Search results for "Semi"

Potential myocardial iron content evaluation by magnetic resonance imaging in thalassemia major patients treated with Deferoxamine or Deferiprone dur…

2003

The purpose of this study was to evaluate if the variations of heart magnetic resonance imaging in beta-thalassemia major patients treated with Deferoxamine B mesylate (DF) or Deferiprone (L1) chelation therapy is a useful tool of the indirect myocardial iron content determination. For this reason, a prospective study was carried out. Seventy-two consecutive patients with beta-thalassemia major (35 treated with DF and 37 with L1) were studied. The main outcome results were laboratory parameters including determination of the liver iron concentration (LIC) and magnetic resonance imaging (MRI) of the heart and liver. The heart to muscle signal intensity ratios (HSIRs) were significantly incre…

Role of hypogonadism in development of bone alterations in thalassemic patients

2005

Although transfusions and chelation therapy have improved survival of patients afflicted with Thalassemia Major (TM), endocrine alterations are still common complications. Particularly, hypogonadism plays an important role in the aetiology of osteoporosis in these patients. It is clear that in most patients the gonadal failure is a consequence of a pituitary damage and that a hypogonadotropic hypogonadism occurs; nevertheless, also a gonadal damage because of iron deposition may be a further cause of hypogonadism. Prevalence of the pubertal failure ranges between 50 to 80% of the cases. In some studies ferritin levels have been correlated with hypogonadism, suggesting that improvement of ch…

Treatment of hepatitis C virus infection with direct-acting antiviral drugs is safe and effective in patients with hemoglobinopathies.

2017

Role of osteoprotegerin in the pathogenesis of thalassemia induced osteoporosis

2006

A Particular Focus on the Prevalence of α- and β-Thalassemia in Western Sicilian Population from Trapani Province in the COVID-19 Era

2023

Thalassemia is a Mendelian inherited blood disease caused by α- and β-globin gene mutations, known as one of the major health problems of Mediterranean populations. Here, we examined the distribution of α- and β-globin gene defects in the Trapani province population. A total of 2,401 individuals from Trapani province were enrolled from January 2007 to December 2021, and routine methodologies were used for detecting the α- and β-globin genic variants. Appropriate analysis was also performed. Eight mutations in the α globin gene showed the highest frequency in the sample studied; three of these genetic variants represented the 94% of the total α-th…

Latvijas Vēstures Institūta Žurnāls. 2020, Nr. 2 (112)

2020

Émile Zola et la question juive avant l'affaire Dreyfus

2017

Emile Zola’s article entitled I accuse...! (1898), accusing the French government of anti-Semitism, has been considered since its publication as a decisive voice defending not only the rights of a particular Jew, but also, in a larger context, truth, morality and justice. However, the “Jewish question” was already important for Zola before writing this text, and some subjects concerning Jews and their social perception occur as well in the Rougon-Macquart cycle as in journalistic chronicles written by the author. The paper examines the ways in which the “Jewish question” appears in Zola’s various texts.

Roland Barthes. El sentido de la moda

2021

Roland Barthes devoted much of his intellectual interest to the phenomenon of fashion. Long before his famous Système de la Mode, he wrote numerous essays on the subject, mainly of a methodological nature, both to elaborate a coherent historiography of dress and to establish a semiology of dress itself, distinguishing –with Saussure– between costume (langue) and clothing (parole). Indeed, if dress is a heteroclite whole, like language for Saussure, the semiologist’s task is to reconstruct its functioning as a system of signs, not only in the dress described by the magazines (as he does in Système), but also in the dress actually worn. A set of essays, in short, of extreme importance for any…

Polish contemporary art to the anti-semitism of Poles and its political significance

2016

Abstract This article presents artistic creativity which worked through the problem of Polish anti-Semitism. Almost all discussed works, performances, films, projects appeared after 2000, when Jan Tomasz Gross published his book Neighbors, in which he described the massacre in the village of Jedwabne (1941) launching a public debate about the responsibility of Poles in the Holocaust of the Jews. In the text, I showed as art, which is conventionally called “post-Jedwabne” was part of this debate. Its political status on possibly general level was associated primarily with the revision of conventionalized historical memory and national identity formed on romantic patterns. The text shows that…

A competitive reactivity study on the oxidative cyclization of thiosemicarbazones into 1,3,4-thiadiazoles

2022

Abstract In order to obtain useful insights on the mechanism of formation of 2(3H)-imino-1,3,4-thiadiazoles by oxidative cyclization of aldehyde thiosemicarbazones with Cu(II) or Fe(III) salts, a competitive reactivity study was performed on a suitable set of diversely substituted substrates, by means of HPLC techniques. This approach enabled to exploit Hammett’s equation without performing otherwise difficult-to-run kinetic experiments. The results presented herein support the hypothesis that the formation of the thiadiazole ring is induced by the attack of the oxidizing Lewis acid metal cation onto the imine-like nitrogen atom of the thiosemicarbazone substrate. Beyond mechanistic interpr…