Search results for "Small"

Direct transfer of vitrified rabbit embryos.

1994

In this study we looked at the feasibility of transferring vitrified rabbit embryos directly into recipient does. Compacted morulae were vitrified in a solution of 20% ethylene glycol and 20% dimethyl sulfoxide. After thawing, and without step-wise diluted solution, the vitrified embryos were transferred into the recipient's uterine horns. Survival rate at birth differed from fresh rabbit embryos (40% vs 55%, P0.05). However, the percentage of does that delivered (94%) and the survival rate suggested this method is suitable for both storage and simple transfer of rabbit morulae.

La Sicilia dei centri minori: Above the clouds nella Valle di Bolognetta : architettura, arti performative e nuovi immaginari

2021

Il lavoro elaborato dal Gruppo di ricerca LabCity Architecture sulla rigenerazione dei piccoli centri rurali del territorio siciliano, vittime della crisi economica e demografica di quest’ultimo decennio, evidenzia l’urgenza di un ripensamento delle strategie di intervento in questi luoghi con forti potenzialità territoriali, patrimoniali e culturali, proponendo progetti di ricerca-azione in sinergia con le comunità locali coinvolte. La recente emergenza sanitaria causata dalla pandemia da Covid-19 ha evidenziato l’esigenza di una ricerca mirata ad individuare i caratteri e le esigenze specifiche soprattutto dei centri minori, destinatari di politiche e di interventi spesso inadeguati. In q…

Optimal sample allocation conditioned on a small area model, estimator, and auxiliary data

2018

We have studied optimal sample allocation, associated with small area estimation, when the objective is to obtain as accurate estimates as possible, for the population and for the subpopulations, called as areas here. It is a question of a two-level optimization problem. The basic premise is composed of planned areas, stratified sampling, and small overall sample size predetermined by restricted time and budget resources. Low sample sizes are common in market surveys. During this thesis, we have developed new allocation methods, based on a small area model, estimator, and auxiliary data. The final method, the three-term Pareto allocation, is based on the three terms of the mean-squared erro…

Additional benefits of beclomethasone/formoterol extrafine combination treatment on small airways function in asthma

2009

Looking for the best immune-checkpoint inhibitor in pre-treated NSCLC patients: An indirect comparison between nivolumab, pembrolizumab and atezolizu…

2017

Immune-checkpoint inhibitors represent the new standard of care in patients with advanced NSCLC who progressed after first-line treatment. This work aim to assess any difference in both efficacy and safety profiles among Nivolumab, Pembrolizumab and Atezolizumab in pre-treated NSCLC patients. Randomized clinical trials comparing immune-checkpoint inhibitor versus docetaxel in pre-treated patients with advanced NSCLC were included and direct comparison meta-analysis of selected trials have been performed. Subsequently the summary estimates of Nivolumab, Pembrolizumab and Atezolizumab emerging from the direct meta-analysis were selected to provide the pooled estimates of hazard ratio (HR) and…

Low prevalence of the atherogenic small, dense LDL in a mediterranean population. Nutrition, Metabolism and Cardiovascular Diseases

2002

Developing narrative identities in youth pre-elite sport : bridging the present and the future

2019

Narrative research has contributed to understandings of athletic identity as an evolving story of the self that is creatively put together by the agentic individual but necessarily dependent on broader narratives within which we all live our lives. However, most studies in sport have focused on retrospective ‘big stories’ of athletes’ lives, rather than on-going, future-oriented identity construction through storytelling. In this study, we explored Finnish pre-elite athletes’ emerging stories of the self to understand the processes associated with the narrative selection and the resources they tap into in making sport meaningful to them. Nine women and eight men aged 17–18 were invited to c…

Focus on the Small GTPase Rab1: A Key Player in the Pathogenesis of Parkinson’s Disease

2021

Parkinson’s disease (PD) is the second most frequent neurodegenerative disease. It is characterized by the loss of dopaminergic neurons in the substantia nigra and the formation of large aggregates in the survival neurons called Lewy bodies, which mainly contain α-synuclein (α-syn). The cause of cell death is not known but could be due to mitochondrial dysfunction, protein homeostasis failure, and alterations in the secretory/endolysosomal/autophagic pathways. Survival nigral neurons overexpress the small GTPase Rab1. This protein is considered a housekeeping Rab that is necessary to support the secretory pathway, the maintenance of the Golgi complex structure, and the regulation of macroau…

Novel Insights into the Cellular Localization and Regulation of the Autophagosomal Proteins LC3A, LC3B and LC3C

2020

Macroautophagy is a conserved degradative process for maintaining cellular homeostasis and plays a key role in aging and various human disorders. The microtubule-associated protein 1A/1B light chain 3B (MAP1LC3B or LC3B) is commonly analyzed as a key marker for autophagosomes and as a proxy for autophagic flux. Three paralogues of the LC3 gene exist in humans: LC3A, LC3B and LC3C. The molecular function, regulation and cellular localization of LC3A and LC3C have not been investigated frequently, even if a similar function to that described for LC3B appears likely. Here, we have selectively decapacitated LC3B by three separate strategies in primary human fibroblasts and analyzed the evoked e…

Distinct bhaplotype structure at the innate immune receptor Toll-like receptor 2 across bank vole populations and lineages in Europe

2015

Abstract: Parasite-mediated selection may contribute to the maintenance of genetic variation at host immune genes over long time scales. To date, the best evidence for the long-term maintenance of immunogenetic variation in natural populations comes from studies on the major histocompatibility complex (MHC) genes, whereas evidence for such processes from other immune genes remains scarce. In the present study, we show that, despite pronounced population differentiation and the occurrence of numerous private alleles within populations, the innate immune gene Toll-like receptor 2 (TLR2) displays a distinct haplotype structure in 21 bank vole (Myodes glareolus) populations across Europe. Haplo…