Search results for "Souris"
showing 10 items of 25 documents
Early Plasmodium-induced inflammation does not accelerate aging in mice
2019
10 pages; International audience; Aging is associated with a decline of performance leading to reduced reproductive output and survival. While the antagonistic pleiotropy theory of aging has attracted considerable attention, the molecular/physiological functions underlying the early-life benefits/late-life costs paradigm remain elusive. We tested the hypothesis that while early activation of the inflammatory response confers benefits in terms of protection against infection, it also incurs costs in terms of reduced reproductive output at old age and shortened longevity. We infected mice with the malaria parasite Plasmodium yoelii and increased the inflammatory response using an anti-IL-10 r…
Mouse olfactory sensory neurons' plasticity induced by postnatal odorant exposure: anatomical, molecular and physiological consequences
2012
Mouse olfactory sensory neurons' plasticity induced by postnatal odorant exposure: anatomical, molecular and physiological consequences. 8. FENS forum of neuroscience
Olfactory neurons plasticity : environment effects during development
2012
In order to investigate the consequences of postnatal odorant exposure on a specific population of olfactory sensory neurons (OSNs), we have taken the following experimental approach. MOR23-GFP mice were daily exposed to Lyral for 21 days starting at birth and three lines of investigations were carried out. Using anatomical analysis we observe that the density of OSNs expressing MOR23 decreases after odorant exposure. This decrease concerns primarily matures OSN (MOR23-OMP+). In order to study molecular changes within individual OSNs, mRNA levels for olfactory signaling pathway components were quantitatively analyzed using qPCR on GFP-labeled neurons (7 per mouse). mRNAs for CNGA2, PDE1C an…
Dispositif de pointage pour ordinateur : souris cartographique.
2007
N° publication pour les reproductions : 2 886 425 N° d'enregistrement national : 05 05250 Description en ligne : http://www.wipo.int/pctdb/fr/ia.jsp?ia=FR2006%2F001201&IA=FR2006001201&DISPLAY=DESC; La présente invention concerne un dispositif de pointage manuel pour ordinateur et autres terminaux électroniques, tel qu'une souris ou un pavé tactile par exemple, comportant un corps principal monté sur une base remarquable en ce qu'il comporte des moyens de suspension reliant le corps principal à la base, associés à au moins un capteur de déplacement mesurant le degré d' enfoncement vertical du corps principal, relativement à la base et à sa position initiale, afin d'activer une fonction de pr…
Involvment of docosanoïc acid (C22=0), and of very long chain fatty acids (tetracosanoïc acid (C24=0), hexacosanoïc acid (C26=0) in Alzheimer's disea…
2013
In the brain and in the plasma of patients with Alzheimer’s disease (AD), marked accumulation of C22:0 and of very long chain fatty acids (C24:0 ; C26:0) have been reported. Important decreases of docosahexaenoic acid (DHA; C22:6 n-3) have also been described as well as quantitative and qualitative modifications of plasmalogens. Altogether, these lipid modifications suggest an implication of peroxisomal metabolism disorders in the physiopathology of AD. Therefore, the biological activities of C22:0, C24:0 and C26:0 have been studied on human neuronal cells SK-N-BE. On these cells, the lipotoxicity of fatty acids (C22:0, C24:0 and C26:0) leads to various cellular modifications: topographical…
Un dispositif de prévisualisation qui améliore la navigation : comparaison entre une tablette tactile et une souris 3 D.
2015
International audience; C’est dans le cadre d’une action de recherche pluridisciplinaire (Sciences de l’Information et de la Communication, Psychologie, Ergonomie cognitive) que nous avons voulu vérifier l’hypothèse qu’un dispositif de prévisualisation pouvait améliorer les performances en recherche d’information pour des utilisateurs. L’objectif poursuivi est de tester une condition de prévisualisation en la déclinant sur une tablette tactile (expérience 1) et une souris 3 D incluant des fonctions de navigation modifiées (expérience 2). Deux modalités de recherche sont testées afin de pouvoir analyser les effets de ce dispositif. La première « normale » présente les caractéristiques classi…
Impact of obesity on the oro-sensory detection of dietary lipids in mice and humans
2013
Gustation is an essential parameter in the oro-sensory detection of dietary lipids. In mice and most likely in humans, the binding of long-chain fatty acids to the CD36 receptor plays a major role in this oral fat detection. Gustation is involved in the food choice (fat sensitivity) as well as in the preparation of the body to the fat inflow. This oral lipid sensing is highly regulated. As obesity seems to be responsible for an alteration of the basic tastes detection, the aim of this thesis was to investigate whether obesity can impair the oral lipid detection in both mice and humans. In humans, our data show that there is an alteration of the oral fat detection in some obese subjects who …
Rétine et lipides : de l'analyse à la physiopathologie
2016
Revue; Rétine et lipides : de l'analyse à la physiopathologie. Colloque du Collège National de Biochimie-Biologie Moléculaire Médicale (CNBBMM)
Accélérer la recherche d'informations grâce aux dispositifs d'interaction : Système de navigation pour les documents numériques
2005
International audience; Cet article présente une démarche qui vise à doter les outils d'interaction tactiles usuels (souris informatique, pavé tactile) d'une commande de prévisualisation des objets désignés. Nous décrivons la genèse du dispositif ainsi que les bénéfices attendus en termes d'agrément d'usage et d'accélération des recherches d'information dans certains contextes (retrouver une page qui a déjà été consultée par exemple). Nous limiterons notre description dans le cadre de cet article aux apports du dispositif à la consultation de documents numériques et en particulier aux sites Internet.
Enhanced proinflammatory response to the Candida albicans gpi7 null mutant by murine cells.
2008
International audience; The Candida albicans gpi7/gpi7 null mutant strain (Deltagpi7), which is affected in glycosylphosphatidylinositol (GPI) anchor biosynthesis, showed a reduced virulence following systemic infection of C57BL/6 mice. In vitro production of TNF-alpha, IL-6 and IL-1beta by macrophages in response to Deltagpi7 cells was significantly increased as compared to control (wild type GPI7/GPI7 and revertant gpi7/GPI7) cells; this probably contributes to the enhanced recruitment of neutrophils to the peritoneal cavity in response to Deltagpi7 cells. Survival of knockout mice for Toll-like receptor (TLR) 2 and TLR4 following intravenous injection of Deltagpi7 cells showed no signifi…