Search results for "Small"

ePortfolio-ohjaus Centria ammattikorkeakoulussa

2013

Ohjaus Vehkalahden koulussa

2012

Hankkeeni tavoitteena on laatia koulumme ohjaussuunnitelmalle runkoa ja tehdä valmistelevaa työtä ohjaussuunnitelmaa varten. Tämä työ ei siis ole varsinainen ohjaussuunnitelma. Tässä työssä kartoitetaan ja kirjataan ylös kaikki ohjaustoiminta mitä Vehkalahden koulussa toteutetaan eri toimijoiden taholta tällä hetkellä. Hankkeen tarkoitus on avata mahdollisimman selkeästi näkyville tämän hetkinen tilanne kokonaisuudessaan ja selvittää toiminnan kehittämistarpeet. Sen pohjalta koulussamme voidaan myöhemmin jatkaa ohjaussuunnitelman laadintaa ja täydentää näin opetussuunnitelmaa siihen kuuluvalla ohjaussuunnitelmalla. Olen aloittanut työni vertailemalla erilaisia ohjaussuunnitelmia ja tutkimal…

Pair interactions in online assessments of collaborative problem solving: case-based portraits

2018

This exploratory case study focuses on how pairs of students can build a shared understanding and acquire collaborative problem-solving (CPS) practices during an online assessment of CPS skills, which is seen in the context of the CPS construct, in a symmetrical and asymmetrical task type. Even though CPS is widely recognised as a core twenty-first-century competency, its nature is not yet well understood. Also, until recently, most of studies have focused on the individual’s solution to a problem or on the skills individuals bring into a problem-solving space. This study extends from an individual- to group-level focus in CPS, emphasising the role and quality of the social aspects in CPS p…

Vuorovaikutus hallinnollisissa ryhmissä

2020

This article aims to analyze international research on social interaction in administrative groups in the 2000s on the basis of a systematic examination of 62 peer-reviewed empirical research reports. We examined the data through a qualitative content analysis and organized the results into three sections: 1) defining an administrative group, 2) the used research methods and data, and 3) the focus of research. Our results showed that administrative groups were mainly defined on the basis of the employed research approach and data. Group conceptualizations were seldom based on specific theoretical group definitions or approaches. In the context of research methods, there were no specific tre…

Pulsating B and Be stars in the Small Magellanic Cloud

2008

Context: Stellar pulsations in main-sequence B-type stars are driven by the kappa-mechanism due to the Fe-group opacity bump. The current models do not predict the presence of instability strips in the B spectral domain at very low metallicities. As the metallicity of the SMC is lower than Z=0.005, it constitutes a very suitable object to test these predictions. Aims: The main objective is to investigate the existence of B-type pulsators at low metallicities, searching for short-term periodic variability in absorption-line B and Be stars in the SMC. The analysis has been performed in a sample of 313 B and Be stars with fundamental astrophysical parameters accurately determined from high-res…

Should we measure routinely oxidized and small dense low-density lipoproteins in subjects with type 2 diabetes

2010

Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma

2017

Given the paucity of druggable mutations in high-risk neuroblastoma (NB), we undertook chromatin-focused small interfering RNA and chemical screens to uncover epigenetic regulators critical for the differentiation block in high-risk NB. High-content Opera imaging identified 53 genes whose loss of expression led to a decrease in NB cell proliferation and 16 also induced differentiation. From these, the secondary chemical screen identified SETD8, the H4K20me1 methyltransferase, as a druggable NB target. Functional studies revealed that SETD8 ablation rescued the pro-apoptotic and cell-cycle arrest functions of p53 by decreasing p53K382me1, leading to activation of the p53 canonical pathway. I…

Apollon gene silencing induces apoptosis in breast cancer cells via p53 stabilisation and caspase-3 activation

2009

We analysed the effects of small interfering RNA (siRNA)-mediated silencing of Apollon, a member of the inhibitors of apoptosis protein family, on the proliferative potential and ability of human breast cancer cell lines to undergo apoptosis. In wild-type p53 ZR75.1 cells, Apollon knockdown resulted in a marked, time-dependent decline of cell growth and an increased rate of apoptosis, which was associated with p53 stabilisation and activation of the mitochondrial-dependent apoptotic pathway. Pre-incubation of cells with a p53-specific siRNA resulted in a partial rescue of cell growth inhibition, as well as in a marked reduction of the apoptotic response, indicating p53 as a major player in …

Targeting HSP90 with the small molecule inhibitor AUY922 (luminespib) as a treatment strategy against hepatocellular carcinoma

2018

Hepatocellular carcinoma (HCC) is a highly malignant tumor that responds very poorly to existing therapies, most probably due to its extraordinary inter- and intra-tumor molecular heterogeneity. The modest therapeutic response to molecular targeted agents underlines the need for new therapeutic approaches for HCC. In our study, we took advantage of well-characterized human HCC cell lines, differing in transcriptomic subtypes, DNA mutation and amplification alterations, reflecting the heterogeneity of primary HCCs, to provide a preclinical evaluation of the specific heat shock protein 90 (HSP90) inhibitor AUY922 (luminespib). Indeed, HSP90 is highly expressed in different tumor types, but it…

Plausible Role of Estrogens in Pathogenesis, Progression and Therapy of Lung Cancer

2021

Malignant neoplasms are among the most common diseases and are responsible for the majority of deaths in the developed world. In contrast to men, available data show a clear upward trend in the incidence of lung cancer in women, making it almost as prevalent as breast cancer. Women might be more susceptible to the carcinogenic effect of tobacco smoke than men. Furthermore, available data indicate a much more frequent mutation of the tumor suppressor gene-p53 in non-small cell lung cancer (NSCLC) female patients compared to males. Another important factor, however, might lie in the female sex hormones, whose mitogenic or carcinogenic effect is well known. Epidemiologic data show a correlatio…