Search results for "Signal"
showing 10 items of 6924 documents
Protein SRP54 iz morske spužve Geodia cydonium
2002
In the systematic search for phylogenetically conserved proteins in the simplest and most ancient extant metazoan phylum – Porifera, we have identified and analyzed a cDNA encoding the signal recognition particle 54 kD protein (SRP54) from the marine sponge Geodia cydonium (Demospongiae). The signal recognition particle (SRP) is a universally conserved ribonucleoprotein complex of a very ancient origin, comprising SRP RNA and several proteins (six in mammals). The nucleotide sequence of the sponge cDNA predicts a protein of 499 amino acid residues with a calculated Mr of 55175. G. cydonium SRP54 displays unusually high overall similarity (90 %) with human/mammalian SRP54 proteins, higher th…
A novel technique for the CMRR improvement in a portable ECG system
2017
This paper presents a new technique to improve the quality of the ECG signals, increasing the Common Mode Rejection Ratio (CMRR). We developed a portable wireless Bluetooth ECG system able to acquire 12 leads, communicating with Smartphones and PCs. Many experiments have been made for measuring CMRR decay due to the difference on skin-electrodes impedances, the asymmetries of the amplifiers input stages and external components. Using some digital potentiometers, the system is able to compensate for these, increasing the CMRR of about 18 dB.
Activation of alpha-1A adrenoceptors mobilizes calcium from the intracellular stores in myocytes from rat portal vein.
1994
International audience; Intracellular free Ca++ concentration ([Ca++]i) was monitored using the fluorescence from the dye fura-2-acetoxymethylester in single myocytes from rat portal vein. In the presence of oxodipine (a L-type Ca++ channel inhibitor), norepinephrine (10 microM) evoked transient increases in [Ca++]i which were related to release of Ca++ from intracellular stores. The alpha-1 adrenoceptors mediating intracellular Ca++ release and inositol phosphate accumulation were identified by using subtype-selective agonists and antagonists. Pretreatment with chloroethylclonidine had little effect on the norepinephrine-induced increase in [Ca++]i and inositol phosphate accumulation. In c…
A48 COLITIS FAVORS THE EXPANSION OF BACTERIA THAT ACTIVATE PAR2 AMPLIFYING INFLAMMATORY RESPONSE
2020
Abstract Background Proteolytic imbalance has been described in patients with inflammatory bowel disease (IBD) and in different models of experimental colitis. Although the proteases reported to be increased are mainly from the host, the role of bacterial proteases has recently emerged, as they can promote inflammation, in part, through activation of Protease-activated receptors (PARs). PAR2 deficient mice are resistant to inflammation and PAR2 activation affects multiple aspects of the tissue response to injury. However, PAR2 communicates with other receptors such as toll-like and other PARs, which are important in multiple immune signaling pathways. Thus, the direct implication of PAR2 in…
Design and performance evaluation of a high power density EMI filter for PWM inverter-fed induction motor drives
2015
This paper presents the design of an electromagnetic interference (EMI) filter for a low voltage high current induction motor drives supplied by DC power grids, such as those used in several vehicle applications. In order to effectively design the EMI filter a suitable Common Mode/Differential Mode (CM/DM) separation technique has been used. In consideration of the high operating currents, a software based separation technique using time domain measurements has been applied. The proposed technique allows the CM and DM sections of the EMI filter to be properly selected in a more economical way, i.e. without the need of dedicated hardware or costly radio frequency (RF) instrumentation. The de…
Optimal Design of an X-Band, Fully-Coaxial, Easily-Tunable Broadband Power Equalizer for a Microwave Power Module
2020
A microwave power module (MPM), which is a hybrid combination of a solid-state power amplifier (SSPA) as a driver and a traveling-wave tube amplifier (TWT) as the final high power stage, is a high-power device largely used for radar applications. A gain equalizer is often required to flatten the TWT output power gain owing to its big gain fluctuations over the operating frequency range. In this paper, the design of an X-band, fully-coaxial, easily-tunable broadband power equalizer for an MPM is presented. The structure is composed of a coaxial waveguide as the main transmission line and a coaxial cavity loaded with absorbing material as a resonant unit. Sensitivity analyses of the attenuati…
Energy-Efficient Protocol Design
2015
Recent studies have shown that the total energy consumed by the Internet has followed an increasing trend over the years. A considerable part of this energy is wasted due to an inefficient utilization of edge devices , that is, Personal Computers (PCs) and other user equipment in homes and offices. PCs are often left on even when they are not used (e.g., overnight or during weekends), while other edge devices, such as printers, IP phones, and displays, are typically kept always on , especially in public buildings. A number of solutions have been proposed for eliminating, or reducing, energy wastes caused by edge devices. In this chapter, we propose a general taxonomy for their classificatio…
Expression of the Sonic Hedgehog Embryonic Signalling Pathway Components in Matched Pre-Treatment and Relapsed Small Cell Lung Cancer Biopsies
2021
Abstract Cancer stem cells may be responsible for tumour regrowth and acquisition of resistance in small cell lung cancer (SCLC). The Hedgehog pathway regulates survival and proliferation of tissue progenitor and stem cell populations, promoting the expression of stem cell related and proliferative genes. We evaluated the Sonic Hedgehog (Shh) embryonic signalling pathway in relapsed SCLC. Expression levels of Shh related genes GLI1, SMO, SUFU, PTCH1, HHIP, BCL2, BMI, ZEB1, ZEB2, N-MYC, Twist1 were analysed by qRT-PCR in matched pre-treatment and relapsed tumour fresh frozen biopsies of three SCLC patients. Expression of each gene was compared using the paired samples t-test, as well as comp…
Magnetic Stochastic Resonance in systems described by Dynamic Preisach Model
2008
Stochastic resonance (SR) is generally considered as an enhancement of the system response for certain finite values of the noise strength. In particular the signal to noise ratio (SNR) and the signal amplification show a maximum as a function of the noise intensity. This effect has been experimentally observed in many physical systems and also in magnetic systems. However, as far as magnetic systems are concerned, the dynamic features of the systems have been neglected and it has been assumed that the typical relaxation time is negligible. However this is clearly a rough approximation. In order to clarify this relation, in this paper we numerically study magnetic stochastic resonance in se…
Anti-Aging Physiological Roles of Aryl Hydrocarbon Receptor and Its Dietary Regulators
2021
The vast majority of the literature on the aryl hydrocarbon receptor is concerned with its functions in xenobiotic detoxification. However, in the course of evolution, this receptor had to have physiological (rather than toxicological) functions. Our aim was to review the aryl hydrocarbon receptor’s role in the physiological functions involved in aging. This study was performed by searching the MEDLINE and Google Academic databases. A total of 34 articles were selected that focused specifically on the aryl hydrocarbon receptor and aging, the aryl hydrocarbon receptor and physiological functions, and the combination of both. This receptor’s main physiological functions (mediated by the modul…