Search results for "Sobp"
showing 4 items of 4 documents
The Proton-Boron Reaction Increases the Radiobiological Effectiveness of Clinical Low- and High-Energy Proton Beams: Novel Experimental Evidence and …
2021
Protontherapy is a rapidly expanding radiotherapy modality where accelerated proton beams are used to precisely deliver the dose to the tumor target but is generally considered ineffective against radioresistant tumors. Proton-Boron Capture Therapy (PBCT) is a novel approach aimed at enhancing proton biological effectiveness. PBCT exploits a nuclear fusion reaction between low-energy protons and 11B atoms, i.e. p+11B→ 3α (p-B), which is supposed to produce highly-DNA damaging α-particles exclusively across the tumor-conformed Spread-Out Bragg Peak (SOBP), without harming healthy tissues in the beam entrance channel. To confirm previous work on PBCT, here we report new in-vitro data obtained…
DOSIMETRIA ESR CON ALANINA PER ADRONTERAPIA CON IONI CARBONIO
2015
La sicurezza del paziente sottoposto a trattamenti terapeutici con radiazioni ionizzanti e il buon esito degli ultimi sono strettamente legati all’ottimizzazione delle procedure di esposizione alle radiazioni ionizzanti. In particolare è fondamentale arrecare il danno minore possibile ai tessuti sani che circondano la neoplasia da trattare. Rispetto ai campi di radiazione convenzionali utilizzati in radioterapia (fotoni), le particelle cariche pesanti (protoni e ioni carbonio) offrono diversi vantaggi quali la bassa dispersione laterale, l’alta efficacia biologica (RBE) nella regione del picco di Bragg ed un profilo di dose caratteristico in profondità del tutto differente da quello dei fot…
Alanine EPR pellets for dosimetry of clinical proton and carbon ion beams
2015
The main gol of the present work is to investigate the response behaviour of alanine EPR pellets in clinical proton anc carbon ion beams. Proton irradiations were carried out at PSI (Switzerland) using both passive and active scattering modality, whereas, C ions irradiation were performed at GSI (Germany) adopting the raster scanning modality.
EPR/alanine dosimetry for two therapeutic proton beams
2016
Abstract In this work the analysis of the electron paramagnetic resonance (EPR) response of alanine pellets exposed to two different clinical proton beams employed for radiotherapy is performed. One beam is characterized by a passive delivery technique and is dedicated to the eyes treatment (OPTIS2 beam line). Alanine pellets were irradiated with a 70 MeV proton beam corresponding to 35 mm range in eye tissue. We investigated how collimators with different sizes and shape used to conform the dose to the planned target volume influence the delivered dose. For this purpose we performed measurements with varying the collimator size (Output Factor) and the results were compared with those obtai…