Search results for "Spar"
showing 10 items of 1739 documents
Amphiphilic poly(hydroxyethylaspartamide) derivative-based micelles as drug delivery systems for ferulic acid
2008
Self-assembling micelles, potentially useful as drug delivery systems for ferulic acid (FA), were obtained in aqueous media from amphiphilic alpha,beta-poly(N-2-hydroxyethyl)-dl-aspartamide (PHEA) copolymers bearing at the polyamino acidic backbone both poly(ethyleneglycol) (2000 or 5000 Da) and hexadecylamine (C(16)) moieties, at a concentration of 7 x 10(- 3) and 4 x 10(- 3) g/l, respectively, with nanometre size and negative zeta potential. These micelles were able to entrap FA and to release it in a prolonged way in phosphate buffer solution at pH 7.4 and human plasma. These systems were also stable in storage conditions and have no cytotoxic effects on Caco-2, 16 HBE, HuDe and K562 cel…
Nonlinear pulse deceleration using photorefractive four-wave mixing
2009
We investigate the possibilities of the backward four-wave coupling based on the nonlocal photorefractive response for the nonlinear deceleration of light pulses. The presence of an additional external variable parameter—the pump intensity ratio—allows to improve the output characteristics of the decelerated pulses compared to those typical of the two-wave coupling. In particular, large delay times of the output pulses can be achieved without their strong amplification. This positive distinctive feature of the pulse deceleration occurs far from threshold of the mirrorless optical oscillation.
Sign and Rank Covariance Matrices: Statistical Properties and Application to Principal Components Analysis
2002
In this paper, the estimation of covariance matrices based on multivariate sign and rank vectors is discussed. Equivariance and robustness properties of the sign and rank covariance matrices are described. We show their use for the principal components analysis (PCA) problem. Limiting efficiencies of the estimation procedures for PCA are compared.
Value congruence in health care priority setting: social values, institutions and decisions in three countries
2014
AbstractMost developed democracies have faced the challenge of priority setting in health care by setting up specialized agencies to take decisions on which medical services to include in public health baskets. Under the influence of Daniels and Sabin’s seminal work on the topic, agencies increasingly aim to fulfil criteria of procedural justice, such as accountability and transparency. We assume, however, that the institutional design of agencies also and necessarily reflects substantial value judgments on the respective weight of distributive principles such as efficiency, need and equality. The public acceptance of prioritization decisions, and eventually of the health care system at lar…
A Roof Tile from 1678 Found in Calasparra (Murcia) as an Abiding Medium of Writing
2017
Analysis of a red clay roof tile which bears an heretofore unknown inscription of the late 'procesal' script style and humanistic characters along with the date 1678, marking its exact year of manufacture. This tile was found on the roof of an old barn structure in ruins, located on 'Horno de Calasparra' Street (Murcia), before its demolition. We will also point out some of the more significant aspects of the historic profession of tile making, which has all but disappeared. Se expone a continuación una teja de barro cocido en cuyo lomo se observa incisa una inédita frase, presentando una escritura de tipo procesal tardío, con caracteres ya humanísticos, y una fecha, 1678, la cual marca el …
Un-rooted grafted cuttings for eggplant plug-transplant production and shipping: simulated transportation and healing requirements
2019
Vegetable grafting is one of the most effective eco-friendly techniques to overcome pests and soilborne diseases in modern cropping systems of fruiting vegetables. Due to the increased farmers’ preference for grafted seedlings of high quality and better performance, the use of vegetable grafted plants is rapidly spreading and expanding over the world and intensive researches on new commercial production systems are under way. However, in many areas of the world, due to the high cost of skilled manpower, the use of grafted plug plants is still limited causing a relatively slow development of the grafting nursery industry. The aim of this work was to evaluate a possible use of un-rooted graft…
Differential geometric LARS via cyclic coordinate descent method
2012
We address the problem of how to compute the coefficient path implicitly defined by the differential geometric LARS (dgLARS) method in a high-dimensional setting. Although the geometrical theory developed to define the dgLARS method does not need of the definition of a penalty function, we show that it is possible to develop a cyclic coordinate descent algorithm to compute the solution curve in a high-dimensional setting. Simulation studies show that the proposed algorithm is significantly faster than the prediction-corrector algorithm originally developed to compute the dgLARS solution curve.
Inhalable nano into micro dry powders for ivacaftor delivery: The role of mannitol and cysteamine as mucus-active agents.
2020
In this paper the innovative approach of Nano into micro (NiM9 was developed to produce Nanoparticles loaded Ivacaftor to incorporate into mannitol or mannitol/cysteamine micromatrices for drug pulmonary administration in CF. Nanoparticles composed by a mixture of two polyhydrohydroxyethtylaspartamide copolymers containing a loading of Ivacaftor of 15.5 % w/w were produced. These Nanoparticles were incorporated into microparticles to obtain NiM that were characterized in terms of size and size distribution, interaction with CF-AM by rheological and turbidimetric studies as well as by aerodynamic diameter measurements. Finally the activity of Ivacaftor into these NiM was evaluated by in vitr…
Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins.
2001
The L1 adhesion molecule plays an important role in axon guidance and cell migration in the nervous system. L1 is also expressed by many human carcinomas. In addition to cell surface expression, the L1 ectodomain can be released by a metalloproteinase, but the biological function of this process is unknown. Here we demonstrate that membrane-proximal cleavage of L1 can be detected in tumors and in the developing mouse brain. The shedding of L1 involved a disintegrin and metalloproteinase (ADAM)10, as transfection with dominant-negative ADAM10 completely abolishes L1 release. L1-transfected CHO cells (L1-CHO) showed enhanced haptotactic migration on fibronectin and laminin, which was blocked …
Amyloid Precursor-like Protein 1 Influences Endocytosis and Proteolytic Processing of the Amyloid Precursor Protein
2005
Ectodomain shedding of the amyloid precursor protein (APP) is a key regulatory step in the generation of the Alzheimer disease amyloid beta peptide (Abeta). The molecular mechanisms underlying the control of APP shedding remain little understood but are in part dependent on the low density lipoprotein receptor-related protein (LRP), which is involved in APP endocytosis. Here, we show that the APP homolog APLP1 (amyloid precursor-like protein 1) influences APP shedding. In human embryonic kidney 293 cells expression of APLP1 strongly activated APP shedding by alpha-secretase and slightly reduced beta-secretase cleavage. As revealed by domain deletion analysis, the increase in APP shedding re…