Search results for "Ship"
showing 10 items of 6731 documents
Exploring the application of blockchain to humanitarian supply chains: insights from Humanitarian Supply Blockchain pilot project
2021
PurposeSome studies and reports have recently suggested using blockchain technology to improve transparency and trust in humanitarian supply chains (HSCs). However, evidence-based studies to display the utility and applicability of blockchains in HSCs are missing in the literature. This paper aims to investigate the key drivers and barriers of blockchain application to HSCs and explore whether evidence could support that the application of blockchain improves transparency and trust in HSCs.Design/methodology/approachThis paper puts forward a two-stage approach to explore the blockchain application in HSCs: an initial exploration of humanitarian practitioners and academicians interested in b…
The Integration of the Supply Chain as a Dynamic Capability for Sustainability: The Case of an Innovative Organic Company
2018
Numerous research projects have demonstrated that a firm’s ability to integrate, build, and reconfigure internal and external competencies to adapt to changes in its environment is a key capability for its competitiveness. However, in the case of developing the capabilities needed to implement innovation, we have found that the ability to integrate knowledge into the supply chain is also crucial since it is an essential requirement for bringing in technological change and product innovation. The purpose of this chapter is to understand the role of supplier integration in the implementation of radical innovation. First, we propose a theoretical model to connect supplier integration as a dyna…
From Neo-Functional Peace to a Logic of Spillover in EU External Policy: A Response to Visoka and Doyle
2017
In their recently published JCMS article, Gezim Visoka and John Doyle have proposed the concept of ‘neofunctional peace’ as a means to conceptualize the EU's peacemaking practices in the case of the EU-facilitated Belgrade-Pristina dialogue. This article challenges the ‘neo-functional peace’ on conceptual and empirical grounds. We critically discuss Visoka and Doyle's (2016) reading of neofunctionalism and question parts of their empirical evidence given for the existence of a ‘neo-functional peace’. Going beyond a mere critique of the article by Visoka and Doyle and arguing that the authors may not have fully exploited neofunctionalism's potential for theorizing EU external policy, we stip…
The politics of Argentina today: human rights and Kirchnerismo
2016
After the effects of bloody dictatorship that whipped the region, Argentina as many other Latin American countries experienced a great trauma which not only altered the ways politics was lived, but also undermined the social trust of citizens respecting to their institutions. The rise of Kirchneristes and Kirchnerismo post stock and market crisis of 2001, initiated a new age in Argentina. Kirchnerismo opened the doors for the vindication of many claims of human rights organisations, but at the same time, the discourse of human rights was adjusted to the interests of Cristina Kirchner and her followers. As a result of this, the cause of human rights allowed government to produce a new way of…
The Recent Development of a Sweet-Tasting Brazzein and its Potential Industrial Applications
2016
International audience; Brazzein is a small heat- and pH-stable sweet-tasting protein isolated from the West African plant, Pentadiplandra brazzeana. Brazzein combines a highly sweet potency, a long history of human consumption, and a remarkable stability, giving it great potential as a natural sweetener. Due to the difficulties of obtaining brazzein from its natural source, several efforts have been made to express brazzein using various heterologous expression systems. This chapter describes the biochemical, structural, sensory, and physiological properties of brazzein. We will summarize the current knowledge of the structure-activity relationship of brazzein. The biotechnological product…
QSPR Prediction of Retention Times of Methylxanthines and Cotinine by Bioplastic Evolution
2018
High-performance liquid-chromatographic retention times of methylxanthines and cotinine in human plasma and urine are modelled by structure–property relationships. Bioplastic evolution is an evolutionary perspective conjugating the effect of acquired characters, and relations that emerge among the principles of evolutionary indeterminacy, morphological determination and natural selection. It is applied to design co-ordination index, which is used to characterize retentions of methylxanthines, etc. Parameters used to calculate co-ordination index are formation enthalpy, molecular weight and surface area. Morphological and co-ordination indices provide strong correlations. Effect of different…
Investigation of Isoindolo[2,1-a] quinoxaline-6-imines as Topoisomerase I Inhibitors with Molecular Modeling Methods
2017
Background: Isoindolo[2,1-alpha] quinoxalines constitute an important class of compounds which demonstrated potent antiproliferative activity against different human tumor cell lines and topoisomerase I inhibitors. In particular, their water soluble imine or iminium salts recently synthesized showed potent growth inhibitory effect on NCI-60 tumor cell line panel and biological studies performed on the most active compounds demonstrated that they cause DNA damage via topoisomerase I poisoning. Objective: Herein, we investigate with molecular modeling methods, the common features responsible for topoisomerase I inhibition of the water-soluble isoindolo[2,1-alpha] quinoxalin-6-imines, by compa…
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
2017
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, …
2,3-Dihydrobenzofuran privileged structures as new bioinspired lead compounds for the design of mPGES-1 inhibitors
2016
International audience; 2,3-Dihydrobenzofurans are proposed as privileged structures and used as chemical platform to design small compound libraries. By combining molecular docking calculations and experimental verification of biochemical interference, we selected some potential inhibitors of microsomal prostaglandin E2 synthase (mPGES)-1. Starting from low affinity natural product 1, by our combined approach we identified the compounds 19 and 20 with biological activity in the low micromolar range. Our data suggest that the 2,3-dihydrobenzofuran derivatives might be suitable bioinspired lead compounds for development of new generation mPGES-1 inhibitors with increased affinity.
Therapeutic drug monitoring as a tool to optimize 5-FU-based chemotherapy in gastrointestinal cancer patients older than 75 years.
2019
Abstract Aims Most clinical trials exclude elderly people, leading to a limited understanding of the benefit-to-risk ratio in this population. Despite existing data regarding the oncological management of elderly receiving fluorouracil (5-FU)-based regimen, our objective was to investigate 5-FU exposure/toxicity relationship in patients ≥75 years and compare the effectiveness of 5-FU therapeutic drug monitoring between elderly and younger patients. Methods Hundred fifty-four patients (31 of whom are older than 75 years) with gastrointestinal cancers, who were to receive 5-FU–based regimens, were included in our study. At cycle 1 (C1), the 5-FU dose was calculated using patient's body surfac…