Search results for "Serp"
showing 10 items of 205 documents
Sequencing, De Novo Assembly and Annotation of the Colorado Potato Beetle, Leptinotarsa decemlineata, Transcriptome
2012
Background. The Colorado potato beetle (Leptinotarsa decemlineata) is a major pest and a serious threat to potato cultivation throughout the northern hemisphere. Despite its high importance for invasion biology, phenology and pest management, little is known about L. decemlineata from a genomic perspective. We subjected European L. decemlineata adult and larval transcriptome samples to 454-FLX massively-parallel DNA sequencing to characterize a basal set of genes from this species. We created a combined assembly of the adult and larval datasets including the publicly available midgut larval Roche 454 reads and provided basic annotation. We were particularly interested in diapause-specific g…
Modeling caspase-1 inhibition: Implications for catalytic mechanism and drug design.
2019
Abstract The metabolic product of caspase-1, IL-1β, is an important mediator in inflammation and pyroptosis cell death process. Alzheimer's disease, septic shock and rheumatoid arthritis are IL-1β mediated diseases, making the caspase-1 an interesting target of pharmacological value. Many inhibitors have been developed until now, most of them are peptidomimetic with improved potency. In the present study, all-atom molecular dynamics simulations and the MM/GBSA method were employed to reproduce and interpret the results obtained by in vitro experiments for a series of inhibitors. The analysis shows that the tautomeric state of the catalytic His237 impact significantly the performance of the …
ER+-derived breast cancer stem cells reveal a high expression of the serpin protease inhibitor PI-9.
2015
Introduction: Breast cancers (BC) are the major cause of death in women. More than 70% of BCs express high levels of estrogen receptor-α (ERα) and are sustained for their growth by the hormone. Estrogens seem to protect BC cells from apoptosis mediated by immunosurveillance associated with cytotoxic T lymphocytes and NK cells granzyme B release. However, the production of granzyme B inhibitor PI-9 by tumor cells causes a short-circuit in immunosurveillance’s signalling. Although it has been shown the role of PI-9 in BC cells, its presence has not been investigated in tumor stem cells so far. Methods: Cell viability was evaluated by MTT, cell cycle by propidium iodide staining; mRNA and prot…
Monstrous Hybrids in Shakespeare’s King Lear
2017
ABSTRACT: This article seeks to present the different languages (emblems, Renaissance translations of classical myths, biblical exegesis) that inform the images of monsters which, as hybrid creatures blending human and animal characteristics, serve a dramatic function in Shakespeare’s King Lear . It means to question the ways in which the play links filial ingratitude with female monstrosity and Lear’s madness. Tracing the classical and medieval lineage of the monstrous bestiary (serpent, tiger, vulture) in King Lear and connecting it to emblematic readings of Shakespeare’s time, it explores how Shakespeare provides a dynamic characterisation of Goneril and Regan through their bestialisatio…
Mauceri: Messina nel Settecento, o l'alchimia della memoria
2009
Il contributo affronta uno dei testi meno conosciuti di Enrico Mauceri, Messina nel Settecento, rilevandone le tangenze con la coeva cultura erudita
A highly dynamic hot hydrothermal system in the subduction environment: Geochemistry and geochronology of jadeitite and associated rocks of the Sierr…
2021
A U-Pb zircon date of ~113 Ma revealed that a variety of jadeitites and related omphacitite, chloritite and albite-rich rocks from the subduction-related Sierra del Convento block-in-serpentinite-matrix mélange (eastern Cuba) formed nearly synchronously with MORB metabasite-derived anatectic trondhjemitic liquids at high-temperature and pressure in a hot subduction environment. Field, petrologic and geochemical data indicate hydrothermal/metasomatic processes triggered by juvenile fluids likely evolved from the crystallizing hydrous trondhjemitic melts. These fluids, variably mixed with sediment-derived fluids and channelized along fractures in the supra-slab mantle, precipitated relatively…
Water chemistry and abiogenic methane content of a hyperalkaline spring related to serpentinization in the Argolida ophiolite (Ermioni, Greece)
2018
Abstract Hyperalkaline mineral springs related to active continental serpentinization are a theme of growing interest since they may contain significant amounts of abiotic gas and have important implications for energy resource exploration, subsurface microbiology and astrobiology. We report the discovery of a new hyperalkaline (pH∼12) spring issuing in the Agioi Anargyroi monastery at Ermioni (Greece), connected to serpentinization of peridotites of the Argolis ophiolite. Two water samples have been collected from separated springs and analysed for the chemical composition of major, minor and trace elements, and isotopic composition (2H and 18O) of water by IC, ICP-OES, ICP-MS and IRMS, an…
The origin of the serpentine endemic Minuartia laricifolia subsp. ophiolitica by vicariance and competitive exclusion.
2013
Serpentine soils harbour a unique flora that is rich in endemics. We examined the evolution of serpentine endemism in Minuartia laricifolia, which has two ecologically distinct subspecies with disjunct distributions: subsp. laricifolia on siliceous rocks in the western Alps and eastern Pyrenees and subsp. ophiolitica on serpentine in the northern Apennines. We analysed AFLPs and chloroplast sequences from 30 populations to examine their relationships and how their current distributions and ecologies were influenced by Quaternary climatic changes. Minuartia laricifolia was divided into four groups with a BAPS cluster analysis of the AFLP data, one group consisted only of subsp. ophiolitica, …
Giacomo Serpotta e Giacomo Amato: una problematica collaborazione
2017
Il contributo riesamina, alla luce di un'attenta rilettura dei dati documentari, il rapporto professionale esistente tra l'architetto Giacomo Amato e lo stuccatore Giacomo Serpotta nella Palermo tra Sei Settecento. I documenti sono rivelatori di prassi in atto e in definitiva i ruoli e le competenze delle due personalità artistiche appaiono differenti e disegnano rapporti di collaborazione mai paritaria. La realtà che sembra trasparire è che l'architetto e lo stuccatore possedessero un'interpretazione molto diversa del progetto e del proprio mestiere.
E il Barocco restò di stucco
2023
Proveniente da una famiglia palermitana di scultori, Giacomo Serpotta si è distinto per le sue particolari abilità di stuccatore e per la sua capacità di coniugare scultura e architettura in ardite scenografie barocche. esempio insigne è l’oratorio del Santissimo Rosario in Santa Cita a Palermo.