Search results for "South Africa"

showing 10 items of 105 documents

Novel Acylated Triterpene Glycosides from Muraltia heisteria

2002

Four new acylated triterpene glycosides (1-4) have been isolated as two inseparable mixtures of the trans- and cis-3,4,5-trimethoxycinnamoyl derivatives (1,2 and 3,4) from the roots of Muraltia heisteria. The structures of these compounds were elucidated by various 1D and 2D NMR techniques, including (1)H and (13)C, COSY, NOESY, HSQC, TOCSY, and HMBC experiments and FABMS. Compounds 3 and 4 were shown to be cytotoxic in a human colon cancer cell line but did not show any ability to potentiate in vitro cisplatin cytotoxicity.

StereochemistryAcylationSaponinPharmaceutical ScienceStereoisomerismPharmacognosyPlant RootsAnalytical ChemistrySouth AfricaTriterpeneDrug DiscoveryTumor Cells CulturedHumansOrganic chemistryNuclear Magnetic Resonance BiomolecularChromatography High Pressure LiquidPharmacologychemistry.chemical_classificationMolecular StructureChemistryHydrolysisOrganic ChemistryGlycosideStereoisomerismBiological activitySaponinsAntineoplastic Agents PhytogenicTriterpenesTerpenoidPolygalaceaeComplementary and alternative medicineMolecular MedicineCisplatinDrug Screening Assays AntitumorHT29 CellsTwo-dimensional nuclear magnetic resonance spectroscopyJournal of Natural Products
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Cytotoxic bufadienolides from the leaves of a medicinal plant Melianthus comosus collected in South Africa.

2020

Abstract From the leaves of South African medicinal plant Melianthus comosus, four previously undescribed bufadienolides, 16β-formyloxymelianthugenin (1), 2β-acetoxymelianthusigenin (2), 2β-hydroxy-3β,5β-di-O-acetylhellebrigenin (3), and 2β-acetoxy-5β-O-acetylhellebrigenin (4) were isolated together with two known bufadienolides. The structural elucidation of the compounds was based on 1D and 2D NMR spectroscopy, high-resolution mass spectrometry, and other spectroscopic methods. The relative configurations were determined by single-crystal X-ray crystallography analysis and NOESY correlations. The isolated compounds displayed strong cytotoxicity against MCF-7 breast cancer cells, sensitive…

StereochemistryMolecular ConformationMass spectrometry01 natural sciencesBiochemistrySouth AfricaStructure-Activity RelationshipCell Line TumorDrug DiscoveryIc50 valuesCytotoxic T cellHumansCytotoxicityMolecular BiologyCell ProliferationPlants MedicinalbiologyDose-Response Relationship Drug010405 organic chemistryChemistryOrganic ChemistryStereoisomerismMelianthus comosusbiology.organism_classificationAntineoplastic Agents Phytogenic0104 chemical sciencesBufanolidesPlant Leaves010404 medicinal & biomolecular chemistryBreast cancer cellsDrug Screening Assays AntitumorTwo-dimensional nuclear magnetic resonance spectroscopyBioorganic chemistry
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Association of Urogenital Symptoms with History of Water Contact in Young Women in Areas Endemic for S. haematobium. A Cross-Sectional Study in Rural…

2016

Female genital schistosomiasis is a neglected tropical disease caused by Schistosoma haematobium. Infected females may suffer from symptoms mimicking sexually transmitted infections. We explored if self-reported history of unsafe water contact could be used as a simple predictor of genital schistosomiasis. In a cross-sectional study in rural South Africa, 883 sexually active women aged 16–22 years were included. Questions were asked about urogenital symptoms and water contact history. Urine samples were tested for S. haematobium ova. A score based on self-reported water contact was calculated and the association with symptoms was explored while adjusting for other genital infections using m…

Stress incontinenceCross-sectional studyHealth Toxicology and Mutagenesislcsh:MedicineRural HealthUrine<i>Schistosoma haematobium</i>; female genital schistosomiasis; water contact; urogenital symptoms; sexually transmitted infectionsSchistosomiasis haematobiaSouth Africa0302 clinical medicineWater QualityWaterborne Diseases030212 general & internal medicineurogenital symptomsSchistosoma haematobiumbiologyGenital ulcerSchistosoma haematobiumFemalemedicine.symptommedicine.medical_specialtyAdolescent030231 tropical medicineSexually Transmitted Diseaseswater contactSchistosomiasisArticleDiagnosis DifferentialYoung Adult03 medical and health sciencesInternal medicinefemale genital schistosomiasismedicineAnimalsHumansSex organsexually transmitted infectionsbusiness.industrylcsh:RPublic Health Environmental and Occupational HealthWaterTropical diseaseEnvironmental Exposuremedicine.diseasebiology.organism_classificationCross-Sectional StudiesImmunologySelf ReportbusinessInternational Journal of Environmental Research and Public Health
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L'uso della comparazione giuridica e i diritti fondamentali nella sentenza della Corte costituzionale sudafricana Case CCT 23/96 "Certification of th…

2008

Obiettivo di questo studio è di esaminare, nel giudizio di conformità operato dalla Corte costituzionale sudafricana nel caso CCT 23/96 Certification of the Constitution of the Republic of South Africa, 1996, a conclusione del processo costituente sudafricano, i richiami comparatistici operati dalla Corte, per verificare il ruolo esercitato dal diritto straniero, in particolare nell’ambito delle previsioni inerenti i diritti fondamentali. L’analisi si sofferma quindi sulla natura dei riferimenti comparatistici, se generali o specifici, sul tipo di formante richiamato (normativo, giurisprudenziale o dottrinale), sull’importanza da dare al richiamo del diritto straniero e sull’uso costruttivo…

Sud Africa diritto straniero Corte costituzionaleSouth Africa Foreign Law Constitutional CourtSettore IUS/21 - Diritto Pubblico Comparato
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S. haematobium as a Common Cause of Genital Morbidity in Girls: A Cross-sectional Study of Children in South Africa

2013

Background Schistosoma (S.) haematobium infection is a common cause of genital morbidity in adult women. Ova in the genital mucosal lining may cause lesions, bleeding, pain, discharge, and the damaged surfaces may pose a risk for HIV. In a heterogeneous schistosomiasis endemic area in South Africa, we sought to investigate if young girls had genital symptoms and if this was associated with urinary S. haematobium. Methodology In a cross-sectional study of 18 randomly chosen primary schools, we included 1057 schoolgirls between the age of 10 and 12 years. We interviewed assenting girls, whose parents had consented to their participation and examined three urines from each of them for schistos…

Travel-Associated Diseasesmedicine.medical_specialtylcsh:Arctic medicine. Tropical medicineInfectious Disease ControlEpidemiologylcsh:RC955-962Cross-sectional studyUrologyGynecologic InfectionsVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Tropical medicine: 761SCHISTOSOMIASIS HAEMATOBIASexually Transmitted DiseasesHelminth InfectionUrineGlobal HealthPediatricsReproductive Tract InfectionsInfectious Disease EpidemiologySchistosomiasis haematobiaSouth AfricaParasitic DiseasesPrevalencemedicineSchistosomiasisAnimalsHumansSex organChildSchistosoma haematobiumSchoolsbiologyGenitourinary Infectionsbusiness.industrylcsh:Public aspects of medicinePublic Health Environmental and Occupational Healthlcsh:RA1-1270biology.organism_classificationSurgeryCross-Sectional StudiesInfectious DiseasesSchistosoma haematobiumNeglected tropical diseasesMedicineWomen's HealthFemalebusinessResearch ArticleNeglected Tropical DiseasesDemographyPLoS Neglected Tropical Diseases
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Un análisis de desarrollo dual : el caso de la República Sudafricana

1998

UNESCO::CIENCIES ECONÓMICASSouth African Studies:CIENCIES ECONÓMICAS [UNESCO]
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Notes on Afrotropical Cydnidae (Heteroptera) with emphasis on vehicle-mounted net samples and description of a new species from Liberia, West Africa

2019

Notes on the Cydnidae fauna in Liberia, sampled with a vehicle-mounted net, the species taxonomy and general distribution are reported, including the description of Chilocoris elongatus sp. nov. In addition, new country records are provided for Angola, Ethiopia, Gabon, Guine    a-Bissau, Namibia, Niger, Republic of South Africa, Sierra Leone, Tanzania, Togo, Uganda, and Zimbabwe. 

ZimbabweInsectaArthropodaFaunacar-netTanzaniaSierra LeoneSierra leoneWest africaHemipteraHeteropteraSouth AfricadistributionAnimaliaAnimalsUgandaGabonChilocorisCydnidaeEcology Evolution Behavior and SystematicsTaxonomynew speciesnew country recordsbiologyGeneral distributionHeteropteraBiodiversityLiberiabiology.organism_classificationNamibiaArchaeologyTanzaniaAngolaHemiptera (awaiting allocation)Animal Science and ZoologyTaxonomy (biology)EthiopiaAnimal DistributionCydnidaeAfrotropicsZootaxa
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Moringa oleifera supplemented foods in South Africa : A multidisciplinary approach combining consumer studies with physico-chemical and nutritional a…

2021

Malnutrition is a major challenge in South Africa (SA), particularly in Eastern Cape and Limpopo provinces, which are predominantly black and historically disadvantaged. This thesis aims to assess the potential of Moringa oleifera (MO) as a source of nutritional improvement in the diets of mothers and their children in these provinces. Known for its nutritional benefits, MO is a plant native to India, now cultivated in SA but not widely used for human nutrition. A two-part approach was followed in this thesis. The first part aims to understand how MO is perceived by consumers and how it can be integrated into the South African food repertory. A study of the knowledge, beliefs and consumptio…

[SDV.SA]Life Sciences [q-bio]/Agricultural sciencesMoringa oleiferaSouth Africa[SDV.SA] Life Sciences [q-bio]/Agricultural sciencesSensoryBeliefsAfrique du SudConsumers habitsDigestibilityDigestibilitéCroyancesSensorielHabitudes des consommateurs
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André Brink and the Afrikaner Heritage

2004

This paper shows how André Brink, dissident Afrikaans writer, tried to write against his heritage. The most visible strategy consisted in redefining Afrikanerdom as dissidence and as africanity. The notion of betrayal was systematically reversed so that the Afrikaners who supported the Afrikaner regime were presented as the real traitors. Yet dissidence was not an easy position for Brink and both he and his heroes had ambivalent positions.

[SHS.LITT] Humanities and Social Sciences/LiteratureAfrikanerlittérature sud-africainefiliation[SHS.LITT]Humanities and Social Sciences/LiteratureSouth African literature[ SHS.LITT ] Humanities and Social Sciences/LiteratureAndré Brinkapartheid
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Post-Apartheid Gothic. White South African Writers and Space

2021

International audience; Post-Apartheid Gothic: White South African Writers and Space analyzes the representation of space in recent works by South African writers. By combining analytical tools borrowed from Gothic studies with geocritical and postcolonial approaches, Mélanie Joseph-Vilain assesses the literary mechanisms utilized by Damon Galgut, Henrietta Rose-Innes, Lauren Beukes, Justin Carwright, and Lynn Freed to negotiate the complexities of post-apartheid identities in their fiction. Joseph-Vilain argues that the literary representations of emblematic places, real or imagined (the home, the farm, the city or the “non-places” of dystopia), express and reveal anxieties linked to the s…

[SHS.LITT] Humanities and Social Sciences/LiteratureAfrique du Sud - littératureSouth AfricaVilleDystopie -- Dans la littérature[SHS.LITT]Humanities and Social Sciences/LiteratureGéocritiqueScience FictionGothic literaturePost-ApartheidLiterary geographyLiterature & literary studiesDystopia
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