Search results for "Spar"
showing 10 items of 1739 documents
A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model
2004
Alzheimer disease (AD) is characterized by excessive deposition of amyloid beta-peptides (A beta peptides) in the brain. In the nonamyloidogenic pathway, the amyloid precursor protein (APP) is cleaved by the alpha-secretase within the A beta peptide sequence. Proteinases of the ADAM family (adisintegrin and metalloproteinase) are the main candidates as physiologically relevant alpha-secretases, but early lethality of knockout animals prevented a detailed analysis in neuronal cells. To overcome this restriction, we have generated transgenic mice that overexpress either ADAM10 or a catalytically inactive ADAM10 mutant. In this report we show that a moderate neuronal overexpression of ADAM10 i…
NMDA receptor antagonist treatment increases the production of new neurons in the aged rat hippocampus
2002
The production of new neurons declines during adulthood and persists, although at very low levels, in the aged hippocampus. Since neurogenesis in young adults has been related to learning and memory, its reduction may contribute to the age-related impairments in these abilities. Adrenalectomy (ADX) enhances neurogenesis in the aged hippocampus, although it also induces neuronal cell death. Since the administration of an NMDA receptor antagonist enhances neurogenesis in young adult rats without deleterious morphological effects, we have tested whether neurogenesis could be reactivated in aged rats. Our study shows that cell proliferation, cell death, neurogenesis and the number of radial gli…
On the relationship between occlusion times and in-car glance durations in simulated driving
2023
Drivers have spare visual capacity in driving, and often this capacity is used for engaging in secondary in-car tasks. Previous research has suggested that the spare visual capacity could be estimated with the occlusion method. However, the relationship between drivers’ occlusion times and in-car glance duration preferences has not been sufficiently investigated for granting occlusion times the role of an estimate of spare visual capacity. We conducted a driving simulator experiment (N = 30) and investigated if there is an association between drivers’ occlusion times and in-car glance durations in a given driving scenario. Furthermore, we explored which factors and variables could explain t…
Colloidal Self-assembled Nanosphere Arrays for Plasmon-enhanced Light Trapping in Thin Film Silicon Solar Cells
2014
To realize high-efficiency thin-film silicon solar cells it is crucial to develop light-trapping methods that can increase absorption of the near- bandgap light in the silicon material. That can be achieved using the far-field scattering properties of metal nanoparticles (MNP) sustaining surface plasmons. The MNPs should be inserted in the back of the cell, embedded in the transparent conductive oxide (TCO) layer which separates the rear mirror from the silicon layers. In this way, a plasmonic back reflector (PBR) is constructed that can redirect light at angles away from the incidence direction and thereby increase its path length in the cell material. In this work, a novel technique is pr…
“They’re always in a hurry” – Older people´s perceptions of access and recognition in health and social care services
2019
The article examines older people's perceptions of quality of life from the perspective of access and use of health and social care services. The data include focus group discussions with older people living alone. The data were analysed using thematic analysis focusing on the older people's collective views on health and social care services as supportive or restrictive factors for their quality of life. Two central themes were present in all the focus group discussions: the importance of accessing services and information regarding the services, and need for recognition within the services/by the professionals. Both themes were connected to the older people's desire to maintain autonomy i…
Kampania wielkopolska i kujawska Chryzostoma Jana Niemiry Gniazdowskiego
2020
W pracy przedstawiony został przebieg kampanii wielkopolsko-kujawskiej, która trwała dziewięć miesięcy, od lutego do października 1716 r. Przyjętym przez tarnogrodzian celem było rozszerzenie związku konfederackiego na Wielkopolskę właściwą, a następnie Kujawy i Pomorze. Poprowadzona została przez regimentarza, pułkownika Chryzostoma Jana Niemirę Gniazdowskiego - jeśli nie najzdolniejszego, to niewątpliwe najbardziej rzutkiego, skorego do podejmowania ryzykownych akcji, a przy tym skutecznego dowódcę konfederackiego. Jego przeciwnikiem były wojska królewskie złożone z oddziałów saski i polskich, dowodzone przez generała porucznika Kaspra von Seidlitz oraz generałów majorów Aleksandra Dietri…
La última esperanza
1999
Valeria Tatano e AA. VV. Oltre la trasparenza.
2012
Recensione del testo di VALERIA TATANO (CURATORE), Oltre la trasparenza. Riflessioni sull’impiego del vetro in architettura, Officina, Roma 2008. La storia del vetro in edilizia coincide con la ricerca della trasparenza: grazie al vetro la luce può entrare negli ambienti che, al tempo stesso, sono protetti dagli agenti atmosferici. Negli ultimi anni, con l’evoluzione tecnologica, abbiamo assistito a una rivoluzione delle possibilità di impiego di tale materiale. Il testo Oltre la trasparenza offre uno scenario completo sui possibili usi innovativi del vetro nell’architettura contemporanea; obiettivo dell’articolo è quello di evidenziare i caratteri essenziali di tale evoluzione.
Turisti a Sparta. Il passato che non torna e l’invenzione della tradizione
2010
Un elemento che sembra concorrere in misura determinante alla definizione del turismo come prassi socioculturale diffusa è la tensione tra l’aspettativa della dimensione esotica e straniante da un lato, e dall’altro la tendenza all’inglobamento “autoidentitario”. Questa definizione consente di riflettere sui due livelli qui in gioco: lo spostamento e l’identità. La vulgata che fa iniziare nel XVII secolo le prime tracce di pratiche turistiche si scontra con testimonianze rilevanti su pratiche comparabili nel mondo antico. Già Platone (Leggi XII 949-950) teorizza l’utilità filosofica del “turismo” intellettuale. Il caso più interessante è però quello del “turismo” culturale a Sparta, divenut…
Notes on Using the Hidden Asset or the Contribution Asset to Compile the Actuarial Balance for Pay-as-You-Go Pension Systems
2010
The aim of this paper is twofold: to determine the connection between the “contribution asset” and the “hidden asset” and to discover whether using either of them to compile the actuarial balance in Swedish-type pay-as-you-go pension systems will provide a reliable solvency indicator. We develop an overlapping generations model and apply it to the defined benefit pay-as-you-go system, although it would be just as valid for NDC systems. On the theoretical side the main conclusion is that, despite their very different natures, in a simplified scenario the contribution asset and the hidden asset could coincide if r - the real rate of interest - is equal to the growth in the wage bill. On the a…