Search results for "Simulation."

showing 10 items of 4779 documents

Comparison of hemodynamic and structural indices of ascending thoracic aortic aneurysm as predicted by 2-way FSI, CFD rigid wall simulation and patie…

2018

Patient-specific computational modeling is increasingly being used to predict structural and hemodynamic parameters, especially when current clinical tools are not accessible. Indeed, pathophysiology of ascending thoracic aortic aneurysm (ATAA) has been simulated to quantify the risk of complications by novel prognostic parameters and thus to improve the clinical decision-making process related to the intervention of ATAAs. In this study, the relevance of aneurysmal wall elasticity in determining parameters of clinical importance, such as the wall shear stress (WSS), is discussed together with the significance of applying realistic boundary conditions to consider the aortic stretch and twis…

Aortic valveAdultMalePatient-Specific Modelingmedicine.medical_specialtyComputer science0206 medical engineeringFinite Element Analysisaorti failureHeart Valve DiseasesHemodynamicsFluid-solid interaction (FSI)Health Informatics02 engineering and technology030204 cardiovascular system & hematologyComputational fluid dynamicsThoracic aortic aneurysm03 medical and health sciences0302 clinical medicineBicuspid aortic valveBicuspid Aortic Valve DiseaseInternal medicinemedicineShear stressHumansComputer SimulationAgedAortic Aneurysm ThoracicStructural mechanicsbusiness.industryFinite element analysis (FEA)Models CardiovascularMiddle Agedmedicine.diseaseAscending thoracic aortic aneurysm020601 biomedical engineeringFinite element methodElasticityComputer Science Applicationsmedicine.anatomical_structureComputational fluid-dynamic (CFD)Aortic Valvecardiovascular systemCardiologyFemaleStress Mechanicalbusiness
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Modified nonsink equation for permeability estimation in cell monolayers: comparison with standard methods.

2014

Cell culture permeability experiments are valuable tools in drug development and candidate selection, but the monolayer preparation protocols and the calculations procedures can affect the permeability estimation. Hence, standardization and method suitability demonstration are necessary steps for using permeability data for regulatory and in vivo prediction purposes. Much attention is usually paid to experimental procedure validation and less to the mathematical analysis of the results although the standard equations used imply several assumptions that many times do not hold. The aim of this study was to use a simulation strategy to explore the performance of a new proposed modified nonsink…

Apparent permeabilityAnalytical chemistryPharmaceutical ScienceRegression analysisPermeationStandard methodsModels TheoreticalPermeabilityPermeability (earth sciences)Drug DiscoveryLinear regressionModel simulationMolecular MedicineRegression AnalysisBiological systemMathematicsMolecular pharmaceutics
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Ejection and collision orbits of the spatial restricted three-body problem

1985

We begin by describing the global flow of the spatial two body rotating problem, μ=0. The remainder of the work is devoted to study the ejection and collision orbits when μ>-0. We make use of the ‘blow up’ techniques to show that for any fixed value of the Jacobian constant the set of these orbits is diffeomorphic to S2×R. Also we find some particular collision-ejection orbits.

Applied MathematicsAstronomy and AstrophysicsTwo-body problemThree-body problemCollisionCelestial mechanicsComputational Mathematicssymbols.namesakeClassical mechanicsSpace and Planetary ScienceModeling and SimulationAutomotive EngineeringJacobian matrix and determinantsymbolsOrbit (dynamics)Astrophysics::Earth and Planetary AstrophysicsRemainderConstant (mathematics)Mathematical PhysicsMathematicsCelestial Mechanics
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Fixed point theorems on ordered metric spaces and applications to nonlinear elastic beam equations

2012

In this paper, we establish certain fixed point theorems in metric spaces with a partial ordering. Presented theorems extend and generalize several existing results in the literature. As application, we use the fixed point theorems obtained in this paper to study existence and uniqueness of solutions for fourth-order two-point boundary value problems for elastic beam equations.

Applied MathematicsMathematical analysisFixed-point theoremFixed-point propertyNonlinear systemMetric spaceSettore MAT/05 - Analisi MatematicaModeling and SimulationGeometry and TopologyBoundary value problemUniquenessOrdered metric space fixed point coupled fixed point boundary value problem elastic beam equation.Partially ordered setCoincidence pointMathematics
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On a new proof of Moser's twist mapping theorem

1976

Based on a new idea of the author, a new proof of J. Moser's twist mapping theorem is presented.

Applied MathematicsMathematical analysisMathematics::Analysis of PDEsAstronomy and AstrophysicsAlgebraComputational MathematicsTheoryofComputation_MATHEMATICALLOGICANDFORMALLANGUAGESNonlinear Sciences::Exactly Solvable and Integrable SystemsSpace and Planetary ScienceModeling and SimulationComputingMethodologies_SYMBOLICANDALGEBRAICMANIPULATIONAutomotive EngineeringTwistMathematical PhysicsComputingMethodologies_COMPUTERGRAPHICSMathematicsCelestial Mechanics
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ANALYSIS OF A SPHERICAL HARMONICS EXPANSION MODEL OF PLASMA PHYSICS

2004

A spherical harmonics expansion model arising in plasma and semiconductor physics is analyzed. The model describes the distribution of particles in the position-energy space subject to a (given) electric potential and consists of a parabolic degenerate equation. The existence and uniqueness of global-in-time solutions is shown by semigroup theory if the particles are moving in a one-dimensional interval with Dirichlet boundary conditions. The degeneracy allows to show that there is no transport of particles across the boundary corresponding to zero energy. Furthermore, under certain conditions on the potential, it is proved that the solution converges in the long-time limit exponentially f…

Applied MathematicsMathematical analysisZonal spherical harmonicsBoundary (topology)Spherical harmonicssymbols.namesakeModeling and SimulationDirichlet boundary conditionSpin-weighted spherical harmonicssymbolsVector spherical harmonicsUniquenessMathematicsSolid harmonicsMathematical Models and Methods in Applied Sciences
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Figures of equilibrium in close binary systems

1992

The equilibrium configurations of close binary systems are analyzed. The autogravitational, centrifugal and tidal potentials are expanded in Clairaut's coordinates. From the set of the total potential angular terms an integral equations system is derived. The reduction of them to ordinary differential equations and the determination of the boundary conditions allow a formulation of the problem in terms of a single variable.

Applied MathematicsMathematical analysisfigure of celestial bodiesspherical harmonicsBinary numberSpherical harmonicsAstronomy and AstrophysicsIntegral equationCelestial mechanicsComputational MathematicsClassical mechanicsSpace and Planetary ScienceModeling and SimulationOrdinary differential equationPoisson equationsclose binary starsBoundary value problemPoisson's equationReduction (mathematics)Mathematical PhysicsMathematicsCelestial Mechanics and Dynamical Astronomy
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A strain-difference-based nonlocal elasticity model

2004

Abstract A two-component local/nonlocal constitutive model for (macroscopically) inhomogeneous linear elastic materials (but constant internal length) is proposed, in which the stress is the sum of the local stress and a nonlocal-type stress expressed in terms of the strain difference field, hence identically vanishing in the case of uniform strain. Attention is focused upon the particular case of piecewise homogeneous material. The proposed model is thermodynamically consistent with a suitable free energy potential. It constitutes an improved form of the Vermeer and Brinkgreve [A new effective nonlocal strain measure for softening plasticity. In: Chambon, R., Desrues, J., Vardulakis, I. (E…

Applied MathematicsMechanical EngineeringAttenuationMathematical analysisConstitutive equationLinear elasticityGeometryPlasticityCondensed Matter PhysicsBifurcation theoryMechanics of MaterialsModeling and SimulationPiecewiseGeneral Materials ScienceSofteningMathematicsNumerical stabilityInternational Journal of Solids and Structures
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Nonlocal elasticity and related variational principles

2001

Abstract The Eringen model of nonlocal elasticity is considered and its implications in solid mechanics studied. The model is refined by assuming an attenuation function depending on the `geodetical distance' between material particles, such that in the diffusion processes of the nonlocality effects certain obstacles as holes or cracks existing in the domain can be circumvented. A suitable thermodynamic framework with nonlocality is also envisaged as a firm basis of the model. The nonlocal elasticity boundary-value problem for infinitesimal displacements and quasi-static loads is addressed and the conditions for the solution uniqueness are established. Three variational principles, nonlocal…

Applied MathematicsMechanical EngineeringCondensed Matter PhysicsFinite element methodQuantum nonlocalityClassical mechanicsMechanics of MaterialsVariational principleModeling and SimulationSolid mechanicsGeneral Materials ScienceDirect stiffness methodUniquenessElasticity (economics)MathematicsStiffness matrixInternational Journal of Solids and Structures
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Gradient elasticity and nonstandard boundary conditions

2003

Abstract Gradient elasticity for a second gradient model is addressed within a suitable thermodynamic framework apt to account for nonlocality. The pertinent thermodynamic restrictions upon the gradient constitutive equations are derived, which are shown to include, besides the field (differential) stress–strain laws, a set of nonstandard boundary conditions. Consistently with the latter thermodynamic requirements, a surface layer with membrane stresses is envisioned in the strained body, which together with the above nonstandard boundary conditions make the body constitutively insulated (i.e. no long distance energy flows out of the boundary surface due to nonlocality). The total strain en…

Applied MathematicsMechanical EngineeringConstitutive equationGeometryMechanicsEquilibrium equationCondensed Matter PhysicsTotal strainMinimum total potential energy principleQuantum nonlocalityMechanics of MaterialsModeling and SimulationGeneral Materials ScienceBoundary value problemSurface layerElasticity (economics)MathematicsInternational Journal of Solids and Structures
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