF REVIEW: The progression of atopic disorders from atopic dermatitis in infants to allergic rhinitis and asthma in children, adolescents, and adults defines the allergy march. Allergen immunotherapy is the only causal treatment altering the immunological mechanism underlying the allergic diseases. The sublingual administration route is more acceptable than the subcutaneous one in pediatric age. RECENT FINDINGS: Several studies show the efficacy and safety profile of sublingual immunotherapy (SLIT) for the treatment of respiratory allergy diseases, but few data are available on its effect of primary and secondary prevention of allergic disease. The purpose of this manuscript is to r…
Amyloid Fibrils Formation of Concanavalin A at Basic pH
2011
Mechanisms of partial unfolding and aggregation of proteins are of extreme interest in view of the fact that several human pathologies are characterized by the formation and deposition of protein-insoluble material, mainly composed of amyloid fibrils. Here we report on an experimental study on the heat-induced aggregation mechanisms, at basic pH, of concanavalin A (ConA), used as a model system. Thioflavin T (ThT) fluorescence and multiangle light scattering allowed us to detect different intertwined steps in the formation of ConA aggregates. In particular, the ThT fluorescence increase, observed in the first phase of aggregation, reveals the formation of intermolecular β-sheet structure wh…
Decoding vibrational states of Concanavalin A amyloid fibrils.
2015
International audience; Amyloid and amyloid-like fibrils are a general class of protein aggregates and represent a central topic in life sciences for their involvement in several neurodegenerative disorders and their unique mechanical and supramolecular morphological properties. Both their biological role and their physical properties, including their high mechanical stability and thermodynamic inertia, are related to the structural arrangement of proteins in the aggregates at molecular level. Significant variations may exist in the supramolecular organization of the commonly termed cross-β structure that constitutes the amyloid core. In this context, a fine knowledge of the structural deta…