Search results for "Signal"

The Immunostimulatory Function of IL-12 in T-Helper Cell Development and Its Regulation by TGF-β, IFN-γ and IL-4

1997

Bioelectric model of atrial fibrillation: Applicability of blind source separation techniques for atrial activity estimation in atrial fibrillation e…

2003

In this contribution, we present the theoretical justification that give support to the suitability of blind signal separation (BSS) techniques for the estimation of the atrial activity (AA) present in ECGs of persistent atrial fibrillation (AF). The application of BSS methods to this problem needs the fulfillment of several conditions regarding AA, ventricular activity (VA) and the fashion in which both activities arise on the body surface, that will be justified along the paper. To empirically validate the model, an ICA method is applied to 10 real 12-lead recordings of AF. The identification of AA is put forward based on kurtosis and spectral analysis. The kurtosis value of the estimated…

Single-trial-based Temporal Principal Component Analysis on Extracting Event-related Potentials of Interest for an Individual Subject

2021

Abstract Temporal principal component analysis (t-PCA) has been widely used to extract event-related potentials (ERPs) at the group level of multiple subjects’ ERP data. The key assumption of group t-PCA analysis is that desired ERPs of all subjects share the same waveforms (i.e., temporal components), whereas waveforms of different subjects’ ERPs can be variant in phases, peak latencies and so on, to some extent. Additionally, several PCA-extracted components coming from the same ERP dataset failed to be statistically analysed simultaneously because their polarities and amplitudes were indeterminate. To fill these gaps, a novel technique was proposed and employed to extract desired ERP fro…

Multi axis representation and Euclidean distance of muscle fatigue indexes during evoked contractions

2014

International audience; In this article, we proposed a new representation of muscular fatigue during evoked muscle contractions based on fatigue indexes such as peak to peak amplitude, RMS of the M wave, mean and median frequency and fatigue index calculated from continuous wavelet transform (I CWT). These new representations of muscle fatigue using multi axis represented and Euclidean distance give better insights on changes in physiological characteristics during muscle fatigue. This technique provides a fatigue index using several muscle characteristics. The use of other kinds of fatigue characteristics as force could also be possible.

Measuring Functional Connectivity of Human Intra-Cortex Regions with Total Correlation

2021

The economy of brain organization makes the primate brain consume less energy but efficiency. The neurons densely wired each other dependent on both anatomy structure connectivity and functional connectivity. Here, I only describe functional connectivity with Functional Magnetic Resonance Imaging (fMRI) data. Most importantly, how to quantitative measure information share or separate among functional brain regions, what’s worse, fMRI data exist large dimensional problems or “curse dimensionality” [1]. However, the multivariate total correlation method can perfectly address the above problems. In this paper, two things measured with the information-theoretic technique - total correlation [2,…

P087 Increased wnt ligands expression in M2c macrophages is associated with fibrosis in Stat6 knockout mice

2017

Mucin 1 downregulation associates with corticosteroid resistance in chronic rhinosinusitis with nasal polyps

2013

Background A number of patients with chronic rhinosinusitis with nasal polyps (CRSwNP) are resistant to oral corticosteroids. Mucin 1 (MUC1) shows anti-inflammatory properties, and its cytoplasmic tail (CT) interacts with transcription factors, facilitating their nuclear translocation. Because glucocorticoid receptor (GR) nuclear translocation is key to the anti-inflammatory effect of corticosteroids, we hypothesized that MUC1 is involved in the effectiveness of corticosteroids. Objective To analyze the role of MUC1 in corticosteroid effectiveness in different cohorts of patients with CRSwNP and elucidate the possible mechanisms involved. Methods Seventy-three patients with CRSwNP took oral…

BCR-ABL as a target for novel therapeutic interventions.

2002

The BCR-ABL oncogene is the result of a reciprocal translocation between the long arms of chromosome 9 and 22 t(9; 22). There is good experimental evidence demonstrating that BCR-ABL is the single causative abnormality in chronic myeloid leukaemia (CML), making it a unique model for the development of molecular targets. In addition to CML, BCR-ABL transcripts can be found in a minority of acute lymphoblastic leukaemias and very rarely in acute myeloid leukaemia (AML). Elucidating the molecular mechanisms and downstream pathways of BCR-ABL has led to the design of several novel therapeutic approaches. In this review, molecular targeting of BCR-ABL will be discussed based on the inhibition of…

Anti-endothelin drugs in solid tumors

2010

Importance of the field: The endothelin (ET) axis, which includes the biological functions of ETs and their receptors, has played a physiological role in normal tissue, acting as a modulator of vasomotor tone, tissue differentiation and development, cell proliferation and hormone production. Interestingly, it also functions in the growth and progression of various tumors. Several researchers have identified the blockade of the ET-1 receptor as a promising therapeutic approach. Areas covered in this review: The clinical investigation of an orally bioavailable ET antagonist, atrasentan, in prostate cancer, is encouraging. In this neoplasia, it has shown antitumor activity, bone metastasis con…

A boosting approach for prostate cancer detection using multi-parametric MRI

2015

International audience; Prostate cancer has been reported as the second most frequently diagnosed men cancers in the world. In the last decades, new imaging techniques based on MRI have been developed in order to improve the diagnosis task of radiologists. In practise, diagnosis can be affected by multiple factors reducing the chance to detect potential lesions. Computer-aided detection and computer-aided diagnosis have been designed to answer to these needs and provide help to radiologists in their daily duties. In this study, we proposed an automatic method to detect prostate cancer from a per voxel manner using 3T multi-parametric Magnetic Resonance Imaging (MRI) and a gradient boosting …