Search results for "Smooth"

Effects of different agents on the contractile response elicited by extracellular calcium after depletion of internal calcium stores in rat isolated …

1993

Abstract Noradrenaline, 1 μm, induced a sustained contractile response in rat isolated aorta in the presence and in the absence of extracellular Ca2+. After depleting the noradrenaline-sensitive intracellular Ca2+ stores, an increase in the basal tone of the aorta was observed during the incubation period in the presence of Ca2+ and in the absence of the agonist. We have tested the possible pathways through which Ca2+ enters the cell to refill the previously depleted Ca2+ pools, a process that is accompanied by an increase in tension. The magnitude of this increase does not depend on the presence of Mg2+ in the extracellular medium nor on the temperature, suggesting that it is mediated by a…

On the Bullwhip Avoidance Phase: supply chain collaboration and order smoothing

2009

This paper provides an assessment of the impact of collaboration and smoothing replenishment rules on supply chain operational performance and customer service level. Three supply chain configurations (i.e. Traditional, Information Exchange and Synchronised) in which orders are generated by smoothing (S, R) inventory control policies are studied for different proportional controllers. A supply chain stress test is performed through a sudden and intense change in demand. A structured and extended supply chain assessment framework is adopted. The main conclusions of this paper are the following. (i) The impact of Supply Chain Collaboration on overall supply chain performance is greater than t…

Inventory policies and information sharing in multi-echelon supply chains

2011

The aim of this article is to show how to modify a replenishment rule in relation to the operational information shared by suppliers. More specifically, we present a model of an Automatic Pipeline Variable Inventory and Order-Based Production Control System rule for a multi-echelon supply chain characterised by different increasing levels of shared information. A numerical study is presented to underline the performance differences for three variants of the smoothing order rule in terms of bullwhip reduction, inventory stability and operational and customer responsiveness. Results show how the effectiveness of a smoothing replenishment rule depends on the level of information sharing.

The smoothed particle hydrodynamics method via residual iteration

2019

Abstract In this paper we propose for the first time an iterative approach of the Smoothed Particle Hydrodynamics (SPH) method. The method is widespread in many areas of science and engineering and despite its extensive application it suffers from several drawbacks due to inaccurate approximation at boundaries and at irregular interior regions. The presented iterative process improves the accuracy of the standard method by updating the initial estimates iterating on the residuals. It is appealing preserving the matrix-free nature of the method and avoiding to modify the kernel function . Moreover the process refines the SPH estimates and it is not affected by disordered data distribution. W…

Induced smoothing in LASSO regression

The thesis is being carried out with the National research Council at the Institute of Biomedicine and Molecular Immunology "Alberto Monroy" of Palermo, where I am a fellow, under the supervision of MD Stefania La Grutta. Our research unit is focused on clinical research in allergic respiratory problems in children. In particular, we are interested in to assess the determinants of impaired lung function in a sample of outpatient asthmatic children aged between 5 and 17 years enrolled from 2011 to 2017. Our dataset is composed by n = 529 children and several covariates regarding host and environmental factors. This thesis focuses on hypothesis testing in lasso regression, when one is interes…

Numerical investigation of rain droplet impact on offshore wind turbine blades under different rainfall conditions: A parametric study

2020

The leading edge of a fiber composite wind turbine blade (WTB) is prone to erosion damages due to repeated rain droplet impact during its service life. Such damages are critical to the blade's aerodynamic as well as structural performance, ultimately resulting in substantial repair costs. An effective design of a coating material for WTB is necessary and its analysis must include variables associated with erosive rain droplets such as (1) droplet diameter, (2) impact velocity, and (3) droplet impact angle. The present paper develops and validates a coupled fluid structure interaction (FSI) computational model for simulating rain droplet impact on WTBs, where the structure domain is modelled…

Immunoexpression of p53 in cutaneous and subcutaneous leiomyosarcomas.

2016

The diagnosis of malignancy in cutaneous and subcutaneous smooth muscle tumors is based on subtle criteria. Therefore, any ancillary technique useful in this differential diagnosis is always welcome. In this report, we study the immunoexpression of p53 in 19 malignant smooth muscle tumors of the skin (15 cutaneous leiomyosarcomas, 2 subcutaneous leiomyosarcomas, and 2 cutaneous metastases of leiomyosarcoma), as well as in 1 leiomyoma with cellular atypia, therefore complementing a previous study on p53 immunoexpression in leiomyomas of the skin. The p53 staining was positive in 12 (63.16%) of 19 leiomyosarcomas. Percentages of immunostaining in the positive cases varied from 2% to 95%. Ten …

In regard to “A tale of two clones: Caldesmon staining in the differentiation of cutaneous spindle-cell neoplasms”

2018

Bounded Palais–Smale sequences for non-differentiable functions

2011

The existence of bounded Palais-Smale sequences (briefly BPS) for functionals depending on a parameter belonging to a real interval and which are the sum of a locally Lipschitz continuous term and of a convex, proper, lower semicontinuous function, is obtained when the parameter runs in a full measure subset of the given interval. Specifically, for this class of non-smooth functions, we obtain BPS related to mountain pass and to global infima levels. This is done by developing a unifying approach, which applies to both cases and relies on a suitable deformation lemma. © 2011 Elsevier Ltd. All rights reserved.

Castration and Erection

1988

Castrated dogs (n = 3) need a much higher threshold level of energy to induce erection by electrical stimulation of the cavernous nerve than noncastrated animals (n = 24). In addition the resulting quality of erection, measured as maximal intracavernous pressure (pCC) versus peak systolic blood pressure (BP), was weaker in castrated dogs (pCC = 57% of BP on average) than in noncastrated dogs (pCC = 80% of BP on average). A high venous outflow from the corpora cavernosa in castrated dogs can also explain the shorter duration of erection. This experimental model excludes the interference of subjective factors, such as erotic stimuli and libido on erection, and it seems that androgen deficienc…