Search results for "Sensory Systems"
showing 10 items of 793 documents
Retinal neurodegenerative changes in the adult insulin receptor substrate-2 deficient mouse.
2014
Abstract Insulin receptor substrate-2 (Irs2) mediates peripheral insulin action and is essential for retinal health. Previous investigations have reported severe photoreceptor degeneration and abnormal visual function in Irs2-deficient mice. However, molecular changes in the Irs2 − / − mouse retina have not been described. In this study, we examined retinal degenerative changes in neuronal and glial cells of adult (9- and 12-week old) Irs2 − / − mice by immunohistochemistry. 9-week old Irs2 − / − mice showed significant thinning of outer retinal layers, concomitant to Muller and microglial cell activation. Photoreceptor cells displayed different signs of degeneration, such as outer/inner…
SANS (USH1G) expression in developing and mature mammalian retina
2008
AbstractThe human Usher syndrome (USH) is the most common form of combined deaf-blindness. Usher type I (USH1), the most severe form, is characterized by profound congenital deafness, constant vestibular dysfunction and prepubertal-onset of retinitis pigmentosa. Five corresponding genes of the six USH1 genes have been cloned so far. The USH1G gene encodes the SANS (scaffold protein containing ankyrin repeats and SAM domain) protein which consists of protein motifs known to mediate protein–protein interactions. Recent studies indicated SANS function as a scaffold protein in the protein interactome related to USH.Here, we generated specific antibodies for SANS protein expression analyses. Our…
Phosphodiesterase inhibition induces retinal degeneration, oxidative stress and inflammation in cone-enriched cultures of porcine retina.
2013
nherited retinal degenerations affecting both rod and cone photoreceptors constitute one of the causes 74 of incurable blindness in the developed world. Cyclic guanosine monophosphate (cGMP) is crucial in the 75 phototransduction and, mutations in genes related to its metabolism are responsible for different retinal 76 dystrophies. cGMP-degrading phosphodiesterase 6 (PDE6) mutations cause around 4e5% of the retinitis 77 pigmentosa, a rare form of retinal degeneration. The aim of this study was to evaluate whether phar- 78 macological PDE6 inhibition induced retinal degeneration in cone-enriched cultures of porcine retina 79 similar to that found in murine models. PDE6 inhibition was induced…
PB3. Pharyngeal Electrical Stimulation in neurointensive care patients suffering from severe post-stroke dysphagia – Post stimulation increase of sal…
2018
Introduction Dysphagia is one of the most important and prognostically relevant complications of acute stroke. Pharyngeal Electrical Stimulation (PES) is a treatment device that enhances cortical reorganization for the restoration of swallowing function after cerebral injury. Furthermore, it was shown that PES leads to a temporary increase of Substance P (SP) level in saliva but not serum in healthy adults. The neuropeptide SP likely acts as a neurotransmitter in the pharyngeal mucosa and enhances the swallow and cough reflex. Post-stroke dysphagia may be related to reduced SP-levels. Here, we investigated the association of PES treatment in neurointensive care patients suffering from sever…
Molecular basis of human Usher syndrome: deciphering the meshes of the Usher protein network provides insights into the pathomechanisms of the Usher …
2006
Usher syndrome (USH) is the most frequent cause of combined deaf-blindness in man. It is clinically and genetically heterogeneous and at least 12 chromosomal loci are assigned to three clinical USH types, namely USH1A-G, USH2A-C, USH3A (Davenport, S.L.H., Omenn, G.S., 1977. The heterogeneity of Usher syndrome. Vth Int. Conf. Birth Defects, Montreal; Petit, C., 2001. Usher syndrome: from genetics to pathogenesis. Annu. Rev. Genomics Hum. Genet. 2, 271-297). Mutations in USH type 1 genes cause the most severe form of USH. In USH1 patients, congenital deafness is combined with a pre-pubertal onset of retinitis pigmentosa (RP) and severe vestibular dysfunctions. Those with USH2 have moderate to…
A Psychometric Evaluation of the Group Environment Questionnaire in a Sample of Professional Basketball and Soccer Players
2013
Psychometric properties of the Group environment Questionnaire were investigated in a large sample of soccer (n = 222) and professional basketball players (n = 375). Confirmatory factor analysis was performed both on the total sample and on the two sub samples through a multi-group approach; associations between cohesion and the duration of belonging to the team were also explored. Results confirmed the four-factor structure proposed by Carron's original model even though some items with low loadings were eliminated. No signifcant associations were found between team cohesion and the duration of belonging to the team. © Perceptual & Motor Skills 2013.
Sight sublimated by odors: effect of subliminal odors on facial emotion detection.
2014
Perception of illusory surfaces and contours in goldfish
2007
Goldfish(Carassius auratus)were trained to discriminate triangles and squares using a two choice procedure. In the first experiment, three goldfish were trained with food reward on a black outline triangle on a white background, while a black outline square was shown for comparison. In transfer tests, a Kanizsa triangle and a Kanizsa square were presented, perceived by humans as an illusory triangle- or square-shaped surface of slightly higher brightness than the background. The choice behavior in this situation indicates that goldfish are able to discriminate between both figures in almost the same way as in the training situation. In control experiments goldfish did not discriminate betwe…
Do Individual Reactions Predict Group Reactions?
1987
Summary.-Group reactions of three-man groups included in 71 junior ice hockey players were measured using a homeostat. Individual reaction times (simple reaction time, choice reaction time) did not predict group performance. In social psychology many studies have compared the effectiveness of an individual and a group (Kelley & Thibaut. 1969). Less research has been done to predict group performance by individuals' performance. In this study group performance was measured by a homeostat developed in the USSR (Medvedev, 1967). Ic consists of three microammeters connected in the same electric network. When the Examiner rotates the electric resistance, the subjects ought to restore the equilib…
Space information is important for reading
2009
AbstractReading a text without spaces in an alphabetic language causes disruption at the levels of word identification and eye movement control. In the present experiment, we examined how word discriminability affects the pattern of eye movements when reading unspaced text in an alphabetic language. More specifically, we designed an experiment in which participants read three types of sentences: normally written sentences, regular unspaced sentences, and alternatingbold unspaced sentences. Although there was a reading cost in the unspaced sentences relative to the normally written sentences, this cost was much smaller in alternatingbold unspaced sentences than in regular unspaced sentences.