Search results for "Solid"

Towards a fully synthetic MUC1-based anticancer vaccine: efficient conjugation of glycopeptides with mono-, di-, and tetravalent lipopeptides using c…

2011

Abstract The membrane-bound tumor-associated glycoprotein MUC1 is aberrantly glycosylated in cancer cells compared with normal cells, and is therefore considered an attractive target for cancer immunotherapy. However, tumor-associated glycopeptides from MUC1 do not elicit a sufficiently robust immune response. Therefore, antitumor vaccines were developed, which consist of MUC1 glycopeptides as the B epitopes and immune-stimulating toll-like receptor 2 (TLR 2) lipopeptide ligands. These fully synthetic vaccine candidates were prepared by solid-phase synthesis of the MUC1 glycopeptides. The Pam(3) Cys lipopeptide, also synthesized on solid-phase, was C-terminally coupled to oligovalent lysine…

ACID-BASE INTERACTIONS AND THEIR ROLE IN FORECASTING OF POLYMER COMPOSITES ADHESION PROPERTIES

2010

Acid-base properties of wide range of polymers and adhesion systems based on polymers, polymer composites and metals were investigated. Composite materials based on high and low density polyethylenes, ethylene copolymers, other carbochain and heterochain polymers, synthetic rubber and their based on composites, epoxy composites, cured with a wide range of curing agents were used as adhesives. By using the contact angle of test liquids the values of the dispersion, acid-base, acid and base components of the surface free energy were calculated and the acidity parameter was estimated by means of van Oss-Chaudhury-Good and E. Berger methods respectively. Effect of composition on acidity and bas…

ULTRA-BROADBAND COHERENT DETECTION OF TERAHERTZ PULSES VIA CMOS-COMPATIBLE SOLID-STATE DEVICES

Il presente lavoro di tesi presenta e dimostra una tecnica innovativa e completamente integrata dedita alla rilevazione coerente di radiazioni a frequenze Terahertz (THz), cioè di onde elettromagnetiche il cui contenuto frequenziale cade convenzionalmente nella finestra spettrale compresa tra 0.1-10x1012 Hz. Tale tecnica è stata battezzata col nome di solid-state-biased coherent detection (SSBCD), dal momento che essa sfrutta le proprietà di un mezzo a stato solido e consente di ricostruire simultaneamente l’informazione sulla fase e sull’ampiezza degli impulsi THz, anche nel caso in cui quest’ultimi siano dotati di spettri a banda cosiddetta “ultra larga” (> 10 THz). Tale metodo di rivelaz…

Vegetation of solid rock faces and fissures of the alpine and subnival zone in the Pamir Alai Mountains (Tajikistan, Middle Asia)

2014

The paper presents results of phytosociological researches on rock faces vegetation of Pamir Alai Mountains. In total, 182 phytosociological relevés were made during the field studies conducted in 2006–2012, applaying the Braun-Blanquet method. Plant communities of calcareous firm rock faces and small fissures, inhabiting mainly the alpine and subnival zone in several ranges (e.g. Zeravshan Mts, Hissar Mts, Hazratishoh Mts, Darvaz Mts, Rushan Mts and Vanch Mts) are herein described for the first time. A hierarchical syntaxonomic synopsis of the rock communities of the Pamir Alai is provided. The collected vegetation samples represent the majority of the variability among the phytocoenoses o…

Combined use of liquid chromatography triple quadrupole mass spectrometry and liquid chromatography quadrupole time-of-flight mass spectrometry in sy…

2012

As a suitable way for routine screening of pesticides and control of other organic contaminants in water, the combination of liquid chromatography triple quadrupole tandem mass spectrometry (LC-QqQ-MS/MS) and liquid chromatography-hybrid quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) has been applied to the analysis of 63 surface and waste water samples after conventional solid-phase extraction (SPE). The extracts were screened for 43 pesticides or degradation products by LC-QqQ-MS/MS achieving limits of detection (LOD) ranged from 0.04 to 2 ng L(-1). Of the 43 selected pesticides, 33 were detected in water samples. The ESI-QTOF MS instrument was run using two simultaneous acquisi…

Initial Preparation and Characterization of Single Step Fabricated Intermediate Temperature Solid Oxide Fuel Cells (IT-SOFC)

2013

In this study, facile tape casting process has been successfully carried out to fabricate an unit anode supported intermediate temperature solid oxide fuel cell (IT-SOFC) with four different layers: a composite cathode which is a mix of La0.6Sr0.4Co0.2Fe0.8O3 (LSCF48) and Gd0.1Ce0.9O1.9 (GDC10), GDC10 as thin electrolyte layer, NiO-GDC10 without pore former as thin anode functional layer (AFL), and anode support layer of NiO-GDC10 with carbon pore former. The multi-layer was sintered once to produce an unit planar cell. An OCV of 1.002 V at 500 °C, and maximum power density of 466 mW cm–2 at 648 °C are obtained. These results indicate negligible leakage of fuel through electrolyte. Furtherm…

THERAPEUTIC-LOADED LIPID NANOSTRUCTURES AND BRAIN DISEASES.

2012

Central Nervous System (CNS) diseases represent the largest and fastest growing area of unmet medical need since an alarming increase in brain disease incidence is going on. Despite major advances in neuroscience, many potential therapeutic agents are denied access to the CNS because of the existence of a physiological low permeable barrier, the Blood-Brain Barrier (BBB). To obtain an improvement of drug CNS performance, sophisticated approaches such as nanoparticulate systems are rapidly developing. In particular, in this chapter, the most recent data demonstrating the potential of lipid nanostructures, such as Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC), to tra…

Les fusions de sociétés : régimes juridique et fiscal

2012

National audience; ...

A New Methodological Approach to Correlate Protective and Microscopic Properties by Soft X-ray Microscopy and Solid State NMR Spectroscopy: The Case …

2021

Hydrophobic treatment is one of the most important interventions usually carried out for the conservation of stone artefacts and monuments. The study here reported aims to answer a general question about how two polymers confer different protective performance. Two fluorinated-based polymer formulates applied on samples of Cusa’s stone confer a different level of water repellence and water vapour permeability. The observed protection action is here explained on the basis of chemico-physical interactions. The distribution of the polymer in the pore network was investigated using scanning electron microscopy and X-ray microscopy. The interactions between the stone substrate and the protective…

The infrared thermography control of the laser welding of amorphous polymers

2008

In laser welding technique, a real-time control of temperature distribution inside the irradiated materials is essential when attempting to optimize the process. For all laser welding methods that operate by the transmission principle, the difficulty of recording the developed temperature at the interface derives from the fact that materials to be welded are in contact throughout the entire process. In the present study, in order to overcome this issue, a contact-free method such the infrared thermography is used for surface temperature measurement. Corroborating this data with a numerical simulation of the temperature field evolution inside the components, an assessment of optimal process …