Search results for "Shape"

Side-specific effects by cadmium exposure: Apical and basolateral treatment in a coculture model of the blood–air barrier

2010

Cadmium (Cd{sup 2+}) is a widespread environmental pollutant, which is associated with a wide variety of cytotoxic and metabolic effects. Recent studies showed that intoxication with the heavy metal most importantly targets the integrity of the epithelial barrier. In our study, the lung epithelial cell line, NCI H441, was cultured with the endothelial cell line, ISO-HAS-1, as a bilayer on a 24-well HTS-Transwell (registered) filter plate. This coculture model was exposed to various concentrations of CdCl{sub 2}. The transepithelial electrical resistance decreased on the apical side only after treatment with high Cd{sup 2+} concentrations after 48 h. By contrast, a breakdown of TER to less t…

[The effect of instrumentation on original apical foramen shape using steel vs niti rotatory: computerized analysis]

2002

BACKGROUND. A fundamental requirement to obtain a correct endodontic preparation depends on the respect, during cleaning and shaping, of the original morphology of the apical foramen, (AF), so that the filling material will form a complete seal. METHODS. In our previous studies, in order to verify if this presumption was respected using rotary NiTi instruments with cutting tip, we instrumented extracted teeth characterised by a different degree of root curvatures. Using a standardized system to replace the sample, the original shape of the apical foramen of each tooth was recorded using a computerised technique and then compared to the shape after instrumentation. The data showed difference…

Precision electroweak measurements on the Z resonance

2005

We report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. The data consist of 17 million Z decays accumulated by the ALEPH, DELPHI, L3 and OPAL experiments at LEP, and 600 thousand Z decays by the SLD experiment using a polarised beam at SLC. The measurements include cross-sections, forward-backward asymmetries and polarised asymmetries. The mass and width of the Z boson, $\MZ$ and $\GZ$, and its couplings to fermions, for example the $\rho$ parameter and the effective electroweak mixing angle, are precisely measured. The number of light neutrino species is determined to be 2.9840…

A genetic algorithm for combined topology and shape optimisations

2003

A method to find optimal topology and shape of structures is presented. With the first the optimal distribution of an assigned mass is found using an approach based on homogenisation theory, that seeks in which elements of a meshed domain it is present mass; with the second the discontinuous boundaries are smoothed. The problem of the optimal topology search has an ON/OFF nature and has suggested the employment of genetic algorithms. Thus in this paper a genetic algorithm has been developed, which uses as design variables, in the topology optimisation, the relative densities (with respect to effective material density) 0 or 1 of each element of the structure and, in the shape one, the coord…

THE TOPOLOGY OPTIMIZATION IN THE PRODUCT DESIGN PROCESS

2009

The design process represents, already for a long time now, a very interesting research field for the scientific community that has tried, through its own activity of research and development, to make it faster, more reliable and efficient. Thanks to this continuous development, during the last years, the product design process has suffered a remarkable improvement, both regarding the methodological aspect, become mostly structured, objective and rational, and as regards the helping tools for the design like, for example, the software CAD, FEM, CFD, that have been improved in their efficiency and functionality. In this context, the development of more and more reliable and simple to use met…

Classrooms, Salons, Academies, and Courts: Mateu Orfila (1787–1853) and Nineteenth-Century French Toxicology

2014

AbstractThis paper analyses the connections between nineteenth-century courtrooms, academies, and laboratories by focusing on the life and works of Mateu Orfila (1787–1853), one of the most famous nineteenth-century toxicologists. At the apex of his career, Orfila moved regularly between his laboratory and his chair at the Paris Faculty of Medicine to meetings of the Academy of Medicine, and the courtrooms in which he was frequently called upon as an expert witness in murder trials. Tracing Orfila's biographical path, this paper deals with four main sites of nineteenth-century toxicology: classrooms, salons, academies, and courtrooms. These sites are understood as both tangible places, whos…

Resveratrol initiates differentiation of mouse skeletal muscle-derived C2C12 myoblasts.

2012

Resveratrol is one of the most widely studied bio-active plant polyphenols. While its effect on endothelial blood vessel cells, cancer cells, inflammatory processes and neurodegenerative events is well documented, little is known about the implication of this phytophenol in differentiating processes, particularly in skeletal muscle cells. Here, we report the effects of resveratrol on mouse skeletal muscle-derived cells (C2C12) in either a nondifferentiated (myoblasts) or differentiated state (myotubes) by evaluating resveratrol uptake, cell proliferation, changes in cell shape, and the expression of genes encoding muscle-specific transcription factors or contractile proteins. Resveratrol: (…

New Characterization Methodology For Shape Memory Alloys

2011

Aportaciones documentales sobre cruces de orfebrería valencianas. Siglos XIV y XV

2020

The article intends to make a contribution of new documentary references, from the notarial funds of the Valencian archives, in which news about parish crosses and Lignum Crucis from the silversmith center of Valencia during the fourteenth and fifteenth centuries are collected. The importance of these typologies lies in being the main elements of Christian worship, so it was an essential piece in each parish that allowed the provision in them of models of varied typology and functionality; for that reason they are conserved from altar crosses, cross-shaped reliquaries ?known as Lignum Crucis or Veracruz ?to processional crosses, larger and representative of the parish community to which it …

Percepción actual de la estética de la sonrisa

2020

Introducción: La belleza de una sonrisa constituye un sentimiento altamente subjetivo, y por ello los ideales de una sonrisa bonita pueden ser extensamente distintos y variables en la población. El objetivo de este estudio fue determinar los parámetros ideales de algunos componentes de la sonrisa, e igualmente conocer si la percepción estética de los mismos varía según profesionales de la odontología y público general, así como entre diestros y zurdos. Los aspectos de la sonrisa estudiados fueron: escalón vertical entre incisivos central y lateral, exposición gingival, forma de los dientes y desviación de línea media dental tanto hacia el lado derecho como izquierdo. Material y método: La m…