Search results for "Sensitivity"
showing 10 items of 3059 documents
Clozapine-related drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a systematic review.
2020
The Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a severe, multiorganic, and potentially life-threatening drug-induced hypersensitivity reaction, linked to several common drugs, including antiepileptics, antibiotics, and several psychotropic drugs, including clozapine. Due to the importance of clozapine in the management of treatment-resistant schizophrenia, a systematic review and characterization of clozapine-related DRESS syndrome is long overdue.This systematic review was conducted following PRISMA guidelines. PubMed, Embase, PsychINFO, and the Cochrane Library databases were independently reviewed up to 1 November 2019 for articles reporting clozapine-relat…
Diagnostic Accuracy of a New Antigen Test for SARS-CoV-2 Detection
2021
Background and aims: Quick and reliable diagnostic tools play an important role in controlling the spread of the SARS-Cov-2 pandemic. The aim of this study was to evaluate the diagnostic accuracy of a new cyto-salivary antigen test aimed at detecting the presence of antigens for SARS-CoV-2, as compared by the gold standard RT-PCR and a lateral flow test. Methods: A total of 433 healthy volunteers were enrolled in the study and the sensitivity and specificity of the new cyto-salivary antigen test were calculated, as compared to the RT-PCR nasopharyngeal swab and to the lateral flow test. Results: A total of 433 samples were collected and tested at the Mediterranean Fair in Palermo from Febru…
Validity and repeatability of the Pediatric Allergy Questionnaire for Athletes (AQUAped) for the screening of atopy.
2020
BACKGROUND High atopy prevalence has been reported in athletes. Having an age-specific questionnaire for predicting atopy is important for an optimal management of young athletes. The study objectives were as follows: (i) developing a scoring system for the Pediatric Allergy Questionnaire for Athletes (AQUAped); (ii) identifying the optimal age target within the range 7-14 years; (iii) assessing AQUAped validity and repeatability in the identified target population. METHODS A total of 133 young athletes (age 7-14 years) were recruited. Following a screening visit, the participants filled AQUAped at baseline (T0) and after 7 days (T1), concomitantly undergoing skin prick testing. Using atopy…
Use of a three-factor interpretive optimisation strategy in the development of an isocratic chromatographic procedure for the screening of diuretics …
2000
Screening of diuretics in urine is feasible through direct injection of the samples into the chromatographic system and isocratic reversed-phase liquid chromatography (RPLC) with micellar-organic mobile phases of sodium dodecyl sulfate (SDS) and 1-propanol. The surfactant coverage of the chromatographic column makes the addition of organic competing amines less necessary than in conventional aqueous-organic RPLC to achieve well-shaped peaks. Also, the range of elution strengths of micellar mobile phases required to elute mixtures of hydrophobic and hydrophilic diuretics is smaller. This allows the isocratic separation of the diuretics within adequate analysis times. An interpretive methodol…
Comparison of adjuvant and adjuvant-free murine experimental asthma models
2009
Introduction The most widely used protocol for the induction of experimental allergic airway inflammation in mice involves sensitization by intraperitoneal (i.p.) injections of the antigen ovalbumin (OVA) used in conjunction with the adjuvant aluminium hydroxide (alum). Although adjuvants are frequently used, there are questions regarding the necessity of alum for murine asthma studies due to the non-physiological nature of this chemical. Objective The objective of this study was to compare experimental asthma phenotypes between adjuvant and adjuvant-free protocols of murine allergic airway inflammation in an attempt to develop a standardized alternative to adjuvant use. Method An adjuvant-…
Analytical model for the long- distance tracer-transport in plants
2011
International audience; Recent investigations of long-distance transport in plants using non-invasive tracer techniques such as C radiolabeling monitored by positron emission tomography (PET) combined with magnetic resonance imaging (MRI) revealed the need of dedicated methods to allow a quantitative data analysis and comparison of such experiments. A mechanistic compartmental tracer transport model is presented, defined by a linear system of partial differential equations (PDEs). This model simplifies the complexity of axial transport and lateral exchanges in the transport pathways of plants (e.g. the phloem) by simulating transport and reversible exchange within three compartments using j…
Walking Stroop carpet: an innovative dual-task concept for detecting cognitive impairment
2013
A Perrochon,1,2,5 G Kemoun,1,2 E Watelain,3,4 A Berthoz51ISIS, Research Institute on Handicap and Aging, Paris; 2Université de Poitiers, Laboratoire Mobilité, Vieillissement et Exercice (MOVE), EA 6314, 3Université de Valenciennes, LAMIH, UMR CNRS 8201, 4Université Sud Toulon Var, HandiBio, EA 4322, La Garde, 5LPPA, UMR CNRS 7152, Collège de France, Paris, FranceBackground: Several studies have reported the potential value of the dual-task concept during locomotion in clinical evaluation because cognitive decline is strongly associated with gait abnormalities. However, current dual-task tests appear to be insufficient for early diagnosi…
A person-oriented approach to diary data. Children’s temperamental negative emotionality increases susceptibility to emotion transmission in father-c…
2015
The notion that some individuals are more prone to emotion transmission than others has prompted the need for a person-oriented approach to emotion transmission in parent-child dyads. The present study applied a person-oriented analysis to examine the patterns of emotion transmission that can be identified in the diary data of father-child dyads, and the extent to which children with high levels of temperamental negative emotionality are particularly susceptible to emotion transmission within the family. Mothers of 149 first grade children (age 6 to 7) completed questionnaires concerning their child’s temperament. Mothers and fathers maintained diary questionnaires (for a total of 7 days) c…
”Do you have a language of emotions?” : early multilinguals' perceptions of emotional weight in their languages
2017
Monikielisyys on tänä päivänä hyvin yleinen ilmiö, jota on tutkittu monista näkökulmista. Yksi suosittu aihe on monikielisten henkilöiden omiin kieliinsä yhdistämät tunnemerkitykset, eli kuinka jotkut kielet voidaan kokea tunnetasolla painoltaan tai merkitykseltään voimakkaampina kuin toiset. Tämä tunneherkkyys on yleisesti ottaen vahvin henkilön äidinkielessä, mutta niille puhujille, joilla ei ole yhtä selvää äidinkieltä, tilanne on toinen. Tämän tutkielman tavoitteena oli selvittää, kokevatko tällaiset hyvin varhaiset monikieliset puhujat, että jokin heidän kielistään on selvästi emotionaalisemmalta painoarvoltaan selkeämpi kuin muut, tai onko heillä kieli, jonka voisi luokitella tunteide…
Implementation of sparse forward mode automatic differentiation with application to electromagnetic shape optimization
2011
In this paper, we present the details of a simple lightweight implementation of the so-called sparse forward mode automatic differentiation (AD) in the C++programming language. Our implementation and the well-known ADOL-C tool (which utilizes taping and compression techniques) are used to compute Jacobian matrices of two nonlinear systems of equations from the MINPACK-2 test problem collection. Timings of the computations are presented and discussed. Moreover, we perform the shape sensitivity analysis of a time-harmonic Maxwell equation solver using our implementation and the tapeless mode of ADOL-C, which implements the dense forward mode AD. It is shown that the use of the sparse forward …