Search results for "Senso"

Synthesis of insulin and its effects in Y79 human retinoblastoma cells

1994

This paper demonstrates that Y79 human retinoblastoma cells contain immunoreactive insulin (IRI) and release it in the medium. Cells cultured either in suspension or in monolayer showed a similar content of IRI. Moreover, in both conditions, IRI concentration was higher in cells cultured in serum-supplemented medium rather than in serum-free medium. Retinoblastoma cells are capable of synthesizing insulin. This was demonstrated by incubating Y79 cells with [3H]leucine. The synthesized radioactive insulin was separated and assayed by means of a HPLC procedure described in this paper. Both cell growth and [3H]thymidine and [3H]uridine incorporation into acid-insoluble fraction was reduced (-7…

Plasmalogens and cell‐cell communication between retinal glial cells

2017

National audience; Purpose Plasmalogens are glycerophospholipids containing a vinyl‐ether bond at sn‐1 position of their glycerol backbone and polyunsaturated fatty acids (PUFAs) at sn‐2. We have previously shown that plasmalogens are involved in the regulation of perinatal retinal vascular development and particularly in astrocyte template formation (Saab et al, PLoSONE 2012 9(6):e101076). Since retinal Müller cells and astrocytes can communicate through calcium waves and connexin 43‐rich gap junctions, the aim of our study was to determine whether a reduction of plasmalogen levels affects communication between retinal glial cells. Methods Primary Müller cells and astrocyte were isolated f…

Adhesive papillae ofAscidia malacaswimming larvae: investigations on their sensory function

1999

Summary Swimming larvae of Ascidia malaca bear, in the anterior region of cephalenteron, three adhesive papillae through which they can attach to a substratum prior to metamorphosis. The ultrastructural investigations described in the present work have mainly revealed the presence of three cell types constituting the papillae: (a) collocytes, (b) axial columnar cells, (c) sensory cells. Collocytes, whose ultrastructure is typical of secretory cells, form the adhesive secretion. The ultrastructural observations of the axial columnar cells are insufficient to explain their function. Probably this cell type plays a supporting role though some sensory function cannot be excluded due to the pres…

Neocortical Layer 6B as a Remnant of the Subplate - A Morphological Comparison.

2015

The fate of the subplate (SP) is still a matter of debate. The SP and layer 6 (which is ontogenetically the oldest and innermost neocortical lamina) develop coincidentally. Yet, the function of sublamina 6B is largely unknown. It has been suggested that it consists partly of neurons from the transient SP, however, experimental evidence for this hypothesis is still missing. To obtain first insights into the neuronal complement of layer 6B in the somatosensory rat barrel cortex, we used biocytin stainings of SP neurons (aged 0-4 postnatal days, PND) and layer 6B neurons (PND 11-35) obtained during in vitro whole-cell patch-clamp recordings. Neurons were reconstructed for a quantitative charac…

Oxysterols: Influence on plasma membrane rafts microdomains and development of ocular diseases

2015

Oxidation of cholesterol into oxysterols is a major way of elimination of cholesterol from the liver and extrahepatic tissues, including the brain and the retina. Oxysterols are involved in various cellular processes. Numerous links have been established between oxysterols and several disorders such as neurodegenerative pathologies, retinopathies and atherosclerosis. Different components of the lipid layer such as sphingolipids, sterols and proteins participate to membrane fluidity and forme lipid rafts microdomains. Few data are available on the links between lipids rafts and oxysterols. The purpose of this review is to suggest the potential role of lipid rafts microdomains in the developm…

Corrigendum to “Clinical and genetic update of corneal dystrophies” [YEXER 186C (2019) 107715]

2020

P2.10 Summation of afferent input affects sympathetic homeostasis: Mild skin tactile stimulation during painful isometric muscle contraction reduces …

2009

Marklose nervenfasern im Senium und im Sp�tstadium der Thalidomid-Polyneuropathie: quantitativ-elektronenmikroskopische Untersuchungen

1977

Sural nerve biopsies of four patients, aged 54–76 years, with a predominantly sensory type of neuropathy following high dosages of thalidomide were examined by light and electron microscopy. The present study includes a qualitative and quantitative evaluation of unmyelinated nerve fibers. Despite severe neuropathy, increased numbers of small unmyelinated axons per endoncurial area were noted in all patients. This numerical increase appeared to be independent of aging, since it was not seen in two senile controls, studied at the age of 83 and 88 years. The increase in the endoneurial density of unmyelinated axons, especially of small sized fibers, is likely to be related to regeneration foll…

Automatic Temporal Expectancy: A High-Density Event-Related Potential Study

2013

How we compute time is not fully understood. Questions include whether an automatic brain mechanism is engaged in temporally regular environmental structure in order to anticipate events, and whether this can be dissociated from task-related processes, including response preparation, selection and execution. To investigate these issues, a passive temporal oddball task requiring neither time-based motor response nor explicit decision was specifically designed and delivered to participants during high-density, event-related potentials recording. Participants were presented with pairs of audiovisual stimuli (S1 and S2) interspersed with an Inter-Stimulus Interval (ISI) that was manipulated acc…

Complex regional pain syndrome–up-to-date

2017

The pathophysiology of complex regional pain syndromes includes inflammation and central reorganisation. The treatment should be adjusted to the prevailing pathophysiology including possible psychosocial factors.