Search results for "Simulation"
showing 10 items of 5095 documents
Modeling and Simulation as a Pedagogical and Heuristic Tool for Developing Theories in Cognitive Science: An Example from Ritual Competence Theory
2019
An interdisciplinary team of researchers in the fields of philosophy, religious studies, cognitive science, and computer science aimed to develop a computer model of ritual behaviour, based on McCauley and Lawson’s theory of ritual competence. That endeavour revealed some questions about the internal consistency and significance of the theory that had not previously been noticed or addressed. It also demonstrated how modeling and simulation can serve as valuable pedagogical and heuristic tools for better specifying theories that deal with complex social phenomena.
A Full-Scale Agent-Based Model to Hypothetically Explore the Impact of Lockdown, Social Distancing, and Vaccination During the COVID-19 Pandemic in L…
2021
Background The COVID-19 outbreak, an event of global concern, has provided scientists the opportunity to use mathematical modeling to run simulations and test theories about the pandemic. Objective The aim of this study was to propose a full-scale individual-based model of the COVID-19 outbreak in Lombardy, Italy, to test various scenarios pertaining to the pandemic and achieve novel performance metrics. Methods The model was designed to simulate all 10 million inhabitants of Lombardy person by person via a simple agent-based approach using a commercial computer. In order to obtain performance data, a collision detection model was developed to enable cluster nodes in small cells that can b…
A Theoretical Agent-Based Model to simulate an Artificial Social Evolution
2013
Agent-based social simulation as a computational approach to social simulation has been largely used to explore social phenomena. The purpose of this paper is to build a theoretical agent-based model to simulate the social evolution of a set of agents/artificial societies. In this model, each agent (artificial society) has an available number of social behaviours that compete among each other. The agent/agent interactions are carried out by their social otherwise, the agent/environment interactions are expressed through the consumption of ecological resources in repression and satisfaction by social behaviours of the agent. In this work, we will present the structure and the formulation of …
An agent-based model to support the preliminary design and operation of heating and power grids with cogeneration units and photovoltaic panels in de…
2022
The increase in the energy demands of residential neighborhoods constitutes a huge challenge to be faced. A viable option lies in the insertion of both renewable energy production systems and cogeneration units within urban territories. On-site production allows for the satisfaction of the heating and electrical demands of end-users and favors the distribution of produced energy within the neighborhood, especially under the regulatory framework of energy communities. This paper proposes a tool to model heating and electricity networks integrated with cogeneration units and PV panels installed in urban areas. The tool accounts for the following possibilities: (i) energy flow management and p…
Semantically enriched informed environment for multi-agent simulation : application to simulation in 3D virtual environment
2014
This thesis focuses on multi-agent simulation applied to the simulation of individuals in virtual 3D buildings. To do this, our work suggests to capitalize on the experience gained in the field of semantic web ontologies and inference engines to facilitate the design and development of intelligent behavior for agents operating in virtual worlds. The goal is to provide to agents a generic approach to managing their representation of the world and reason about this representation. For this, the central problem is based on the definition of a decidable ontology modeling all of the knowledge contained in the virtual 3D environment to enrich semantically the environment of a multi-agent simulati…
A simplified framework to optimize MRI contrast preparation
2018
PURPOSE This article proposes a rigorous optimal control framework for the design of preparation schemes that optimize MRI contrast based on relaxation time differences. METHODS Compared to previous optimal contrast preparation schemes, a drastic reduction of the optimization parameter number is performed. The preparation scheme is defined as a combination of several block pulses whose flip angles, phase terms and inter-pulse delays are optimized to control the magnetization evolution. RESULTS The proposed approach reduces the computation time of B 0 -robust preparation schemes to around a minute (whereas several hours were required with previous schemes), with negligible performance loss. …
Integrated care pathways for airway diseases (AIRWAYS-ICPs)
2014
International audience; The objective of Integrated Care Pathways for Airway Diseases (AIRWAYS-ICPs) is to launch a collaboration to develop multi-sectoral care pathways for chronic respiratory diseases in European countries and regions. AIRWAYS-ICPs has strategic relevance to the European Union Health Strategy and will add value to existing public health knowledge by: 1) proposing a common framework of care pathways for chronic respiratory diseases, which will facilitate comparability and trans-national initiatives; 2) informing cost-effective policy development, strengthening in particular those on smoking and environmental exposure; 3) aiding risk stratification in chronic disease patien…
Exploring kainate receptor pharmacology using molecular dynamics simulations.
2010
Ionotropic glutamate receptors (iGluRs) are enticing targets for pharmaceutical research; however, the search for selective ligands is a laborious experimental process. Here we introduce a purely computational procedure as an approach to evaluate ligand–iGluR pharmacology. The ligands are docked into the closed ligand-binding domain and during the molecular dynamics (MD) simulation the bi-lobed interface either opens (partial agonist/antagonist) or stays closed (agonist) according to the properties of the ligand. The procedure is tested with closely related set of analogs of the marine toxin dysiherbaine bound to GluK1 kainate receptor. The modeling is set against the abundant binding data …
Structural Mechanism of N-Methyl-D-Aspartate Receptor Type 1 Partial Agonism
2012
N-methyl-D-aspartate (NMDA) receptors belong to a family of ionotropic glutamate receptors that contribute to the signal transmission in the central nervous system. NMDA receptors are heterotetramers that usually consist of two GluN1 and GluN2 monomers. The extracellular ligand-binding domain (LBD) of a monomer is comprised of discontinuous segments that form the functional domains D1 and D2. While the binding of a full agonist glycine to LBD of GluN1 is linked to cleft closure and subsequent ion-channel opening, partial agonists are known to activate the receptor only sub-maximally. Although the crystal structures of the LBD of related GluA2 receptor explain the mechanism for the partial a…
Trait Empathy associated with Agreeableness and rhythmic entrainment in a spontaneous movement to music task: Preliminary exploratory investigations
2017
The simulation theory of empathy suggests that we use motor processing to empathise, through modelling the actions of others. Similarly, research into embodied music cognition posits that music, particularly musical rhythm, is perceived as a motor stimulus. In both cases, the human Mirror Neuron System (MNS) is put forward as a potential underlying mechanism. If this is the case, some overlap may exist between the ability to empathise with others, and the ability to perceive rhythm in music. The present study investigated this relationship indirectly, through the study of individual differences in Trait Empathy and rhythmic entrainment. Undergraduate students ( N = 237) completed a questio…