Search results for "Sensor"
showing 10 items of 4594 documents
Concept of dynamic DNA network dedicated to DNA-Protein interactions studies
2007
The approach lies on the development of an original DNA biosensor. This self-assembled DNA biochip is constituted of a tethered lipid membrane presenting « protein/DNA » complexes. This unique assembly, using a highly flexible bifunctional molecular spacer and a fluidic matrix, allows the control of oligonucleotides surface density and their mobility thus favouring hybridization of the DNA probes in liquid environment and under weak constraints. Recent Surface Plasmon Resonance experiments lead to building of protein/DNA dimers presenting two special DNA sequences recognized by regulation proteins. We demonstrated the capacity and relevance of this biosensor in the case of an estrogen recep…
Chapter 16 - Carbon Nanotubes: Synthesis, Characterization, and Applications in Drug-Delivery Systems
2019
International audience; Nanoparticles are increasingly being considered in the medical field as an effective means to deliver drugs of interest or as diagnostic biosensors. Carbon nanotubes (CNTs) are an allotropic form of carbon related to the fullerene family. Their exceptional thermal, mechanical, and electronical properties together with their tubular shape, offering a high surface area and enabling adsorption or conjugation of a wide variety of therapeutic drugs or diagnostic agents, make CNTs attractive platforms for the treatment of various diseases. This chapter reviews the emerging synthesis, characterization, and and discusses the perspectives and obstacles of these promising nano…
The risk of obesity is associated with fat and sweet liking
2015
Introduction: Fat, added sugar and sodium are important nutritional factors involved in the risk of obesity, although these components contribute to eating pleasure thanks to their sensory properties. Few cross-sectional studies have shown equivocal results about relationships between liking and weight status. The only one prospective study has shown an increase of weight in individuals who liked sweet taste and no significant relationships for fat liking. However, the tool that assesses liking is unreliable. Objectives: The aim of the study was to investigate the prospective association between liking for fat, sweet and salt and the onset of obesity in adults. Method / Design: Liking score…
Trends in eye care use in adults treated for diabetes between 2008 and 2017 in France: a nationwide study
2019
Cholesterol metabolism via cyp46a1 in glaucoma
2012
Cholesterol metabolism via cyp46a1 in glaucoma. International society for eye research (ISER) annual meeting
Characterization of cholesterol metabolism in an experimental model of glaucoma in rats
2019
International audience; Glaucoma is a neurodegenerative pathology characterized by retinal ganglion cell death. Cholesterol homeostasis disruption has been implicated in several neurodegenerative diseases such as Alzheimer and Huntington. However, its specific role in the retina and association with glaucoma remain unclear. The aim of this study was to characterize the modifications of cholesterol metabolism occurring during an experimental model of glaucoma in rats. Eight-weeks old male rats were subjected to laser photocoagulation of episcleral veins, limbus and trabecular meshwork to elevate intraocular pressure. At a short (3 days) and a long (2 months) time period post-laser, the retin…