Search results for "SoMe"
showing 10 items of 5114 documents
INDUCTION OF CYTOCHROME P-448 BY 3-METHYLCHOLANTHRENE IN THE RAT DURING INHIBITION OF PROTEIN SYNTHESIS IN VIVO
1977
Administration of cycloheximide in vivo during induction of rats with 3-methylcholanthrene prevents the increase in total cytochrome P-450 content usually seen under the influence of the inducer. The population of cytochromes P-450 in the livers of these animals is, however, similar to that in the completely induced animals. Microsomal aryl hydrocarbon hydroxylase activity and biphenyl-2-hydroxylation are enhanced severalfold and biphenyl-4-hydroxylation is enhanced twofold. Monooxygenase activity shows the same pattern of preferential inhibition as in microsomes from animals which had received the inducer only. The affinity of the reduced cytochromes for the ligand metyrapone is considerab…
Effect of Antioxidants on Microsomal Enzymes of Rat Liver
1978
Rat diet was supplemented with butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA) or ethoxyquin (EQ) for 14 days, and hepatic microsomal epoxide hydratase (EH) and monooxygenase were subsequently studied in vitro. The antioxidants increased EH activity. The increase was marked with BHT (factor 3) and EQ (factor 4) and was paralleled by an increase in a protein band on SDS polyacrylamide gels which migrated together with purified rat hepatic EH. A slight but nonsignificant increase in cytochrome P450 content and a moderate increase in ethoxycoumarin deethylation and cytochrome b5 content was also observed while aryl hydrocarbon hydroxylase (AHH) activity was not elevated. Irrever…
Chromosome analysis using different staining techniques and fluorescent in situ hybridization in Cerithium vulgatum (Gastropoda: Cerithiidae)
2002
In the present paper one population of the “large” subtidal mollusc Cerithium vulgatum Bruguiere, 1792 (Gastropoda: Cerithiidae) from the Northwestern coast of Sicily was investigated from a karyological point of view. The chromosome complement was Giemsa stained, conventionally karyotyped in 18 homomorphic chromosome pairs (10 bi-armed and 8 mono-armed), and subsequently analysed using silver, CMA3 and DAPI staining, and fluorescent in situ hybridization (FISH) with three repetitive DNA probes [ribosomal DNA (rDNA), (TTAGGG)n and (GATA)n]. FISH with the rDNA probe consistently mapped major ribosomal sites (18S-28S rDNA) in the terminal region of the short arms of one small sized mono-armed…
On the role of the triplet state in the cis/trans isomerization of rhodopsin: A CASPT2//CASSCF study of a model chromophore
2011
The possibility of population of the lowest-lying triplet state (T1) in the early events of the photochemical isomerization process of a model chromophore of Rhodopsin (Rh) has been analyzed using multireference perturbation theory (CASPT2//CASSCF) methods. It is shown that the characteristics of the isomerization process namely small S1−T1 gap, presence of hydrogen out of plane active vibrational modes, and existence of a dense manifold of vibrational states, render possible the fulfilment of the conditions needed for the population of T1. The possible consequences for the photochemistry and photophysics of Rh are also discussed. © 2011 Wiley Periodicals, Inc. Int J Quantum Chem 111:3431–3…
Maximal isometric muscle strength and functional ability in daily activities among 75-year-old men and women
2007
The purpose of this study was to analyze whether functional ability in daily activities among 75-year-old men and women is predicted by physical activity, isometric muscle strength and simple function tests. In this representative sample of a general population of 405 75-year-olds, isometric muscle strength and functional ability in daily activities were closely related (odds ratio of disability 1.2–2.1), stressing the importance of strength in the truncus, proximal and distal muscle groups for daily activities. There were strong correlations between physical activity, isometric muscle strength as well as simple function tests and ability to manage daily activities. Those with even light ph…
Association Study of Genetic Variants in the 14q11 - 14q13 Proteasomal Genes Cluster with Juvenile Idiopathic Arthritis (JIA) in Latvian Population
2009
Association Study of Genetic Variants in the 14q11 - 14q13 Proteasomal Genes Cluster with Juvenile Idiopathic Arthritis (JIA) in Latvian Population The possible role of proteasomes in the development of autoimmune diseases was hypothesised after discovery of the involvement of proteasomal LMP2 and LMP7 subunits in antigene processing. The objective of this study was to determine the association between allelic variants of the genes encoding proteasomal proteins PSME1, PSME2 and PSMA6 and juvenile idiopathic arthritis (JIA) in the Latvian population. One Indel G-4543 CA-4544 →GA and four SNPs related to the PSMA6 gene (A-2486 →G and C-1910 →T, upstream promoter, C-110 →A of promoter, and C-8…
Comparison of the roles of common constitutional and behavioural parameters in back performance estimates
2006
Objective: To compare the associations between different physical activity histories and anthropometric measures in isokinetic lifting performance, isometric back extension endurance and psychophysical lifting tests. Background: The relative roles and interaction of these factors related to back function are largely unknown. Methods: The subjects consisted of a population-based sample of 210 working-age males. Paraspinal muscle cross-sectional areas were obtained by magnetic resonance imaging; anthropometric measures, isokinetic and psychophysical lifting capacity, and isometric back extension endurance tests were performed and current and physical activity histories and occupational loadin…
Isospin symmetry in $B(E2)$ values: Coulomb excitation study of ${}^{21}$Mg
2018
The $T_z$~=~$-\frac{3}{2}$ nucleus ${}^{21}$Mg has been studied by Coulomb excitation on ${}^{196}$Pt and ${}^{110}$Pd targets. A 205.6(1)-keV $\gamma$-ray transition resulting from the Coulomb excitation of the $\frac{5}{2}^+$ ground state to the first excited $\frac{1}{2}^+$ state in ${}^{21}$Mg was observed for the first time. Coulomb excitation cross-section measurements with both targets and a measurement of the half-life of the $\frac{1}{2}^+$ state yield an adopted value of $B(E2;\frac{5}{2}^+\rightarrow\frac{1}{2}^+)$~=~13.3(4)~W.u. A new excited state at 1672(1)~keV with tentative $\frac{9}{2}^+$ assignment was also identified in ${}^{21}$Mg. This work demonstrates large difference…
β Decay of 127Cd and Excited States in 127In
2019
A dedicated spectroscopic study of the β decay of 127Cd was conducted at the IGISOL facility at the University of Jyväskylä. Following high-resolution mass separation in a Penning trap, β−γ−γcoincidences were used to considerably extend the decay scheme of 127In. The β-decaying 3/2+ and 11/2− states in 127Cd have been identified with the 127Cd ground state and the 283-keV isomer. Their respective half-lives have been measured to 0.45(128)s and 0.36(4) s. The experimentally observed βfeeding to excited states of 127In and the decay scheme of 127In are discussed in conjunction with large-scale shell-model calculations. peerReviewed
Decay of a 19− isomeric state in 156Lu
2018
A multiparticle spin-trap isomeric state having a half-life of 179(4) ns and lying 2601 keV above the yrast 10 + state in 156 Lu has been discovered. The 156 Lu nuclei were produced by bombarding isotopically enriched 106 Cd targets with beams of 58 Ni ions, separated in flight using the gas-filled separator RITU and their decays were measured using the GREAT spectrometer. Analysis of the main decay path that populates yrast states observed previously suggests a spin-parity assignment of 19 − for the isomeric state, which is consistent with isomeric states identified in the N = 85 isotones. Comparison with other decay paths in 156 Lu indicates that the [ π h − 1 11 / 2 ⊗ ν h 9 / 2 ] 10 + st…