Search results for "Semicarbazone"
showing 3 items of 23 documents
H2-Antihistaminika, 32. Mitt. Synthese und H2-antagonistische Wirkung von N-[3-(3-Piperidino-methyl-phenoxy)propyl]-1.3.4-oxadiazol-2-aminen
1986
Es wird uber die Synthese und H2-antagonistische Wirksamkeit von N-[3-(3-Piperidinomethyl-phenoxy)-propyl]-1.3.4-oxadiazol-2-amin und dessen 5-substituierte Derivate berichtet. H2-Antihistaminics, XXXII: Synthesis and H2-Antagonistic Activity of N-[3-(3-(Piperidinomethyl)phenoxy)propyl]- 1.3.4-oxadiazol-2-amines The synthesis and H2-antagonistic activity of N-[3-(3-(piperidinomethyl)phenoxy)propyl]-l.3.4-oxadiazol-2-amine and its 5-substituted derivatives are reported.
Synthesis, crystal structure and Hirshfeld analysis of a crystalline compound comprising a 1/1 mixture of 1-[(1R,4S)- and 1-[(1S,4R)-1,7,7-trimethyl-…
2020
A racemic mixture of (R)- and (S)-camphor thiosemicarbazone, which crystallizes in the centrosymmetric space group C2/c, is reported.
A competitive reactivity study on the oxidative cyclization of thiosemicarbazones into 1,3,4-thiadiazoles
2022
Abstract In order to obtain useful insights on the mechanism of formation of 2(3H)-imino-1,3,4-thiadiazoles by oxidative cyclization of aldehyde thiosemicarbazones with Cu(II) or Fe(III) salts, a competitive reactivity study was performed on a suitable set of diversely substituted substrates, by means of HPLC techniques. This approach enabled to exploit Hammett’s equation without performing otherwise difficult-to-run kinetic experiments. The results presented herein support the hypothesis that the formation of the thiadiazole ring is induced by the attack of the oxidizing Lewis acid metal cation onto the imine-like nitrogen atom of the thiosemicarbazone substrate. Beyond mechanistic interpr…