Search results for "Signal"
showing 10 items of 6924 documents
1H, 13C and 15N NMR chemical shift assignments of cAMP-regulated phosphoprotein-19 and -16 (ARPP-19 and ARPP-16)
2020
Protein Phosphatase 2A, PP2A, the principal Serine/threonine phosphatase, has major roles in broad range of signaling pathways that include regulation of cell cycle, cell proliferation and neuronal signaling. The loss of function of PP2A is linked with many human diseases, like cancer and neurodegenerative disorders. Protein phosphatase 2A (PP2A) functions as tumor suppressor and its tumor suppressor activity is inhibited by the overexpression of PP2A inhibitor proteins in most of the cancers. ARPP-19/ARPP-16 has been identified as one of the potential PP2A inhibitor proteins. Here, we report the resonance assignment of backbone 1H, 13C and 15N atoms of human ARPP-19 and ARPP-16 proteins. T…
SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus.
2006
Histone acetylation plays a key role in the regulation of gene expression. The chromatin structure and accessibility of genes to transcription factors is regulated by enzymes that acetylate and deacetylate histones. The Sin3A corepressor complex recruits histone deacetylases and in many cases represses transcription. Here, we report that SAP30L, a close homolog of Sin3-associated protein 30 (SAP30), interacts with several components of the Sin3A corepressor complex. We show that it binds to the PAH3/HID (Paired Amphipathic Helix 3/Histone deacetylase Interacting Domain) region of mouse Sin3A with residues 120–140 in the C-terminal part of the protein. We provide evidence that SAP30L induces…
Energy and environmental assessment of retrofit actions on a residential building
2014
Energy and environmental performances of buildings strictly depend on many factors related to the choice of construction materials, technical equipment, installation and use. In the following chapter a set of retrofit actions to improve the thermal performance of an existing conventional building is presented. The energy and environmental assessment of these actions is carried out following a life cycle approach. The embodied energy and the environmental impacts arisen from the production, transportation and installation phases of the required materials and components are calculated. Further, energy saving and environmental benefits and drawbacks concerning the assessed retrofit actions are…
MiR-33a Controls hMSCS Osteoblast Commitment Modulating the Yap/Taz Expression Through EGFR Signaling Regulation
2019
Mesenchymal stromal cells (hMSCs) display a pleiotropic function in bone regeneration. The signaling involved in osteoblast commitment is still not completely understood, and that determines the failure of current therapies being used. In our recent studies, we identified two miRNAs as regulators of hMSCs osteoblast differentiation driving hypoxia signaling and cytoskeletal reorganization. Other signalings involved in this process are epithelial to mesenchymal transition (EMT) and epidermal growth factor receptor (EGFR) signalings through the regulation of Yes-associated protein (YAP)/PDZ-binding motif (TAZ) expression. In the current study, we investigated the role of miR-33a family as a (…
Effects of combined hormone replacement therapy or its effective agents on the IGF-1 pathway in skeletal muscle.
2010
Objectives To investigate the effects of combined hormone replacement therapy (HRT) and its effective agents on the IGF-1 signaling pathway. Design and methods To examine the effects of HRT on skeletal muscle in vivo, we utilized pre- and post-intervention samples from a randomized double blinded trial with 50–57-year-old women. The intervention included the year-long use of either HRT preparation (2 mg 17β-estradiol, E2; 1 mg norethisterone acetate, NETA, n = 10) or placebo (CO, n = 9). Microarray technology and quantitative PCR (qPCR) were used to study the expression of insulin-like growth factor I (IGF-1) and its splice variants as well as IGF-1 receptor, Akt1, mTOR, FOXO1, FOXO3, atrog…
Movement Detection with Event-Based Cameras: Comparison with Frame-Based Cameras in Robot Object Tracking Using Powerlink Communication
2018
Event-based cameras are not common in industrial applications despite the fact that they can add multiple advantages for applications with moving objects. In comparison with frame-based cameras, the amount of generated data is very low while keeping the main information in the scene. For an industrial environment with interconnected systems, data reduction becomes very important to avoid network congestion and provide faster response time. However, the use of new sensors as event-based cameras is not common since they do not usually provide connectivity to industrial buses. This work develops a network node based on a Field Programmable Gate Array (FPGA), including data acquisition and trac…
Positive L1 observer design for positive Switched systems
2014
Published version of an article in the journal: Circuits, Systems, and Signal Processing. Also available from the publisher at: http://dx.doi.org/10.1007/s00034-013-9737-6 This paper investigates the problem of L1 observer design for positive switched systems. Firstly, a new kind of positive L1 observer is proposed for positive switched linear delay-free systems with observable and unobservable subsystems. Based on the average dwell time approach, a sufficient condition is proposed to ensure the existence of the positive L1 observer. Under the condition obtained, the estimated error converges to zero exponentially, and the L1 -gain from the disturbance input to the estimated error is less t…
Overview of ghost correction for HDR video stream generation
2015
International audience; Most digital cameras use low dynamic range image sensors, these LDR sensors can capture only a limited luminance dynamic range of the scene[1], to about two orders of magnitude (about 256 to 1024 levels). However, the dynamic range of real-world scenes varies over several orders of magnitude (10.000 levels). To overcome this limitation, several methods exist for creating high dynamic range (HDR) image (expensive method uses dedicated HDR image sensor and low-cost solutions using a conventional LDR image sensor). Large number of low-cost solutions applies a temporal exposure bracketing. The HDR image may be constructed with a HDR standard method (an additional step ca…
FLUMO: FLexible Underwater MOdem
2019
The last years have seen a growing interest in underwater acoustic communications because of its applications in marine research, oceanography, marine commercial operations, the offshore oil industry and defense. High-speed communication in the underwater acoustic channel has been challenging because of limited bandwidth, extended multipath, refractive properties of the medium, severe fading, rapid time variation and large Doppler shifts. In this paper, we show an implementation of a flexible Software-Defined Acoustic (SDA) underwater modem, where modulation parameters are completely tunable to optimize performance. In particular, we develop the system architecture following two key ideas. …
Cellular response to external signals in S. cerevisiae
2015
En esta tesis, se utilizó como organismo modelo la levadura Saccharomyces cerevisiae para obtener conocimiento fundamental sobre una variedad de mecanismos moleculares utilizados por la célula para responder y adaptarse a los estímulos externos. En respuesta al aumento de la osmolaridad externa, la ruta de señalización MAPK High Osmolarity Glycerol (HOG) se activa para mediar cambios en diversas funciones celulares, incluyendo la reprogramación global de la transcripción y traducción, con el fin último de lograr la adaptación. Tras la detección de alta osmolaridad externa, la señal se transduce a través de dos ramas funcionalmente redundantes pero mecanísticamente distintas, SLN1 y SHO1, pa…