Search results for "SoMe"
showing 10 items of 5114 documents
Regulation of the Transferrin Receptor Recycling in Hepatitis C Virus-Replicating Cells
2020
After binding of its ligand transferrin, the transferrin receptor (TfR) is internalized via early endosomes. Ligand and receptor can be recycled. α-Taxilin was identified as an essential factor for TfR recycling. Apart from its role for iron uptake, TfR is a coreceptor for hepatitis C virus (HCV) infection. In HCV-replicating cells, the amount of a-taxilin is decreased. This study aims to investigate the effect of decreased α-taxilin levels in HCV-replicating cells on recycling of TfR, its amount on the cell surface, on iron uptake, and the impact of a disturbed TfR recycling on HCV superinfection exclusion. TfR amount and localization were determined by CLSM and surface biotinylation. α-ta…
Induction of apoptosis by the proteasome inhibitor MG132 in human HCC cells: Possible correlation with specific caspase-dependent cleavage of β-caten…
2004
Proteasome inhibitors, like MG132, can exert cell growth inhibitory and apoptotic effects in different tumor types. The apoptotic mechanism of these compounds involves the activation of the effector caspases. beta-catenin, also an oncogene, represents one of the substrates of these proteases, but the consequences of its cleavage are poorly understood. We investigated its function during apoptosis induced by MG132 in three hepatocellular carcinoma (HCC) cell lines, endowed (HepG2 and HuH-6) or not (HA22T/VGH) with activating mutations of beta-catenin. Induction of apoptosis was associated with cell growth inhibition, accumulation of the cells at the G(2)/M phases of the cell cycle, as well a…
Organocatalytic approach to benzofused nitrogen-containing heterocycles: enantioselective total synthesis of (+)-angustureine.
2008
Maternal-fetal cross-talk: elucidating the role of mir-30d in endometrial receptivity and pregnancy outcome
2018
Introducción En el proceso de implantación embrionaria se produce una relación sincrónica entre el endometrio y el embrión que resulta fundamental para su correcta consecución; dicha sincronía se mantiene durante la gestación gracias a la existencia de una comunicación bidireccional entre la madre y el feto basada en la secreción de señales específicas que permiten regular un desarrollo cooperativo. Efectivamente, se ha observado como el embrión libera moléculas específicas del estado gestacional (ej.: gonadotropina coriónica humana o interferón tau en rumiantes), para prevenir la luteólisis inducida por la prostaglandina F2alpha, posibilitando la secreción continua de progesterona durante …
Chiral gamma-lactones from Fusarium poae: enentiomeric ratios and sensory differentiation of cis-6-gamma-dodecenolactone enantiomers
1991
Chiral gamma-lactones from Fusarium poae: enentiomeric ratios and sensory differentiation of cis-6-gamma-dodecenolactone enantiomers
WILLIAMS-BEUREN MAPPING IN CALLITHRIX ARGENTATA, CALLICEBUS CUPREUS AND ALOUATTA CARAYA INDICATES DIFFERENT PATTERNS OF CHROMOSOMAL REARRANGEMENTS IN…
2007
Human chromosome 7 has a complex syntenic origin. It was divided into two segments in both the ancestral primate karyotype and in Platyrrhini. Apparently, a small segment in the ancestral platyrrhine karyotype was associated with HSA5 and the remainder formed a middle-sized submetacentric. We tested the dynamics of platyrrhine chromosomes by hybridizing the locus specific Willams-Beuren probe (7q 11.23, 450 kb) to chromosomes of representative species from the three families of the New World monkeys recently proposed by molecular genomics: Cebidae, Callithrix argentata (bare ear marmoset or silvery marmoset, 2n = 44); Pitheciidae, Callicebus cupreus [red titi monkey, or coppery monkey, 2n =…
Vesiclepedia:A Compendium for Extracellular Vesicles with Continuous Community Annotation
2012
Vesiclepedia is a community-annotated compendium of molecular data on extracellular vesicles.
Molecular Cytogenetics as a Tool for Primate Taxonomic identification: A Case Study in Captivity
2015
caratteristiche peculiari essendo notturne e monogame. Hanno un’ampia distribuzione geografica che si estende dallo stretto di Panama al nord dell’Argentina; questo determina una notevole complessità nella distribuzione e di conseguenza nell’interpretazione sistematica e filogenetica. Lo studio del genere Aotus mediante l’analisi di caratte ri morfologici e genetici ha prodotto una tassonomia controversa. Inizialmente era riconosciuta solo la specie Aotus trivirgatus, successivamente in base alla colorazione del pelo del collo, alla diversa suscettibilità alla malaria e ai dati citogenetici sono state identificate fino a nove specie, oltre a due sibling species, per un totale di 11.1,2 Il n…
The Boulton-Katritzky Reaction: A Kinetic Study of the Effect of 5-Nitrogen Substituents on the Rearrangement of Some (Z)-phenylhydrazones of 3-Benzo…
2014
The kinetics of the ring-into-ring conversion of some new (Z)-phenylhydrazones of 3-benzoyl-1,2,4-oxadiazole containing different nitrogen-substituents at C-5 (3b-d; X = NHMe, NMe2, and NHCOMe) into the relevant triazoles 4b-d have been examined in a wide range of pS+ (0.1-11.9) in 1:1 (v/v) dioxane/water solution. The obtained results have been compared with previous data concerning the (Z)-phenyl-hydrazone of 5-amino-3-benzoyl-1,2,4-oxadiazole (3a; X = NH2). All of the studied (Z)-phenylhydrazones rearrange through three different pathways (specific acid-catalysed, uncatalysed and general base-catalysed). The different effects of the substituents on the course of the rearrangement in the …
Hypertrofisen kuormituksen akuutit vaikutukset lihastonukseen
2008
Mälkiä, Sampo. 2008. Hypertrofisen kuormituksen akuutit vaikutukset lihastonukseen. Valmennus- ja testausopin kandidaatintutkielma. Jyväskylän yliopisto. Liikuntabiologian laitos. 46 sivua. Aikaisemmat lihastonukseen liittyvät tutkimukset ovat keskittyneet kliinisiin tutkimuksiin eri potilasryhmillä. Tämän tutkimuksen tarkoituksena oli selvittää tapahtuuko lihastonuksessa muutosta raskaan hypertrofisen kuormituksen seurauksena. Tutkimukseen osallistui 24 miespuolista koehenkilöä (ikä 26.0 ± 4.3 v, pituus 181.3 ± 6.4 cm, paino 78.4 ± 8.0 kg). Koehenkilöt jaettiin satunnaisesti kahteen ryhmään siten, että toinen ryhmistä (n=15) suoritti hypertrofisen kuormituksen, toisen (n=9) toimiessa kontr…