Search results for "Small"
showing 10 items of 2441 documents
"Incidence of different KRAS mutation in non-small cell lung cancer (NSCLC) patients, TAILOR STUDY
2011
Drug-Coated Balloon vs. Stent for de novo Non-small Coronary Artery Disease: A Systematic Review and Meta-Analysis
2021
Introduction: Drug-coated balloon (DCB) has been an attractive option in de novo vessels. A systematic review and meta-analysis were conducted to evaluate the efficacy and safety of DCB vs. stent for treating de novo lesions in non-small vessels.Methods: Studies in PubMed, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science were searched (from their commencement to March 2021). This meta-analysis was performed by Review Manager 5.3.Results: A total of 3 random controlled trials (RCTs) with 255 patients and 2 observational studies (OS) with 265 patients were included in this meta-analysis following our inclusion criteria. It could be observed that DCB presented no …
Four essays on IT users' psychological states and behaviors
2016
This dissertation is intended to study information technology (IT) users’ psychological states and behaviors. It consists of four essays. The first essay examines how people react to social networking services (SNS). In this essay, we attempted to extend the existing model, which includes dedication- and constraint-based mechanisms, by additionally including the obligation-based mechanism underlying SNS-related behavior. The second essay is designed to investigate individuals’ smartphone use. In particular, we focused on the role of smartphone addiction in shaping individuals’ perceptions about their smartphone. The third essay is about online community behavior. Drawing on the model of eng…
Problem Talk in Management Group Meetings
2019
This naturalistic study focuses on problem talk (PT) in hospital management group meetings. The study aims to understand how PT constitutes the hospital organization through the different uses of PT within the meetings, and, therefore, to understand the organizing role of these meetings. The communication as constitutive of organization (CCO) perspective forms the theoretical background of the research. The results of the qualitative analysis show that PT comprises many intertwined tasks that aim to perform the meetings, enhance problem solving, and maintain the relational level of group life. Thus, PT is much more than merely solving problems. In PT, problems are discussed from the viewpo…
Lipoprotein Subfractions in Metabolic Syndrome and Obesity: Clinical Significance and Therapeutic Approaches
2013
Small, dense low density lipoprotein (sdLDL) represents an emerging cardiovascular risk factor, since these particles can be associated with cardiovascular disease (CVD) independently of established risk factors, including plasma lipids. Obese subjects frequently have atherogenic dyslipidaemia, including elevated sdLDL levels, in addition to elevated triglycerides (TG), very low density lipoprotein (VLDL) and apolipoprotein-B, as well as decreased high density lipoprotein cholesterol (HDL-C) levels. Obesity-related co-morbidities, such as metabolic syndrome (MetS) are also characterized by dyslipidaemia. Therefore, agents that favourably modulate LDL subclasses may be of clinical value in t…
Suunnittelumallien hyödyntäminen tietoturvallisessa ohjelmistokehityksessä
2017
Tietoturvasta on viime aikoina tullut entistäkin tärkeämpi osa-alue ohjelmistokehityksessä. Tietoturvan merkityksen kasvaessa tarvitaan menetelmiä, joilla tietoturva voidaan huomioida koko ohjelmistokehitysprosessin ajan. Suunnittelumallien käyttämistä on esitetty erääksi keinoksi ohjelmistojen tietoturvan parantamisessa. Tässä tutkielmassa tarkastellaan, kuinka suunnittelumalleja käyttämällä voidaan vaikuttaa ohjelmistojen tietoturvaan. Information security has become an essential part of software development. As the importance of information security grows, it is essential to find methods for taking information security into account during software development processes. Design patterns h…
The role of SAXS and molecular simulations in 3D structure elucidation of a DNA aptamer against lung cancer
2021
Aptamers are short, single-stranded DNA or RNA oligonucleotide molecules that function as synthetic analogs of antibodies and bind to a target molecule with high specificity. Aptamer affinity entirely depends on its tertiary structure and charge distribution. Therefore, length and structure optimization are essential for increasing aptamer specificity and affinity. Here, we present a general optimization procedure for finding the most populated atomistic structures of DNA aptamers. Based on the existed aptamer LC-18 for lung adenocarcinoma, a new truncated LC-18 (LC-18t) aptamer LC-18t was developed. A three-dimensional (3D) shape of LC-18t was reported based on small-angle X-ray scattering…
International activities of knowledge-intensive small- and medium-sized enterprises: The example of an open source software firm
2009
Purpose: The purpose of this paper is to develop a framework that explains international activities of open source software (OSS) firms. Design/methodology/approach: This paper reviews relevant literature related to international operations of knowledge-intensive firms, especially in the software industry. Theoretical development is based here on a combination of the network approach, international new venture theory and inward–outward internationalization. Findings: The findings in this study suggest that the international activities of OSS firms can be divided into project activities and business activities. Project activities include inward and outward linkages, and partner identificatio…
A person-oriented approach to maternal homework involvement during the transition to lower secondary school
2022
This study examined patterns of mothers' homework involvement (n = 680 in Grade 6 and 665 in Grade 7) and changes in them during 12-year-old Finnish adolescents' (n = 848; 391 boys) transition to lower secondary school. Moreover, the extent to which adolescents' motivational behavior and prior academic achievement predicted these patterns was examined. The latent transition analyses identified four relatively stable latent patterns of maternal homework involvement in Grades 6 and 7: averagely involved, psychologically controlling and intrusive, noninvolved, and intrusive monitoring and helping. The higher task avoidance and the poorer achievement adolescents showed, the more likely their mo…