Search results for "Series"
showing 10 items of 1193 documents
A Dirichlet Autoregressive Model for the Analysis of Microbiota Time-Series Data
2021
Growing interest in understanding microbiota dynamics has motivated the development of different strategies to model microbiota time series data. However, all of them must tackle the fact that the available data are high-dimensional, posing strong statistical and computational challenges. In order to address this challenge, we propose a Dirichlet autoregressive model with time-varying parameters, which can be directly adapted to explain the effect of groups of taxa, thus reducing the number of parameters estimated by maximum likelihood. A strategy has been implemented which speeds up this estimation. The usefulness of the proposed model is illustrated by application to a case study.
Neuroendocrine differentiation in a large series of genetically-confirmed Ewing’s sarcoma family tumor: Does it provide any diagnostic or prognostic …
2021
Given the potential for neuroendocrine differentiation in Ewing's sarcoma family of tumors (ESFT), we aimed to determine neuroendocrine expression in a large series of genetically-confirmed ESFT and its prognostic significance in clinically-localised neoplasms (n = 176). Slides prepared from tissue microarrays were stained for Insulinoma-associated protein 1 (INSM1), CD56, chromogranin-A and synaptophysin. INSM1 expression was present in 59% of ESFT, while synaptophysin, chromogranin-A and CD56 were expressed in only 13%, 8% and 5% of ESFT, respectively. Histological subtypes were only significantly correlated with INSM1 (p = 0.032) or CD56 (p = 0.016) immunoexpression. Regarding prognosis,…
Identification and visualization of differential isoform expression in RNA-seq time series
2018
Abstract Motivation As sequencing technologies improve their capacity to detect distinct transcripts of the same gene and to address complex experimental designs such as longitudinal studies, there is a need to develop statistical methods for the analysis of isoform expression changes in time series data. Results Iso-maSigPro is a new functionality of the R package maSigPro for transcriptomics time series data analysis. Iso-maSigPro identifies genes with a differential isoform usage across time. The package also includes new clustering and visualization functions that allow grouping of genes with similar expression patterns at the isoform level, as well as those genes with a shift in major …
Robust Analysis of Time Series in Virome Metagenomics
2018
Metagenomics is a powerful tool for assessing the functional and taxonomic contents in biological samples as it makes feasible to study, simultaneously, the whole living community related to a host organism or medium: all the microbes, including virus, bacteria, archaea, fungi, and protists. New DNA and RNA sequencing technologies are dramatically decreasing the cost per sequenced base, so metagenomic sequencing is becoming more and more widespread in biomedical and environmental research. This is opening the possibility of complete longitudinal metagenomic studies, which could unravel the dynamics of microbial communities including intra-microbiome and host-microbiome interactions through …
A comprehensive approach to assigning periodontal prognosis
2018
Abstract Aim The purpose of this retrospective case series study was to evaluate the usefulness and performance of a comprehensive approach to assigning periodontal prognosis by assessing the risk of tooth loss due to periodontal disease (TLPD) and estimate the survival time (ST) of periodontally compromised teeth (PCT). Material and Methods The Long‐Term Outcome (LTO) index was utilized to assess the risk of TLPD, at baseline, in 100 patients following periodontal maintenance for a mean 24.7 year (±2.4). A TLPD prediction model was utilized to assign ST to PCT. The performance of the TLPD prediction based on both parameters was assessed. Results The mean TLPD rate increased as the LTO inde…
Ficciones inmunitarias. Sobre la lógica de la inmunidad en la cultura contemporánea
2018
This article develops the concept of “immunitarian fiction” taking as paradigmatic examples epidemics and zombie narratives, which share the idea of contagion as the main matrix of their narrative. The article tries to address the following question: in what way do these fictions, and other similar ones, participate in the imaginary of immunity and, at the same time, show some of their internal contradictions? For this, the text reflects on a set of cultural products of mass diffusion (novels, television series, cinematographic works). We analyze, in the first place, how these fictions highlight the fears and social anxieties linked to the tensions of the “immune paradigm” and represent the…
System Dynamics in the Predictive Analytics of Container Freight Rates
2021
This study proposes a two-tier cross-validation and backtesting procedure, including expanding and rolling-window test metrics in predictive analytics of container freight rates by utilizing the system dynamics approach. The study utilized system dynamics to represent the nonlinear complex structure of container freight rates for predictive analytics and performed univariate and multivariate time-series analysis as benchmarks of the conventional approach. In particular, the China containerized freight index (CCFI) has been investigated through various parametric methodologies (both conventional time-series and system dynamics approaches). This study follows a strict validation process cons…
Victim-Naming in the Murder Mystery Series Twin Peaks: A Corpus-Stylistic Study
2020
Corpus linguistics is advancing rapidly in the study of a wide variety of genres, but is still at its infancy in the study of TV series, a genre daily consumed by millions of viewers. Murder mystery series are one of the most popular and proliferous, but no studies, to date, have used corpus-stylistics methodologies in the analysis of the pivotal character of the victim in the whole narrative. This paper applied this methodology hoping to shed some light on the quantitative and qualitative relationship between the participation roles of the characters, and the frequency and distribution of victim-naming choices in the dialogue of the two first seasons of the acclaimed TV series Twin Peaks. …
“Apparently, women don't know how to operate doors": A corpus-based analysis of women stereotypes in the TV series <i>3rd Rock from the Sun<…
2017
This paper explores how women stereotypes are discursively evaluated in the TV sitcom 3rd Rock from the Sun by paying attention to the societal, cultural and ideological values they convey. Following recent trends for the study of television series (Bednarek, 2010), the analysis is both qualitative and quantitative, adopting a Corpus-Assisted Discourse Analysis approach (Baker, 2006; Partington, 2004). The contextualised analysis of words that refer to women confirms that the sitcom writers of 3rd Rock from the Sun purposefully resort to stereotyping as a verbal strategy to create humour while conveying negative attitudes towards women.
The synthesis of fluorinated heteroaromatic compounds. Part 1. Five-membered rings with more than two heteroatoms. A review
2005
(2005). THE SYNTHESIS OF FLUORINATED HETEROAROMATIC COMPOUNDS. PART 1. FIVE-MEMBERED RINGS WITH MORE THAN TWO HETEROATOMS. A REVIEW. Organic Preparations and Procedures International: Vol. 37, No. 5, pp. 447-506.