Search results for "Simulation."

A Case for Raising the Camera: A Driving Simulator Test of Camera-Monitor Systems

2021

Objective This experiment provides a first-of-its-kind driving-simulator study to investigate the feasibility of camera-monitor systems (CMS) with displaced side-mounted cameras in sedans. Background Among the increasing number of studies investigating the replacement of side-mounted rearview mirrors with CMS, the placement of side-mounted cameras has been largely neglected. Moreover, user preferences with respect to camera placement have not been validated in a driving simulator. Past research merely has shown that the vertical camera position can affect distance perception. Method In a driving simulator experiment, we investigated the effects of rearward camera placement on driver accepta…

The Influence of Human Walking Activities on the Doppler Characteristics of Non-stationary Indoor Channel Models

2019

This paper analyzes the time-variant (TV) Doppler power spectral density of a 3D non-stationary fixed-to-fixed indoor channel simulator after feeding it with realistic trajectories of a walking person. The trajectories of the walking person are obtained by simulating a full body musculoskeletal model in OpenSim. We provide expressions of the TV Doppler frequencies caused by these trajectories. Then, we present the complex channel gain consisting of fixed scatterers and a cluster of moving scatterers. After that, we use the concept of the spectrogram to analyze the TV Doppler power spectral density of the complex channel gain. Finally, we present expressions of the TV mean Doppler shift and …

Hierarchical modeling for rare event detection and cell subset alignment across flow cytometry samples.

2013

Flow cytometry is the prototypical assay for multi-parameter single cell analysis, and is essential in vaccine and biomarker research for the enumeration of antigen-specific lymphocytes that are often found in extremely low frequencies (0.1% or less). Standard analysis of flow cytometry data relies on visual identification of cell subsets by experts, a process that is subjective and often difficult to reproduce. An alternative and more objective approach is the use of statistical models to identify cell subsets of interest in an automated fashion. Two specific challenges for automated analysis are to detect extremely low frequency event subsets without biasing the estimate by pre-processing…

Errors Arising in Computer Simulation Methods

2014

The goal of this introductory chapter is to discuss in general terms different classes of errors arising in computer simulation methods and to direct the reader to the chapters and sections of the book where these errors are analyzed. Moreover, we describe the error estimation methodology applied in this book.

Dynamic-shared Pharmacophore Approach as Tool to Design New Allosteric PRC2 Inhibitors, Targeting EED Binding Pocket.

2020

Abstract: The Polycomb Repressive complex 2 (PRC2) maintains a repressive chromatin state and silences many genes, acting as methylase on histone tails. This enzyme was found overexpressed in many types of cancer. In this work, we have set up a Computer-Aided Drug Design approach based on the allosteric modulation of PRC2. In order to minimize the possible bias derived from using a single set of coordinates within the protein-ligand complex, a dynamic workflow was developed. In details, molecular dynamic was used as tool to identify the most significant ligand-protein interactions from several crystallized protein structures. The identified features were used for the creation of dynamic pha…

2019

This paper describes a single body-mounted sensor that integrates accelerometers, gyroscopes, compasses, barometers, a GPS receiver, and a methodology to process the data for biomechanical studies. The sensor and its data processing system can accurately compute the speed, acceleration, angular velocity, and angular orientation at an output rate of 400 Hz and has the ability to collect large volumes of ecologically-valid data. The system also segments steps and computes metrics for each step. We analyzed the sensitivity of these metrics to changing the start time of the gait cycle. Along with traditional metrics, such as cadence, speed, step length, and vertical oscillation, this system est…

An omics perspective to the molecular mechanisms of anticancer metallo-drugs in the computational microscope era

2017

Introduction: Metallo-drugs have attracted enormous interest for cancer treatment. The achievements of this drug-type are summarized by the success story of cisplatin. That being said, there have been many drawbacks with its clinical use, which prompted decades worth of research efforts to move towards safer and more effective agents, either containing platinum or different metals. Areas covered: In this review, the authors provide an atomistic picture of the molecular mechanisms involving selected metallo-drugs from structural and molecular simulation studies. They also provide an omics perspective, pointing out many unsettled aspects of the most relevant families of metallo-drugs at an ep…

An abstract inf-sup problem inspired by limit analysis in perfect plasticity and related applications

2021

This paper is concerned with an abstract inf-sup problem generated by a bilinear Lagrangian and convex constraints. We study the conditions that guarantee no gap between the inf-sup and related sup-inf problems. The key assumption introduced in the paper generalizes the well-known Babuška–Brezzi condition. It is based on an inf-sup condition defined for convex cones in function spaces. We also apply a regularization method convenient for solving the inf-sup problem and derive a computable majorant of the critical (inf-sup) value, which can be used in a posteriori error analysis of numerical results. Results obtained for the abstract problem are applied to continuum mechanics. In particular…

Elaboración y validación biomecánica de un guante de protección para jugar a pelota valenciana. (Elaboration and biomechanical validation of a protec…

2012

ResumenLa pelota valenciana es uno de los antiguos juegos de pelota a mano que perdura en la Comunidad Valenciana. Para amortiguar los impactos de la pelota durante el golpeo, los jugadores se confeccionan sus propias protecciones. En torno a ellas existen diversos factores que dificultan la práctica segura y eficaz de este deporte: el excesivo tiempo empleado en su elaboración, el elevado número de lesiones que sufren en las manos o el inadecuado control de la pelota que consiguen. En base a esto y a la inexistencia de un equipamiento deportivo específico para la mano, se ha desarrollado y validado un guante para intentar solventar estos inconvenientes. En la validación biomecánica se comp…

Representation of NURBS surfaces by Controlled Iterated Functions System automata

2019

Iterated Function Systems (IFS) are a standard tool to generate fractal shapes. In a more general way, they can represent most of standard surfaces like Bézier or B-Spline surfaces known as self-similar surfaces. Controlled Iterated Function Systems (CIFS) are an extension of IFS based on automata. CIFS are basically multi-states IFS, they can handle all IFS shapes but can also manage multi self-similar shapes. For example CIFS can describe subdivision surfaces around extraordinary vertices whereas IFS cannot. Having a common CIFS formalism facilitates the development of generic methods to manage interactions (junctions, differences...) between objects of different natures.This work focuses…