Search results for "Somites"

showing 3 items of 3 documents

Female pelvic congenital malformations. Part I: embryology, anatomy and surgical treatment.

2011

This review covers the most important female congenital pelvic malformations. The first part focuses on the embryological development of the urogenital and anorectal apparatus, morphological features, and the diagnostic and surgical approach to abnormalities. Comprehension of the embryological development of the urogenital and anorectal apparatus is essential to understand the morphology of congenital pelvic abnormalities and their surgical treatment. Congenital pelvic malformations are characterized by specific common features; the severity of which often subverts the pelvic morphology completely and makes it difficult to comprehend before surgery. The development of imaging, mainly magnet…

Adultmedicine.medical_specialtyReconstructive surgeryanorectal malformations46 XX Disorders of Sex DevelopmentAdolescentEmbryonic DevelopmentUrogenital SystemKidneyCongenital AbnormalitiesPelvisAnus Imperforatemedicinemayer-rokitansky-küster-hauser syndromeHumanscongenital adrenal hyperplasiaCongenital adrenal hyperplasiaMayer-Rokitansky-Kuster-Hauser SyndromeAbnormalities MultipleIntestine LargeMullerian Ductsmayer-rokitansky-kuster-hauser syndrome; mayer–rokitansky–kuster–hauser syndrome; mayer-rokitansky-küster-hauser syndrome; congenital adrenal hyperplasia; anorectal malformations; bladder exstrophymedicine.diagnostic_testAdrenal Hyperplasia Congenitalbusiness.industryGenitourinary systemmayer–rokitansky–kuster–hauser syndromeUterusObstetrics and GynecologyInfantMagnetic resonance imagingAnatomyAnusmedicine.diseaseSpineSurgeryBladder exstrophymedicine.anatomical_structureReproductive MedicineSomitesEmbryologyVaginamayer-rokitansky-kuster-hauser syndromeFemalebusinessbladder exstrophy
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α5β1 integrin-mediated adhesion to fibronectin is required for axis elongation and somitogenesis in mice.

2011

The arginine-glycine-aspartate (RGD) motif in fibronectin (FN) represents the major binding site for α5β1 and αvβ3 integrins. Mice lacking a functional RGD motif in FN (FN(RGE/RGE)) or α5 integrin develop identical phenotypes characterized by embryonic lethality and a severely shortened posterior trunk with kinked neural tubes. Here we show that the FN(RGE/RGE) embryos arrest both segmentation and axis elongation. The arrest is evident at about E9.0, corresponding to a stage when gastrulation ceases and the tail bud-derived presomitic mesoderm (PSM) induces α5 integrin expression and assumes axis elongation. At this stage cells of the posterior part of the PSM in wild type embryos are tight…

IntegrinsMesodermIntegrinEmbryonic Developmentlcsh:MedicineApoptosisBiochemistryMiceSomitogenesisMolecular Cell BiologyCell AdhesionParaxial mesodermmedicineAnimalsSignaling in Cellular ProcessesReceptors VitronectinCell adhesionlcsh:ScienceBiologyAxis elongationCell ProliferationRGD motifMultidisciplinarybiologyGastrulationlcsh:RGene Expression Regulation DevelopmentalCell DifferentiationMolecular DevelopmentFibronectinsExtracellular MatrixCell biologyFibronectinmedicine.anatomical_structureSomitesCytochemistrybiology.proteinlcsh:QOligopeptidesCell Movement SignalingProtein BindingResearch ArticleDevelopmental BiologySignal TransductionPLoS ONE
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Expression analysis of jagged genes in zebrafish embryos

2005

The interaction of transmembrane Delta and Jagged/Serrate ligands with Notch receptors on neighboring cells is critically involved in cell specification during development. In zebrafish, the early expression of delta but not of jagged genes has been investigated in some detail. We have analyzed the sequence and embryonic expression pattern of the three zebrafish genes jagged1a, jagged1b, and jagged2. These genes, whose transcripts are detectable by in situ hybridization from early somitogenesis, are widely and dynamically expressed in embryos. Coexpression is limited, however, to the notochord and lens (jagged1a and jagged1b) and to the otic vesicle and pronephros (jagged1b and jagged2). Co…

Nervous systemanimal structuresNotchNotch signaling pathwayNotochordBiologystomatognathic systemSomitogenesisNotochordmedicineAnimalsPancreaSerrate-Jagged ProteinsSomitePlacodeZebrafishPhylogenyNotch signalingZebrafishGeneticsVertebrateCalcium-Binding ProteinsGene Expression Regulation DevelopmentalMembrane ProteinsCell BiologyZebrafish Proteinsbiology.organism_classificationCell biologyPronephrosmedicine.anatomical_structurezebrafish; Notch; JaggedEmbryoIntercellular Signaling Peptides and ProteinsPronephroOtic vesicleJaggedJagged-2 ProteinOtic PlacodesDevelopmental biologyIn situ hybridizationJagged/serrate geneEmbryo; In situ hybridization; Jagged/serrate genes; Nervous system; Notch signaling; Notochord; Pancreas; Placodes; Pronephros; Somites; Vertebrate; Zebrafish; Developmental Biology; Cell BiologyDevelopmental Biology
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