Search results for "Sensor"

Erratum to “Neurotrophin secretion: current facts and future prospects” [Progr. Neurobiol. 69 (2003) 341–374]

2004

Erratum to “Neurotrophin secretion: current facts and future prospects” [Progr. Neurobiol. 69 (2003) 341–374] Volkmar Lessmann a,∗, Kurt Gottmann b, Marzia Malcangio c a Department of Physiology and Pathophysiology, Johannes Gutenberg-University Mainz, Duesbergweg 6, Room 03/619, Mainz 55128, Germany b Department of Cell Physiology, Ruhr-University Bochum, Bochum, Germany c Sensory Function, Centre for Neuroscience, King’s College, London, UK

NECAB2 participates in an endosomal pathway of mitochondrial stress response at striatal synapses

2021

Synaptic signaling depends on ATP generated by mitochondria. Due to extensive connectivity, the striatum is especially vulnerable to mitochondrial dysfunction and thus requires efficient mitochondrial quality control. We found that the neuronal calcium-binding protein NECAB2 ensures synaptic function in the striatum by increasing mitochondrial efficiency. NECAB2 associates with early endosomes and mitochondria at striatal synapses. Loss of NECAB2 dysregulates proteins of the endosomal ESCRT machinery and oxidative phosphorylation. Mitochondria from NECAB2-deficient mice are more abundant but less efficient. These mitochondria exhibit increased respiration and superoxide production but produ…

Prior precision modulates the minimisation of prediction error in human auditory cortex

2018

AbstractThe predictive coding model of perception proposes that successful representation of the perceptual world depends upon cancelling out the discrepancy between prediction and sensory input (i.e., prediction error). Recent studies further suggest a distinction between prediction error associated with non-predicted stimuli of different prior precision (i.e., inverse variance). However, it is not fully understood how prediction error from different precision levels is minimised in the predictive process. The current research used magnetoencephalography (MEG) to examine whether prior precision modulates the cortical dynamics of the making of perceptual inferences. We presented participant…

Chapter 24 Bihemispheric plasticity after acute hand deafferentation

2003

Publisher Summary This chapter summarizes experiments showing that deprivation of somatosensory input could also elicit organizational changes in the hemisphere contralateral to the deafferented one. The existence of interactions among homotopic sites within cortical representations in both hemispheres provides a substrate for such an effect. It has been proposed that chronic deafferentation, in association with long-term practice as in blind, deaf, or individuals with amputation results in compensatory gains in the same and in other sensory modalities. However, the long-term changes described are mild and the question whether blind or deaf people develop enhanced capacities of their remain…

Sensory preconditioning in newborn rabbits: from common to distinct odor memories.

2013

Brief Communication; International audience; This study evaluated whether olfactory preconditioning is functional in newborn rabbits and based on joined or independent memory of odorants. First, after exposure to odorants A+B, the conditioning of A led to high responsiveness to odorant B. Second, responsiveness to B persisted after amnesia of A. Third, preconditioning was also functional with two overlapping pairs of odorants (A+B and B+C) and amnesia of one odorant did not affect memory of the others. Thus, incidental pairing of odorants allows reinforcement of one odorant to implicitly reinforce the others, the bond then vanishes, and the memory of each element becomes independent.

Corrigendum: Both attention and prediction are necessary for adaptive neuronal tuning in sensory processing

2017

Migraine as a Cortical Brain Disorder

2020

Purpose Migraine is an exclusively human chronic disorder with ictal manifestations characterized by a multifaceted clinical complexity pointing to a cerebral cortical involvement. The present review is aimed to cover the clinical, neuroimaging, and neurophysiological literature on the role of the cerebral cortex in migraine pathophysiology. Overview Converging clinical scenarios, advanced neuroimaging data, and experimental neurophysiological findings, indicate that fluctuating excitability, plasticity, and metabolism of cortical neurons represent the pathophysiological substrate of the migraine cycle. Abnormal cortical responsivity and sensory processing coupled to a mismatch between the …

Sensory Processing in Children with Autism Spectrum Disorder and/or Attention Deficit Hyperactivity Disorder in the Home and Classroom Contexts.

2017

Children with neurodevelopmental disorders often show impairments in sensory processing (SP) and higher functions. The main objective of this study was to compare SP, praxis and social participation (SOC) in four groups of children: ASD Group (n = 21), ADHD Group (n = 21), ASD+ADHD Group (n = 21), and Comparison Group (n = 27). Participants were the parents and teachers of these children who were 5-8 years old (M = 6.32). They completed the Sensory Processing Measure (SPM) to evaluate the sensory profile, praxis and SOC of the children in both the home and classroom contexts. In the home context, the most affected was the ASD+ADHD group. The ADHD group obtained higher scores than the ASD gr…

Testing cognition and rehabilitation in unilateral neglect with wedge prism adaptation: multiple interplays between sensorimotor adaptation and spati…

2014

Spatial neglect is a neurological condition characterised by deficits for perceiving, attending, representing, and/or performing actions within their left-sided space, responsible for numerous debilitating effects in everyday life, for poor functional recovery, and for decreased ability to benefit from treatment. Exposure to a right lateral displacement of the visual field (induced by a simple target-pointing task with base-left wedge prisms) is known to directionally bias visuomotor coordination and can be compensated by both sensorimotor adaptation and cognitive processes. Sensorimotor adaptation gives rise to after-effects whose duration is amplified in neglect patients and has been repe…

Neurobiological foundations of multisensory processing integration in people with autism spectrum disorders: The role of the medial prefrontal cortex

2014

This review aims to relate the sensory processing problems in people with Autism spectrum disorders (ASD), especially Multisensory interaction (MSI), to the role of the medial prefrontal cortex (mPFC) by exploring neuroanatomical findings; brain connectivity and Default Network (DN); global or locally directed attention; and temporal multisensory binding. The mPFC is part of the brain’s DN, which is deactivated when attention is focused on a particular task and activated on rest when spontaneous cognition emerges. In those with ASD, it is hypoactive and the higher the social impairment the greater the atypical activity. With an immature DN, cross-modal integration is impaired, resulting in …