Search results for "Signal"
showing 10 items of 6924 documents
How can I signal my quality to emerge from the crowd? A study in the crowdsourcing context
2022
Crowdsourcing contests are characterized by an intensive level of competition because of the extensive number of solvers that voluntarily self-select to participate in such contests. This study aims at understanding how solvers can signal their quality attributes through the community functionalities, i.e. the online profile and the discussion blog of the crowdsourcing platform, to improve their chances of winning crowdsourcing contests. Drawing on signaling theory, we hypothesize that signaling their skills and capabilities by crafting profiles rich in personal and professional information and by participating actively within the discussion blog by posting and commenting, solvers can influ…
Molecular mechanisms of sorafenib action in liver cancer cells.
2012
Sorafenib, a multikinase inhibitor, recently received FDA approval for the treatment of advanced hepatocellular carcinoma (HCC). However, as the clinical application of sorafenib evolves, there is increasing interest in defining the mechanisms underlying its anti-tumor activity. Considering that this specific inhibitor could target unexpected molecules depending on the biologic context, a precise understanding of its mechanism of action could be critical to maximize its treatment efficacy, while minimizing adverse effects. Two human HCC cell lines (HepG2 and Huh7), carrying different biological and genetic characteristics, were used in this study to examine the intracellular events leading …
A systems biology perspective on cholangiocellular carcinoma development: focus on MAPK-signaling and the extracellular environment.
2008
Background/Aims Multiple genes have been implicated in cholangiocellular carcinoma (CCC) development. However, the overall neoplastic risk is likely associated with a much lower number of critical physiological pathways. Methods To investigate this hypothesis, we extracted all published genetic associations for the development of CCC from PubMed (genetic association studies, but also studies associating genes and CCC in general, i.e. functional studies in cell lines, genetic studies in humans, knockout mice etc.) and integrated CCC microarray data. Results We demonstrated the MAPK pathway was consistently enriched in CCC. Comparing our data to genetic associations in HCC often successfully …
Targeted therapy for hepatocellular carcinoma: novel agents on the horizon.
2012
Hepatocellular carcinoma (HCC) is the most common liver cancer, accounting for 90% of primary liver cancers. In the last decade it has become one of the most frequently occurring tumors worldwide and is also considered to be the most lethal of the cancer systems, accounting for approximately one third of all malignancies. Although the clinical diagnosis and management of early-stage HCC has improved significantly, HCC prognosis is still extremely poor. Furthermore, advanced HCC is a highly aggressive tumor with a poor or no response to common therapies. Therefore, new effective and well-tolerated therapy strategies are urgently needed. Targeted therapies have entered the field of anti-neopl…
What links BRAF to the heart function? new insights from the cardiotoxicity of BRAF inhibitors in cancer treatment
2015
The RAS-related signalling cascade has a fundamental role in cell. It activates differentiation and survival. It is particularly important one of its molecules, B-RAF. B-RAF has been a central point for research, especially in melanoma. Indeed, it lacked effective therapeutic weapons since the early years of its study. Molecules targeting B-RAF have been developed. Nowadays, two classes of molecules are approved by FDA. Multi-target molecules, such as Sorafenib and Regorafenib, and selective molecules, such as Vemurafenib and Dabrafenib. Many other molecules are still under investigation. Most of them are studied in phase 1 trials. Clinical studies correlate B-RAF inhibitors and QT prolonga…
Automatic screening of cardiac disorders using wavelet analysis of heart sound
2017
Body auscultation is a dominant method for physical examination of human heart using conventional stethoscope. This clinical method is non invasive and efficient but it requires a medical expert to interpret the heart sound for assessment of cardiac disorders. This paper presents analysis of heart sounds in wavelet domain for automated screening of cardiac disorders. Heart sound signal is transformed in wavelet domain to find out discrimination between heart sounds recorded from healthy and anomalous patients. Discriminatory features extracted from wavelet coefficients of heart sound are subjected to machine learning for screening of cardiac disorders automatically. The proposed method for …
Cumulative-Sum-Based Localization of Sound Events in Low-Cost Wireless Acoustic Sensor Networks
2014
Wireless acoustic sensor networks (WASNs) are known for their potential applications in multiple areas, such as audio-based surveillance, binaural hearing aids or advanced acoustic monitoring. The knowledge of the spatial position of a source of interest is usually a requirement for many of these applications. Therefore, source localization is an important problem to be addressed in WASNs. Unfortunately, most localization algorithms need costly signal processing stages that prevent them from being implemented in low-cost sensor networks, requiring additional modules for signal acquisition and processing. This paper presents a low-complexity method for acoustic event detection and localizati…
Psychoacoustic Annoyance Implementation With Wireless Acoustic Sensor Networks for Monitoring in Smart Cities
2020
Soundscape standard (ISO 12913) is mainly oriented to describe the psychoacoustic annoyance (PA) due to the perceived sound in different environments. The evaluation of this annoyance is commonly based on the Zwicker and Fastl model that defines several components related to this subjective annoyance, such as loudness, sharpness, roughness, and fluctuation strength. But due to their complexity, these components are difficult to be calculated on small board computers (SBCs) in real time in order to enable a wireless acoustic sensor network for PA monitoring. In this article, we describe the necessary procedures to implement the complete psychoacoustic model by Zwicker and Fastl in a precise …
5G IoT System for Real-Time Psycho-Acoustic Soundscape Monitoring in Smart Cities With Dynamic Computational Offloading to the Edge
2021
Environmental noise monitoring for smart cities need to be as much efficient as possible in order to mitigate its significant impact in the health of their inhabitants. 5G Internet of Things (IoT) systems offer a big opportunity to offload the computation from the sensor nodes, since it provides a series of new concepts for dynamic computing that the previous technologies did not offer. In this article, a complete 5G IoT system for psycho-acoustic monitoring has been designed and implemented using different options for offloading computation to different parts of the system. This offloading has been done by developing different functional splittings of the psycho-acoustic metrics algorithms…
A measurement-based channel model for vehicular communications in tunnels
2014
Wireless Communications and Networking Conference (WCNC), 2014 IEEE, Istanbul, TURQUIE, 06-/04/2014 - 09/04/2014; In this paper, we present a new version of the iterative nonlinear least square approximation (INLSA) algorithm for the design of measurement-based channel simulators. The proposed method aims to match the time-variant impulse response (TVIR) of the simulation model to that of the measured channel. The propagation delays are discerned directly from the measurements, whereas the gains, the Doppler frequencies, and the phases are computed iteratively by minimizing a matching error norm. We evaluate the performance of the proposed method in terms of the approximation of the transfe…