Search results for "Simulation"
showing 10 items of 5095 documents
Multi-subject fMRI analysis via combined independent component analysis and shift-invariant canonical polyadic decomposition
2014
Canonical polyadic decomposition (CPD) may face a local optimal problem when analyzing multi-subject fMRI data with inter-subject variability. Beckmann and Smith proposed a tensor PICA approach that incorporated an independence constraint to the spatial modality by combining CPD with ICA, and alleviated the problem of inter-subject spatial map (SM) variability.This study extends tensor PICA to incorporate additional inter-subject time course (TC) variability and to connect CPD and ICA in a new way. Assuming multiple subjects share common TCs but with different time delays, we accommodate subject-dependent TC delays into the CP model based on the idea of shift-invariant CP (SCP). We use ICA …
Space syntax analysis applied to urban street lighting: Relations between spatial properties and lighting levels
2019
According to the international technical standards, higher lighting levels (luminance and illuminance levels) are expected in trafficked and central roads (where restrictive minimum lighting requirements are necessary) and lower lighting levels are expected in peripheral and less trafficked roads. Starting from this assumption, in this paper, the authors analyse the correlations between spatial properties (expressed by spatial indicators, for example, the integration index and the choice index) and lighting levels (expressed by lighting parameters, for example luminance and illuminance) upon roads of an urban context. The analysis has been applied to the case study of the medium sized town …
A J-MADeM Agent-Based Social Simulation to Model Urban Mobility
2011
The mobility models followed within metropolitan areas, mainly based on the massive use of the car instead of the public transportation, will soon become unsustainable unless there is a change of citizens’ minds and transport policies. The main challenge related to urban mobility is that of getting free-flowing greener cities, which are provided with a smarter and accessible urban transport system. In this paper, we present an agent-based social simulation approach to tackle this kind of social-ecological systems. The Jason Multi-modal Agent Decision Making (JMADeM) library enable us to model and implement the social decisions made by each habitant about how to get to work every day, e.g., …
Molecular modeling approaches in the discovery of new drugs for anti-cancer therapy: the investigation of p53-MDM2 interaction and its inhibition by …
2010
The mdm2 oncogene product, MDM2, is an ubiquitin protein ligase that inhibits the transcriptional activity of the tumor suppressor p53 and promotes its degradation. About 50% of all human cancers present mutations or deletions in the TP53 gene. In the remaining half of all human neoplasias that express the wild-type protein, aberrations of p53 regula- tors, such as MDM2, account for p53 inhibition. For this reason, designing small-molecule inhibitors of the p53-MDM2 protein-protein interaction is a promising strategy for the treatment of cancers retaining wild-type p53. The development of inhibitors has been challenging. Although many small-molecule MDM2 inhibitors have shown potent in vitr…
A New Oxadiazole-Based Topsentin Derivative Modulates Cyclin-Dependent Kinase 1 Expression and Exerts Cytotoxic Effects on Pancreatic Cancer Cells
2021
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal form of cancer characterized by drug resistance, urging new therapeutic strategies. In recent years, protein kinases have emerged as promising pharmacological targets for the treatment of several solid and hematological tumors. Interestingly, cyclin-dependent kinase 1 (CDK1) is overexpressed in PDAC tissues and has been correlated to the aggressive nature of these tumors because of its key role in cell cycle progression and resistance to the induction of apoptosis. For these reasons, CDK1 is one of the main causes of chemoresistance, representing a promising pharmacological target. In this study, we report the synthesis of new 1,2,4…
Experiment of Indoor Thermal Optimization of an Old Historic Building of Cluny through Digital Mock-up Simulation
2013
International audience; Improving energy efficiency is the first and most important step toward achieving sustainability in buildings. Buildings designed with sustainable solutions are usually energy-efficient because sustainable design is aimed at producing green buildings. In the case of historic buildings, however, this is quite challenging. Integrated building energy simulation programs have been used in various ways by building professionals to respond to these challenges and to improve building design with respect to sustainability. This poster presents a new approach toward optimizing thermal indoor energy using a digital mock-up simulation of a historical building to explore its pot…
Valutazione della bontà di una recente misura di ineguaglianza: uno studio di simulazione
2010
La misura di ineguaglianza proposta da Zenga (2007) per valutare il grado di concentrazione della ricchezza è valutata attraverso studi di simulazione. Tali studi riferiti anche come metodo di Monte Carlo, sono usati per investigare il comportamento di metodi statistici e misure sotto situazioni controllate, quando l’approccio analitico è complesso.
The origin of in-plane stresses in axially moving orthotropic continua
2016
In this paper, we address the problem of the origin of in-plane stresses in continuous, two-dimensional high-speed webs. In the case of thin, slender webs, a typical modeling approach is the application of a stationary in-plane model, without considering the effects of the in-plane velocity field. However, for high-speed webs this approach is insufficient, because it neglects the coupling between the total material velocity and the deformation experienced by the material. By using a mixed Lagrange–Euler approach in model derivation, the solid continuum problem can be transformed into a solid continuum flow problem. Mass conservation in the flow problem, and the behaviour of free edges in th…
INVESTIGATIONS ON INFILTRATION METHODS FOR AN IMPROVED SOIL HYDRAULIC CHARACTERIZATION
2020
A Naïve Sticky Information Model of Households’ Inflation Expectations
2009
This paper provides a simple epidemiology model where households, when forming their inflation expectations, rationally adopt the past release of inflation with certain probability rather than the forward-looking newspaper forecast as suggested in Carroll [2003, Macroeconomic Expectations of Households and Professional Forecasters, Quarterly Journal of Economics, 118, 269-298]. The posterior model probabilities based on the Michigan survey data strongly support the proposed model. We also extend the agent-based epidemiology model by deriving for it a simple adaptation, which is suitable for estimation. Our results show that this model is able to capture the heterogeneity in households’ expe…