Search results for "Signal"
showing 10 items of 6924 documents
PTC124-mediated translational readthrough of a nonsense mutation causing Usher syndrome type 1C.
2011
We investigated the therapeutic potential of the premature termination codon (PTC) readthrough-inducing drug PTC124 in treating the retinal phenotype of Usher syndrome, caused by a nonsense mutation in the USH1C gene. Applications in cell culture, organotypic retina cultures, and mice in vivo revealed significant readthrough and the recovery of protein function. In comparison with other readthrough drugs, namely the clinically approved readthrough-inducing aminoglycoside gentamicin, PTC124 exhibits significant better retinal biocompatibility. Its high readthrough efficiency in combination with excellent biocompatibility makes PTC124 a promising therapeutic agent for PTCs in USH1C, as well a…
Sélection de bandes pour la visualisation d'images spectrales : une approche basée sur l'étude de saillance
2011
National audience; De nos jours, la plupart des technologies d'affichage numériques sont basées sur le paradigme qu'une combinaison de trois couleurs primaires spécifiques est suffisante pour la reproduction d'une couleur quelconque pour l'oeil humain. Par ailleurs, les dispositifs d'affichage multispectraux ne sont pas encore monnaie courante sur le marché du multimédia. Ainsi, lorsqu'il s'agit de visualiser une image spectrale en couleur, sur un écran traditionnel, seuls trois bandes peuvent être utilisées simultanément, ce qui implique une réduction de dimensionnalité. Cette étape doit permettre la préservation d'un maximum de contenu informatif tout en préservant contrastes et couleurs …
Sing and Measure: Sound as Voice as Quanta
2022
The universal concept of a “music of the spheres” traverses the history of philosophy, science and art, from Pythagoras to Kepler and beyond. In modern times, a sphere in three dimensions—the Bloch sphere—is used to illustrate the state of a qubit, the basic unit of quantum information. On the same spherical surface, the fundamental components of voice production can be located, so that any utterance can be seen as the evolution of a unit two-dimensional vector having complex coefficients. Indeed, any sound can be analyzed and decomposed into overlapping sinusoidal components, broadband noises, and impulsive transients, which in turn can be associated to fundamental means of vocal sound pro…
Experimental Validation of Maximum Constant Boost Control and Switching Frequency Optimal for three-phase Quasi-Z-Source Converters
2020
This paper presents a modified modulation scheme for quasi-Z-Source converters, based on the Maximum Constant Boost Control (MCBC) concept and Switching Frequency Optimal (SFO) as reference signal. The effectiveness of the proposed technique is validated by comparing the obtained results (in terms of AC harmonic content and voltage stress) with those carried out from traditional modulation schemes. For this reason, a test bench has been assembled and the benefits of the SFO MCBC modulation scheme have been valuated.
Relationship between volume and energy of vector fields
2001
Abstract A unified study of energy and volume functionals is presented here by determining the critical points of a functional that extends simultaneously energy and volume and that is defined on the product of the manifold of smooth maps C∞(M,N) times the manifold M of riemannian metrics on M. The restriction of this functional to different submanifolds of the space of vector fields X (M)× M is also considered, and used to study several functionals generalizing volume and energy or total bending of vector fields
Multimodal Aposematic Signals and Their Emerging Role in Mate Attraction
2018
Chemically defended animals often display conspicuous color patterns that predators learn to associate with their unprofitability and subsequently avoid. Such animals (i.e., aposematic), deter predators by stimulating their visual and chemical sensory channels. Hence, aposematism is considered to be “multimodal.” The evolution of warning signals (and to a lesser degree their accompanying chemical defenses) is fundamentally linked to natural selection by predators. Lately, however, increasing evidence also points to a role of sexual selection shaping warning signal evolution. One of the species in which this has been shown is the wood tiger moth, Arctia plantaginis, which we here put forward…
System wczesnego ostrzegania w zarządzaniu projektami jako narzędzie wspomagania osiągania sukcesu projektu
2020
Celem artykułu jest zaprezentowanie istoty systemów wczesnego ostrzegania w zarządzaniu projektami w kontekście osiągania celów projektów. Potrzeba stosowania narzędzi wczesnego ostrzegania w zarządzaniu projektami ma uzasadnienie przede wszystkim w fakcie, że z reguły (pomijając zdarzenia nadzwyczajne) przedsiębiorstwa wykazują objawy sytuacji kryzysowych w realizacji podejmowanych projektów na długo przedtem zanim dojdzie do niepowodzenia projektu. Wczesne zidentyfikowanie sygnałów zbliżającego się kryzysu powinno być zatem jednym z podstawowych zadań w zarządzaniu projektami. W artykule omówiono rolę systemu wczesnego ostrzegania oraz jego funkcje. Wskazano na zastosowania systemów wczes…
Webcam based display calibration
2012
International audience; We present an automatic method for measuring the tone response curve of display devices based on visual methods, where the eye is replaced by an end-user, uncalibrated camera, such as a webcam. Our approach compares a series of halftoned patches of known covering ratio with a continuous series of tone patches for each ratio. Both patches are shot by a camera that is used as a virtual eye to evaluate the luminance difference. By an iterative process, the continuous tone value is adjusted while compared with the perceived level of the halftoned patch. When the camera does not see any difference between the patches or a minimal difference, the luminance level of the con…
Deformation Quantization in White Noise Analysis
2007
We define and present an example of a deformation quantization product on a Hida space of test functions endowed with a Wick product.
The mitogen-activated protein kinase p38 pathway is conserved in metazoans: Cloning and activation of p38 of the SAPK2 subfamily from the sponge Sube…
2000
Our recent data suggest that during auto- and allograft recognition in sponges (Porifera), cytokines are differentially expressed. Since the mitogen-activated protein kinase (MAPK) signal transduction modulates the synthesis and release of cytokines, we intended to identify one key molecule of this pathway. Therefore, a cDNA from the marine sponge Suberites domuncula encoding the MAPK was isolated and analyzed. Its encoded protein is 366 amino acids long (calculated Mr 42 209), has a TGY dual phosphorylation motif in protein kinase subdomain VIII and displays highest overall similarity to the mammalian p38 stress activated protein kinase (SAPK2), one subfamily of MAPKs. The sponge protein w…