Search results for "Soin"
showing 10 items of 600 documents
Sex-allocation conflict and sexual selection throughout the lifespan of eusocial colonies.
2018
AbstractModels of sex allocation conflict are central to evolutionary biology but have mostly assumed static decisions, where resource allocation strategies are constant over colony lifespan. Here, we develop a model to study how the evolution of dynamic resource allocation strategies is affected by the queen-worker conflict in annual eusocial insects. We demonstrate that the time of dispersal of sexuals affects the sex allocation ratio through sexual selection on males. Furthermore, our model provides three predictions that depart from established results of classic static allocation models. First, we find that the queen wins the sex allocation conflict, while the workers determine the max…
Fifteen operationally important decisions in the planning of biodiversity offsets
2018
Many development projects, whether they are about construction of factories, mines, roads, railways, new suburbs, shopping malls, or even individual houses, have negative environmental consequences. Biodiversity offsetting is about compensating that damage, typically via habitat restoration, land management, or by establishment of new protected areas. Offsets are the fourth step of the so-called mitigation hierarchy, in which ecological damage is first avoided, minimized second, and third restored locally. Whatever residual damage remains is then offset. Offsetting has been increasingly adopted all around the world, but simultaneously serious concerns are expressed about the validity of the…
Precision, Applicability, and Economic Implications: A Comparison of Alternative Biodiversity Offset Indexes
2021
AbstractThe rates of ecosystem degradation and biodiversity loss are alarming and current conservation efforts are not sufficient to stop them. The need for new tools is urgent. One approach is biodiversity offsetting: a developer causing habitat degradation provides an improvement in biodiversity so that the lost ecological value is compensated for. Accurate and ecologically meaningful measurement of losses and estimation of gains are essential in reaching the no net loss goal or any other desired outcome of biodiversity offsetting. The chosen calculation method strongly influences biodiversity outcomes. We compare a multiplicative method, which is based on a habitat condition index develo…
An experimental heat wave changes immune defense and life history traits in a freshwater snail
2013
The predicted increase in frequency and severity of heat waves due to climate change is expected to alter disease dynamics by reducing hosts' ability to resist infections. This could take place via two different mechanisms: (1) through general reduction in hosts' performance under harsh environmental conditions and/or (2) through altered resource allocation that reduces expression of defense traits in order to maintain other traits. We tested these alternative hypotheses by measuring the effect of an experimental heat wave (25 vs. 15°C) on the constitutive level of immune defense (hemocyte concentration, phenoloxidase [PO]‐like activity, antibacterial activity of hemolymph), and life histor…
Peer-to-peer cooperative GNSS-based localization for stationary reference nodes in wireless sensor networks
2017
Most localization algorithms in wireless sensor networks rely on a few reference nodes with known locations to estimate the locations of unknown nodes. The locations of reference nodes can be either manually configured or, more practically, obtained by means of some satellite-based positioning system(s). However, satellite-based locations may be inaccurate and imprecise, which results in reduced location accuracy of localization algorithms. This paper proposes a peer-to-peer cooperative GNSS-based localization algorithm for stationary reference nodes to improve their relative location accuracy and precision. The algorithm applies simple statistical methods and GNSS-based information from mu…
Investigation of Isoindolo[2,1-a] quinoxaline-6-imines as Topoisomerase I Inhibitors with Molecular Modeling Methods
2017
Background: Isoindolo[2,1-alpha] quinoxalines constitute an important class of compounds which demonstrated potent antiproliferative activity against different human tumor cell lines and topoisomerase I inhibitors. In particular, their water soluble imine or iminium salts recently synthesized showed potent growth inhibitory effect on NCI-60 tumor cell line panel and biological studies performed on the most active compounds demonstrated that they cause DNA damage via topoisomerase I poisoning. Objective: Herein, we investigate with molecular modeling methods, the common features responsible for topoisomerase I inhibition of the water-soluble isoindolo[2,1-alpha] quinoxalin-6-imines, by compa…
Making sense of big data in health research: {T}owards an {EU} action plan
2016
Genome medicine 8(1), 71 (2016). doi:10.1186/s13073-016-0323-y
[1,2]Oxazolo[5,4-e]isoindoles as promising tubulin polymerization inhibitors
2016
Abstract A series of [1,2]Oxazolo [5,4- e ]isoindoles has been synthesized through a versatile and high yielding sequence. All the new structures showed in the 1 HNMR spectra, the typical signal in the 8.34–8.47 ppm attributable to the H-3 of the [1,2]oxazole moiety. Among all derivatives, methoxy benzyl substituents at positions 3 and 4 or/and 5 were very effective in reducing the growth of different tumor cell lines, including diffuse malignant peritoneal mesothelioma (DMPM), an uncommon and rapidly malignancy poorly responsive to available therapeutic options. The most active compound 6j was found to impair tubulin polymerization, cause cell cycle arrest at G2/M phase and induce apoptosi…
Le bien-être alimentaire du quotidien à l’institution hospitalière : de nouveaux enjeux normatifs.
2020
Cet article interroge la façon dont les questions sanitaires jouent sur les normes en matière de santé. Dans une perspective diachronique et culturellement située, l’objectif de l’article sera, dans un premier temps, de montrer que le bien-être est une valeur évolutive aux prismes des attentes sociétales. D’un bien-être aux contours fermés et délimités, les enjeux sociaux et la forte médiatisation de la nutrition en font une valeur qui évolue, dont la qualification reste toujours difficile à saisir. Dans un second temps, l’article propose la construction d’un outil de mesure du bien-être alimentaire en contexte hospitalier afin d’intégrer des éléments subjectifs et actuels autour des attent…
Containers in Software Development: A Systematic Mapping Study
2019
Over the past decade, continuous software development has become a common place in the field of software engineering. Containers like Docker are a lightweight solution that developers can use to deploy and manage applications. Containers are used to build both component-based architectures and microservice architectures. Still, practitioners often view containers only as way to lower resource requirements compared to virtual machines. In this paper, we conducted a systematic mapping study to find information on what is known of how containers are used in software development. 56 primary studies were selected into this paper and they were categorized and mapped to identify the gaps in the cu…