Search results for "Smok"
showing 10 items of 769 documents
Cigarette smoke promotes inflammasome‐independent activation of caspase‐1 and ‐4 leading to gasdermin D cleavage in human macrophages
2022
Mechanisms and consequences of gasdermin D (GSDMD) activation in cigarette smoke (CS)-associated inflammation and lung disease are unknown. GSDMD is a downstream effector of caspase-1, -8, and -4. Upon cleavage, GSDMD generates pores into cell membranes. Different degrees of GSDMD activation are associated with a range of physiological outputs ranging from cell hyperactivation to pyroptosis. We have previously reported that in human monocyte-derived macrophages CS extract (CSE) inhibits the NLRP3 inflammasome and shifts the response to lipopolysaccharide (LPS) towards the TLR4-TRIF axis leading to activation of caspase-8, which, in turn, activates caspase-1. In the present work, we investig…
Cellular and Molecular Signatures of Oxidative Stress in Bronchial Epithelial Cell Models Injured by Cigarette Smoke Extract
2022
Exposure of the airways epithelium to environmental insults, including cigarette smoke, results in increased oxidative stress due to unbalance between oxidants and antioxidants in favor of oxidants. Oxidative stress is a feature of inflammation and promotes the progression of chronic lung diseases, including Chronic Obstructive Pulmonary Disease (COPD). Increased oxidative stress leads to exhaustion of antioxidant defenses, alterations in autophagy/mitophagy and cell survival regulatory mechanisms, thus promoting cell senescence. All these events are amplified by the increase of inflammation driven by oxidative stress. Several models of bronchial epithelial cells are used to study the molec…
Certain advantages of Scopus compare with Web of Science in a bibliometric analysis related to smoking
2013
El objetivo de este trabajo es comparar entre Web of Science (WoS) y Scopus los indicadores bibliométricos básicos del área de tabaquismo de autores españoles en el período 2000-2009. Métodos: La búsqueda se realizó en el SCI-Expanded y Scopus (“smok*” OR “tobac*”). Resultados: La media total anual del nº de documentos fue de 41 ± 12 para WoS vs 60 ± 16 en Scopus (p = 0,007). Aumento progresivo del índice de colaboración. La media anual del índice de colaboración fue de 9,41 ± 2,73 en WoS vs 7,12 ± 1,52 en Scopus (p = 0,029). Mayor número de citas con el paso del tiempo en ambas bases de datos pero son más recientes las citas en Scopus, el índice citas/artículo fue mayor en WoS (WoS 14,47 v…
COVID-19 Y SU REPERCUSIÓN EN LAS ADICCIONES
2021
espanolObjetivo. Indagar acerca de la literatura cientifica emergente a nivel internacional sobre la repercusion de la pandemia por COVID-19 en las adicciones. Metodologia. La base de datos Web of Science se utilizo para analizar la literatura cientifica sobre la pandemia por COVID-19 y la influencia que esta pueda tener en el ambito de las adicciones. Resultados. Se identificaron 320 documentos, de los cuales 38 cumplieron los criterios de inclusion. Sobresalieron tres problematicas: el consumo de tabaco, opioides y alcohol. Segun la literatura incipiente, entre los consumidores de opiaceos existe el riesgo de aumento de las sobredosis, asi como un empeoramiento del binomio estres-alcohol …
Scientific Literature Among Smoking and Respiratory System: Repercussion and Collaboration
2012
a b s t r a c t Aim: To analyze the distribution of the production, repercussion and co-authorship of articles on smok- ing in the "respiratory system" category through the Science Citation Index Expanded (SCI-E) and their inclusion in the first quartile of the Journal Citation Report (JCR). Methods: The literature search was performed in the SCI-E. Articles were selected for 2001-2010 for "respiratory system" using the descriptors "smok*" and "tobac*". Results: We found 1858 articles (ignoring collaboration) on the topic of smoking. The median number of published articles by five-year period was higher for the 2006-2010 period vs the 2001-2005 period; in contrast, the number of citations a…
Cigarette smoke affects the onco-suppressor DAB2IP expression in bronchial epithelial cells of COPD patients
2019
AbstractCigarette smoke is a risk factor for COPD and lung cancer. In cancer, epigenetic modifications affect the expression of Enhancer of Zester Homolog 2 (EZH2), and silenced disabled homolog 2 interacting protein gene (DAB2IP) (onco-suppressor gene) by Histone H3 tri-methylation in lysine 27 (H3K27me3). In“ex vivo”studies, we assessed EZH2, H3K27me3 and DAB2IP immunoreactivity in bronchial epithelial cells from COPD patients (smokers, ex-smokers), Smoker and control subjects. In“in vitro” experiments we studied the effect of cigarette smoke extract (CSE) on EZH2/H3K27me3/DAB2IP expression, apoptosis, invasiveness, and vimentin expression in 16HBE, primary cells, and lung cancer cell lin…
Using an extended version of the theory of planned behaviour to predict smoking cessation in two age groups
2011
The aim of this study was twofold: (i) to test the utility of the theory of planned behaviour (TPB) in predicting intentions to quit smoking and subsequent behaviour in two age groups, and among women and men, and (ii) to examine whether descriptive norms, moral norms and past behaviour predict intentions and behaviour beyond the impact of the TPB components. Analyses were based on data from a prospective sample of 447 daily smokers (adolescents 16–19 years, n = 174, M = 17.5, adults 35–55 years, n = 311, M = 44 years). The TPB accounted for 31.8% and 38% of the variance in intentions in the adolescent and adult groups, respectively. The extension variables added 12.6% and 12.1% to the …
An extended version of the theory of planned behavour: Prediction of intentions to quit smoking using past behaviour as moderator
2010
It was hypothesised that: (i) intentions to quit smoking were predictable from group identity, self-identity, moral norms and past quit attempts, beyond the components of the Theory of Planned Behaviour (TPB), and (ii) that past experiences with the behaviour (quit attempts) would increase the predictive utility of the extended TPB model on intentions. The data was collected among 357 daily smoking students (M = 24 years). The TPB components accounted for 12.3% of the variance in quitting intentions, while the extension variables added 16.5% to the explained variance in intentions beyond the impact of the TPB. Past behaviour had the strongest impact on intentions (α = 0.30), followed by mor…
Cigarette smoke increases BLT2 receptor functions in bronchial epithelial cells: in vitro and ex vivo evidence
2013
Summary Leukotriene B4 (LTB4) is a neutrophil chemotactic molecule with important involvement in the inflammatory responses of chronic obstructive pulmonary disease (COPD). Airway epithelium is emerging as a regulator of innate immune responses to a variety of insults including cigarette smoke, the major risk factor for COPD. In this study we have explored whether cigarette smoke extracts (CSE) or soluble mediators present in distal lung fluid samples (mini-bronchoalveolar lavages) from smokers alter the expression of the LTB4 receptor 2 (BLT2) and peroxisome proliferator-activated receptor-α (PPAR-α) in bronchial epithelial cells. We also evaluated the effects of CSE on the expression of i…
Exposure to cigarette smoke extract and lipopolysaccharide modifies cytoskeleton organization in bronchial epithelial cells
2017
The integrity of the respiratory epithelium is crucial for airway homeostasis. Tobacco smoke exposure and recurrent infections of the airways play a crucial role in the progression and in the decline of the respiratory function in chronic obstructive pulmonary disease (COPD). The aim of this study was to detect differentially expressed proteins in a bronchial epithelial cell line (16-HBE) stimulated with cigarette smoke extract (CSE) and lipopolysaccharide (LPS), a constituent of gram-negative bacteria, alone and/or in combination, by using two-dimensional electrophoresis (2DE) analysis coupled with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Western blot a…