Search results for "Spar"
showing 10 items of 1739 documents
Indirect Discrimination and School Segregation of Roma Children in the Czech Republic
2018
In DH v. Czech Republic (2007), the Czech government argued that Roma parents consented to the assignment of their children to ‘special’ schools. According to the government, parental consent undermined the claim that the disproportionate assignment of Roma children to inferior schools amounted to discrimination. The court rejected the argument, finding as a matter of law that parents could not choose to subject their children to discriminatory education, and as a matter of fact that the parents’ consent was not informed. Since the judgment, the Czech government continues to disproportionately assign Roma children to inferior schools, but it has revised the procedure they use to obtain pare…
Virulence and Molecular Typing of Vibrio harveyi Strains Isolated from Cultured Dentex, Gilthead Sea Bream and European Sea Bass
2003
Vibrio harveyi was isolated from internal organs or ulcers of diseased and apparently healthy gilthead sea bream (Sparus aurata) and European sea bass (Dicentrarchus labrax) cultured in several fish farms located on the Spanish Mediterranean coast. The prevalence of the bacterium was significantly higher in European sea bass than in gilthead sea bream, and was closely related to the season in both fish species, occurring almost exclusively on warm months (June to November). After phenotypic characterization, a selection of forty five isolates from gilthead sea bream, sea bass, and several isolates previously obtained from common dentex (Dentex dentex) of the same area, were molecularly type…
The disintegrin ADAM9 indirectly contributes to the physiological processing of cellular prion by modulating ADAM10 activity
2005
The cellular prion protein (PrP(c)) is physiologically cleaved in the middle of its 106-126 amino acid neurotoxic region at the 110/111 downward arrow112 peptidyl bond, yielding an N-terminal fragment referred to as N1. We recently demonstrated that two disintegrins, namely ADAM10 and ADAM17 (TACE, tumor necrosis factor alpha converting enzyme) participated in both constitutive and protein kinase C-regulated generation of N1, respectively. These proteolytic events were strikingly reminiscent of those involved in the so-called "alpha-secretase pathway" that leads to the production of secreted sAPPalpha from betaAPP. We show here, by transient and stable transfection analyses, that ADAM9 also…
Tumor necrosis factor-alpha converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulat…
2003
Tumor necrosis factor-alpha converting enzyme (TACE or ADAM17) is a member of the ADAM (a disintegrin and metalloproteinase) family of type I membrane proteins and mediates the ectodomain shedding of various membrane-anchored signaling and adhesion proteins. TACE is synthesized as an inactive zymogen, which is subsequently proteolytically processed to the catalytically active form. We have identified the proprotein-convertases PC7 and furin to be involved in maturation of TACE. This maturation is negatively influenced by the phorbol ester phorbol-12-myristate-13-acetate (PMA), which decreases the cellular amount of the mature form of TACE in PMA-treated HEK293 and SH-SY5Y cells. Furthermore…
Computational Models That Matter During a Global Pandemic Outbreak
2020
The COVID-19 pandemic is causing a dramatic loss of lives worldwide, challenging the sustainability of our health care systems, threatening economic meltdown, and putting pressure on the mental health of individuals (due to social distancing and lock-down measures). The pandemic is also posing severe challenges to the scientific community, with scholars under pressure to respond to policymakers’ demands for advice despite the absence of adequate, trusted data. Understanding the pandemic requires fine-grained data representing specific local conditions and the social reactions of individuals. While experts have built simulation models to estimate disease trajectories that may be enough to gu…
Modulational instability and generation of self-induced transparency solitons in resonant optical fibers
2009
International audience; We consider continuous-wave propagation through a fiber doped with two-level resonant atoms, which is described by a system of nonlinear Schrodinger-Maxwell-Bloch (NLS-MB) equations. We identify the modulational instability (MI) conditions required for the generation of ultrashort pulses, in cases of both anomalous and normal GVD (group-velocity dispersion). It is shown that the self-induced transparency (SIT) induces non-conventional MI sidebands. The main result is a prediction of the existence of both bright and dark SIT solitons in the anomalous and normal GVD regimes.
Analyzing big datasets of genomic sequences: fast and scalable collection of k-mer statistics
2019
Abstract Background Distributed approaches based on the MapReduce programming paradigm have started to be proposed in the Bioinformatics domain, due to the large amount of data produced by the next-generation sequencing techniques. However, the use of MapReduce and related Big Data technologies and frameworks (e.g., Apache Hadoop and Spark) does not necessarily produce satisfactory results, in terms of both efficiency and effectiveness. We discuss how the development of distributed and Big Data management technologies has affected the analysis of large datasets of biological sequences. Moreover, we show how the choice of different parameter configurations and the careful engineering of the …
The Rise of Distributed Artificial Intelligence Through Shared Data and Cloud Solutions
2021
Decision-makers of present times encounter influence by an ever-increasing emotional condition created by social media, market trends, experience, and historical facts. The concept of mixed human and artificial intelligence is one of the most underrated business drivers today, and conspiracy theories, fixed mindset, and legacy systems are slowing down collective evolution. This paper intends to contribute to the everyday awareness of data sharing through cloud solutions and services. It opens a wide range of possibilities for new solutions and insights that endorse a collaborative culture where a growth mindset paired with transparency and ethics reduces time-to-value in businesses, governm…
Optical remote sensing and the retrieval of terrestrial vegetation bio-geophysical properties – A review
2015
Abstract: Forthcoming superspectral satellite missions dedicated to land monitoring, as well as planned imaging spectrometers, will unleash an unprecedented data stream. The processing requirements for such large data streams involve processing techniques enabling the spatio-temporally explicit quantification of vegetation properties. Typically retrieval must be accurate, robust and fast. Hence, there is a strict requirement to identify next-generation bio-geophysical variable retrieval algorithms which can be molded into an operational processing chain. This paper offers a review of state-of-the-art retrieval methods for quantitative terrestrial bio-geophysical variable extraction using op…
Praktiski vizuāli datu vaicājumi
2019
Maģistra darbā ir aprakstīts par saistītajiem datiem, RDF, SPARQL vaicājumiem, ViziQuer rīku, kas paradzēts praktiski vizuāli datu vaicājumu veidošanai, tā darbības būtību, pamatidejām, kā arī piekļuves punktiem, kuros iespējams iegūt datus izmantojot SPARQL vaicājumus. Rīku, ar kura palīdzību iespējams veikt vizuālus datu vaicājumus, šobrīd īsti nav, tāpēc, ņemot vērā to, ka vizuāli sastādīt vaicājumus ir ērtāk kā pārzināt dažādas sintakses, ir svarīgi veikt izpēti un paātrināt attīstību šajā virzienā. Izpētot pieejamos resursus par augstāk minētajām tēmām, veicot praktiskus izmēģinājumus un aplūkojot iegūtos rezultātus, tika izdarīti vairāki secinājumi par ViziQuer rīka darbību un iespēja…