Search results for "Smoking"
showing 10 items of 641 documents
Biomonitoring in wearers of permethrin impregnated battle dress uniforms in Afghanistan and Germany.
2013
Objectives To analyse differences in uptake of the insecticide permethrin in wearers of non-impregnated and permethrin impregnated battle dress uniforms (BDU) in Afghanistan and Germany. Methods In two separate studies, in April 2003–January 2004 (study I, n=549) and in February–April 2005 (study II, n=195), healthy female and male members of the German Federal Armed Forces were equipped with permethrin impregnated BDU (two sub-cohorts in Germany and one in Afghanistan) while members equipped with non-impregnated uniforms served as a control group. Human biomonitoring was conducted before, during and after wearing the uniforms by measuring permethrin metabolites in urine samples via GC–MS. …
Lifetime cumulative risk factors predict cardiovascular disease mortality in a 50-year follow-up study in Finland.
2015
Summary. Background. Systolic blood pressure, total cholesterol and smoking are known predictors of cardiovascular disease (CVD) mortality. Less is known about the effect of lifetime accumulation and changes of risk factors over time as predictors of CVD mortality, especially in very long follow-up studies. Methods. Data from the Finnish cohorts of the Seven Countries Study were used. The baseline examination was in 1959 and seven re-examinations were carried out approximately in five-year intervals. Cohorts were followed up for mortality until the end of 2011. Time-dependent Cox models with regular time-updated risk factors, time-dependent averages of risk factors and latest changes in ris…
Long-time expression of DNA repair enzymes MGMT and APE in human peripheral blood mononuclear cells.
2001
The DNA repair enzymes O6-methylguanine-DNA methyltransferase (MGMT) and apurinic/apyrimidinic endonuclease (APE, also known as Ref-1) play an important role in cellular defense against the mutagenic and carcinogenic effects of DNA-damaging agents. Cells with low enzyme activity are more sensitive to induced DNA damage and may confer a higher carcinogenic risk to the individuals in question. To study the level of variability of MGMT and APE expression in human, we analyzed in a long-time study MGMT and APE expression in peripheral blood mononuclear cells (PBMC) from healthy individuals. The data revealed high inter- and intraindividual variability of MGMT but not of APE. For MGMT, the inter…
Drinking, smoking, and educational achievement: Cross-lagged associations from adolescence to adulthood
2014
Background Adolescent substance use is associated with lower educational achievement but the directionality of the association remains uncertain. We analyzed data on drinking, smoking and educational achievement to study the associations between substance use and education from early adolescence to young adulthood. Methods Longitudinal data from four time points (ages 12, 14, 17, and 19–27 years) from a population-based cohort study of Finnish twin individuals were used to estimate bivariate cross-lagged path models for substance use and educational achievement, adjusting for sex, parental covariates, and adolescent externalizing behavior. A total of 4761 individuals (49.4% females) were in…
Nicotine effects on anterior cingulate cortex in schizophrenia and healthy smokers as revealed by EEG-informed fMRI
2012
Abstract Nicotine can have beneficial effects on attention performance and corresponding brain function in both schizophrenia patients and healthy controls, but it remains controversial whether nicotine affects brain function differentially in patients vs. controls. The effects of nicotine on brain activity elicited by attention-requiring oddball-type tasks have not been studied in schizophrenia patients. In this study we sought to investigate the impact of nicotine on the p300 evoked potential component and corresponding fMRI (functional magnetic resonance imaging) activation measures in schizophrenia patients and controls. Applying a double-blind, placebo-controlled cross-over design, the…
Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2 ) with nicotine addiction
2009
Genetic factors contribute to the overall risk of developing nicotine addiction, which is the major cause of preventable deaths in western countries. However, knowledge regarding specific polymorphisms influencing smoking phenotypes remains scarce. In the present study we provide evidence that a common single nucleotide polymorphism (SNP) in the 5′ untranslated region of CHRM2, the gene coding for the muscarinic acetylcholine receptor 2 is associated with nicotine addiction. CHRM2 was defined as a candidate gene for nicotine addiction based on previous evidence that linked variations in CHRM2 to alcohol and drug dependence. A total of more than 5,500 subjects representative of the German po…
Differences in psychomotor reaction time in male monozygotic twins discordant for lifetime cigarette smoking.
1996
The effects of long-term cigarette smoking on psychomotor reaction time were investigated among 8 pairs of monozygotic male twins highly discordant for lifetime smoking (means 32.4 versus 0.6 pack-years). The men had no diagnosed cardiovascular disease or other major diseases, musculoskeletal complaints, or vision problems that might interfere with reaction time testing. The twins had similar education, work, and exercise histories; alcohol and coffee consumption and exposure to solvents were examined as possible confounds. Direct comparison of cotwins also controlled for age, genetics, and possible early environmental factors. Simple and choice reaction time were measured in the dominant h…
Long-term effects of nicotine gum on weight gain after smoking cessation.
1999
Smoking cessation usually results in weight gain. Nicotine gum therapy has been found to reduce weight gain in the first months after cessation, but its long-term effects are not fully known. The present study randomly assigned 608 smokers to receive placebo, 2 or 4 mg nicotine gum. In a follow-up analysis to the short-term weight change results reported in a previous paper [Doherty, Militello, Kinnunen, & Garvey (1996), Journal of Consulting and Clinical Psychology 64:799-807], we examined the effects of the nicotine gum on weight change for 1 year after cessation among the 92 1-year abstainers. We found that weight change showed some variation with gum dose (active vs. placebo), but that …
Schizophrenic patients who smoke have a faster finger tapping rate than non-smokers
2002
The increased rate of smoking in schizophrenia patients remains unexplained and may reflect attempts at self-treatment. The effect sought from smoking may be related to nicotine's stimulating action. We tested this hypothesis by examining the relationship between smoking status and finger tapping rate, a measure of central processing, in schizophrenia patients treated with atypical antipsychotics. Smokers showed significantly faster finger tapping rates than non-smokers. This was not related to clinical state, illness chronicity, medication side-effects, antipsychotic dose or plasma concentrations. Nicotine can improve central processing in medicated schizophrenia patients and this may cons…
Parental monitoring moderates the importance of genetic and environmental influences on adolescent smoking.
2007
Although there is a substantial literature on the role of parenting in adolescent substance use, most parenting effects have been small in magnitude and studied outside the context of genetically informative designs, raising debate and controversy about the influence that parents have on their children (D. C. Rowe, 1994). Using a genetically informative twin-family design, the authors studied the role of parental monitoring on adolescent smoking at age 14. Although monitoring had only small main effects, consistent with the literature, there were dramatic moderation effects associated with parental monitoring: At high levels of parental monitoring, environmental influences were predominant …