Search results for "Signal"
showing 10 items of 6924 documents
Fractalkine Signaling and Microglia Functions in the Developing Brain.
2015
Microglial cells are the resident macrophages of the central nervous system (CNS). Besides their classical roles in pathological conditions, these immune cells also dynamically interact with neurons and influence their structure and function in physiological conditions. The neuronal chemokine fractalkine and its microglial receptor CX3CR1 are one important signaling pathway involved in these reciprocal interactions. In the present review, we will discuss recent evidence indicating that fractalkine signaling also determines several functions of microglial cells during normal CNS development. It has been known for a decade that microglial cells influence the neuronal death that normally occur…
Nicotinic receptor agonists as neuroprotective/neurotrophic drugs. Progress in molecular mechanisms
2007
In the present work we reviewed recent advances concerning neuroprotective/neurotrophic effects of acute or chronic nicotine exposure, and the signalling pathways mediating these effects, including mechanisms implicated in nicotine addiction and nAChR desensitization. Experimental and clinical data largely indicate long-lasting effects of nicotine and nicotinic agonists that imply a neuroprotective/neurotrophic role of nAChR activation, involving mainly alpha 7 and alpha 4 beta 2 nAChR subtypes, as evidenced using selective nAChR agonists. Compounds interacting with neuronal nAChRs have the potential to be neuroprotective and treatment with nAChR agonists elicits long-lasting neurotrophic e…
Search for a diffuse flux of high-energy ¿µ with the ANTARES neutrino telescope
2011
A search for a diffuse flux of astrophysical muon neutrinos, using data collected by the ANTARES neutrino telescope is presented. A $(0.83\times 2\pi)$ sr sky was monitored for a total of 334 days of equivalent live time. The searched signal corresponds to an excess of events, produced by astrophysical sources, over the expected atmospheric neutrino background. The observed number of events is found compatible with the background expectation. Assuming an $E^{-2}$ flux spectrum, a 90% c.l. upper limit on the diffuse $\nu_\mu$ flux of $E^2\Phi_{90%} = 5.3 \times 10^{-8} \ \mathrm{GeV\ cm^{-2}\ s^{-1}\ sr^{-1}} $ in the energy range 20 TeV - 2.5 PeV is obtained. Other signal models with differ…
GW170817: Observation of Gravitational Waves from a Binary Neutron Star Inspiral
2017
On August 17, 2017 at 12-41:04 UTC the Advanced LIGO and Advanced Virgo gravitational-wave detectors made their first observation of a binary neutron star inspiral. The signal, GW170817, was detected with a combined signal-to-noise ratio of 32.4 and a false-alarm-rate estimate of less than one per 8.0×104 years. We infer the component masses of the binary to be between 0.86 and 2.26 M, in agreement with masses of known neutron stars. Restricting the component spins to the range inferred in binary neutron stars, we find the component masses to be in the range 1.17-1.60 M, with the total mass of the system 2.74-0.01+0.04M. The source was localized within a sky region of 28 deg2 (90% probabili…
Role of the NF-kB pathway and nitric oxide in mammary gland involution after weaning. Implications in breast cancer
2013
INTRODUCCIÓN La glándula mamaria es un órgano dinámico que alcanza su máximo desarrollo funcional con la lactancia, momento en el cual, a través de la producción de leche, aporta nutrientes y protección inmunológica a las crías de los mamíferos. Cuando la lactancia finaliza con el destete, el exceso de tejido glandular debe desaparecer y la glándula sufre una extensa remodelación hasta alcanzar nuevamente un estado pre-gestacional, preparada para un nuevo ciclo. La involución del tejido mamario es un proceso complejo durante el cual se suceden de forma coordinada una serie de eventos como la muerte de las células epiteliales secretoras, la proliferación de tejido adiposo circundante y la re…
It takes time to see the menu from the body: an experiment on stable isotope composition in freshwater crayfishes
2015
For many applications and ecological studies in which wild individuals are brought to laboratory it would be essential to know accurately how fast novel diet is reflected in composition of different tissues. To study the effects of two different diets on the stable isotope composition of freshwater crayfish muscle and hemolymph, we conducted a three month experiment on noble crayfish (Astacus astacus) and signal crayfish (Pacifastacus leniusculus) by feeding them sweet corn (Zea mays) or Baltic herring (Clupea harengus membras) as novel food. During the experiment, the crayfish were given 0.4 g of selected food daily and the amount consumed was recorded. The samples for the stable isotope a…
Noise Reduction and Gap Filling of fAPAR Time Series Using an Adapted Local Regression Filter
2014
Time series of remotely sensed data are an important source of information for understanding land cover dynamics. In particular, the fraction of absorbed photosynthetic active radiation (fAPAR) is a key variable in the assessment of vegetation primary production over time. However, the fAPAR series derived from polar orbit satellites are not continuous and consistent in space and time. Filtering methods are thus required to fill in gaps and produce high-quality time series. This study proposes an adapted (iteratively reweighted) local regression filter (LOESS) and performs a benchmarking intercomparison with four popular and generally applicable smoothing methods: Double Logistic (DLOG), sm…
Thermal noise limit for ultra-high vacuum noncontact atomic force microscopy
2013
The noise of the frequency-shift signal Δf in noncontact atomic force microscopy (NC-AFM) consists of cantilever thermal noise, tip–surface-interaction noise and instrumental noise from the detection and signal processing systems. We investigate how the displacement-noise spectral density dz at the input of the frequency demodulator propagates to the frequency-shift-noise spectral density dΔf at the demodulator output in dependence of cantilever properties and settings of the signal processing electronics in the limit of a negligible tip–surface interaction and a measurement under ultrahigh-vacuum conditions. For a quantification of the noise figures, we calibrate the cantilever displacemen…
Ghost stochastic resonance in FitzHugh–Nagumo circuit
2014
International audience; The response of a neural circuit submitted to a bi-chromatic stimulus and corrupted by noise is investigated. In the presence of noise, when the spike firing of the circuit is analysed, a frequency not present at the circuit input appears. For a given range of noise intensities, it is shown that this ghost frequency is almost exclusively present in the interspike interval distribution. This phenomenon is for the first time shown experimentally in a FitzHugh-Nagumo circuit.
Theoretical Models of Industrial Espionage
2012
Dada la importancia del espionaje industrial en la realidad económica, el objetivo de la presente tesis es analizar teóricamente el comportamiento de las empresas a la hora de obtener información de sus competidores, para poder comprenderlo mejor y ver cuáles pueden ser sus consecuencias, ya que, aunque el espionaje industrial es una práctica muy extendida, pocos trabajos teóricos han tratado de analizarlo. Más concretamente, nuestro objetivo es analizar teóricamente el impacto del espionaje industrial sobre el comportamiento estratégico de las empresas en un contexto de disuasión de la entrada usando las herramientas propias de la Teoría de Juegos. En los modelos de la presente tesis se co…