Search results for "Small"
showing 10 items of 2441 documents
: Difficulties ans risks of interSME cooperation : solutions provided by private-equity firms
2016
L’article analyse les difficultés et risques auxquels font face les petites et moyennes entreprises (PME) lors de la formation de coopérations interfirmes, et les rôles joués par les sociétés de capital-investissement dans leur diminution. Les PME font principalement face à une asymétrie informationnelle et une incertitude accrues en comparaison aux entreprises plus grandes. Les sociétés de capital-investissement permettent de réduire ces deux facteurs et d’instaurer une situation de confiance entre les futurs cocontractants, ce qui évite l’échec de la transaction. Une étude de cas multiples à visée infirmationniste menée sur le marché français du capital-investissement détaille ces princip…
Reflections on conspicuous sustainability: Creating Small Island Dependent States (SIDS) through Ostentatious Development Assistance (ODA)?
2020
Abstract It is frequently noted that small islands, including Small Island Developing States (SIDS), receive hugely disproportionate levels of aid or official development assistance (ODA) relative to other states and territories. However, the precise relationship between 'islandness' and aid remains underexamined. This paper uses the concept of 'conspicuous sustainability' as a framework for understanding the propensity for aid to be directed toward small island territories. We argue (1) that aid donors have reasons for preferring engagement in development projects that are particularly conspicuous, irrespective of actual development outcomes and (2) that small island territories are except…
Maternal Affection Moderates the Associations Between Parenting Stress and Early Adolescents’ Externalizing and Internalizing Behavior
2019
The present study investigated the role of parenting stress in early adolescents’ externalizing and internalizing behavior and, particularly, the moderating effect of maternal affection on these associations. The data of 992 early adolescents ([Formula: see text]; 454 girls) and their mothers during the transition from primary school to lower secondary school were analyzed. The results showed that when maternal affection was low, parenting stress was not related to the changes in early adolescents’ externalizing or internalizing behavior. In contrast, when maternal affection was high, low parenting stress related to a decrease and high parenting stress to an increase in such behavior. The …
Small solar system bodies as granular systems
2017
Asteroids and other Small Solar System Bodies (SSSBs) are currently of great scientific and even industrial interest. Asteroids exist as the permanent record of the formation of the Solar System and therefore hold many clues to its understanding as a whole, as well as insights into the formation of planetary bodies. Additionally, SSSBs are being investigated in the context of impact risks for the Earth, space situational awareness and their possible industrial exploitation (asteroid mining). In all these aspects, the knowledge of the geophysical characteristics of SSSB surface and internal structure are of great importance. Given their size, constitution, and the evidence that many SSSBs ar…
Density of States characterization of TiO2 films deposited by Pulsed Laser Deposition for Heterojunction solar cells
2021
The application of titanium dioxide (TiO2) in the photovoltaic field is gaining traction as this material can be deployed in doping-free heterojunction solar cells with the role of electron selective contact. For modeling-based optimization of such contact, knowledge of the titanium oxide defect density of states is crucial. In this paper, we report a method to extract the defect density through nondestructive optical measures, including the contribution given by small polaron optical transitions. The presence of both related to oxygen-vacancy defects and polarons is supported by the results of optical characterizations and the evaluation of previous observations resulting in a defect band …
Fine-Tuning of the film thickness of ultrathin multilayer films composed of consecutively alternating layers of anionic and cationic polyelectrolytes
2007
We have recently introduced a new method of creating ultrathin films [1–3] based on the electrostatic attraction between opposite charges. Consecutively, alternating adsorption of anionic and cationic polyelectrolytes leads to the formation of multilayer assemblies. Multilayer buildup is easily monitored by small angle x-ray scattering (SAXS). The total thickness of the multilayer assemblies increases linearly with the number of adsorbed layers, indicating a stepwise and regular deposition process. — Here, we report on the fine-tuning of the total film thickness by changing the ionic strength of the solvent from which the polyelectrolytes are adsorbed. When the anionic polyelectrolyte is ad…
Transdermal and Skin-Targeted Drug Delivery
1997
Background: The application of therapeutic agents to the skin addresses three general objectives: (a) the treatment of a variety of dermatologic diseases; (b) the “targeted” delivery of drugs to deeper subcutaneous tissues, with a concomitant reduction in systemic exposure; and (c) socalled transdermal administration to elicit a systemic pharmacologic effect. Objective: Recently, significant progress towards all three goals has been recorded and the level of research and development activity remains high. We aim to discuss these advances from mechanistic and clinical standpoints. Results: For the topical treatment of skin disease, novel vehicles (e.g., stabilized, supersaturated systems and…
BIBF 1120/ nintedanib : a new triple angiokinase inhibitor-directed therapy in patients with non-small cell lung cancer.
2013
Abstract: Introduction: Several new targeted agents with anti-angiogenic properties have been developed recently, including vandetanib, sunitinib, sorafenib, bevacizumab and others. Tumor development, progression, metastasis are strongly linked to angiogenesis. Targeted agents like bevacizumab, a monoclonal antibody which targets VEGF, have been fully developed in several solid tumors. These new agents strongly advocate that targeting angiogenesis is one of the best approaches for cancer therapy. Areas covered: Those agents that target additional pro-angiogenic intracellular signaling pathways beyond VEGF signaling have also the potential to contribute to anticancer therapies. The authors p…
Psoriatic arthritis and COVID ‐19 pandemic: Consequences in medical treatment?
2020
The COVID‐19 pandemic has a strong negative impact on human society world‐wide. Patients with immune‐mediated disease may be prone to an increased risk of infection and/ or more severe course. We review the available data for patients with psoriatic arthritis (PSA) and systemic treatments. Current treatment options are summarized. Based upon the experience with COVID‐19 the following problems are addressed: (a) Can systemic treatment reduce comorbidities of PsA that are also comorbidities for COVID‐19? Does systemic medical treatment pose an increased risk of infection with SARS‐CoV‐2? Does systemic drug therapy have an impact on the risk of pulmonary fibrosis ‐ a factor with strong negativ…
Identification of Three-Way DNA Junction Ligands through Screening of Chemical Libraries and Validation by Complementary in Vitro Assays
2019
International audience; The human genome is replete with repetitive DNA sequences that can fold into thermodynamically stable secondary structures such as hairpins and quadruplexes. Cellular enzymes exist to cope with these structures whose stable accumulation would result in DNA damage through interference with DNA transactions such as transcription and replication. Therefore, the chemical stabilization of secondary DNA structures offers an attractive way to foster DNA transaction-associated damages to trigger cell death in proliferating cancer cells. While much emphasis has been recently given to DNA quadruplexes, we focused here on three-way DNA junctions (TWJ) and report on a strategy t…