Search results for "Spatial"
showing 10 items of 2121 documents
A Novel Radiotherapeutic Approach to Treat Bulky Metastases Even From Cutaneous Squamous Cell Carcinoma: Its Rationale and a Look at the Reliability …
2022
IntroductionMetastatic cutaneous squamous cell carcinoma (cSCC) is a very rare condition. The lack of definition of an oligometastatic subgroup means that there is no consensus for its treatment, unlike the mucosal head and neck counterpart. Like the latter, the cutaneous form is able to develop bulky tumor masses. When this happens, the classic care approach is just for palliative intent due to a likely unfavorable benefit–risk balance typical of aggressive treatments. Here we proposed a novel radiotherapy (RT) technique to treat bulky metastases from cSCC in the context of an overall limited tumor burden and tried to explain its clinical outcome by the currently available mathematical rad…
Spatial cumulant models enable spatially informed treatment strategies and analysis of local interactions in cancer systems
2023
AbstractTheoretical and applied cancer studies that use individual-based models (IBMs) have been limited by the lack of a mathematical formulation that enables rigorous analysis of these models. However, spatial cumulant models (SCMs), which have arisen from theoretical ecology, describe population dynamics generated by a specific family of IBMs, namely spatio-temporal point processes (STPPs). SCMs are spatially resolved population models formulated by a system of differential equations that approximate the dynamics of two STPP-generated summary statistics: first-order spatial cumulants (densities), and second-order spatial cumulants (spatial covariances).We exemplify how SCMs can be used i…
Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor.
2012
Allosteric modulation of G-protein–coupled receptors represents a key goal of current pharmacology. In particular, endogenous allosteric modulators might represent important targets of interventions aimed at maximizing therapeutic efficacy and reducing side effects of drugs. Here we show that the anti-inflammatory lipid lipoxin A 4 is an endogenous allosteric enhancer of the CB 1 cannabinoid receptor. Lipoxin A 4 was detected in brain tissues, did not compete for the orthosteric binding site of the CB 1 receptor (vs. 3 H-SR141716A), and did not alter endocannabinoid metabolism (as opposed to URB597 and MAFP), but it enhanced affinity of anandamide at the CB1 receptor, thereby potentiating …
A global Canopy Water Content product from AVHRR/Metop
2020
Abstract Spatially and temporally explicit canopy water content (CWC) data are important for monitoring vegetation status, and constitute essential information for studying ecosystem-climate interactions. Despite many efforts there is currently no operational CWC product available to users. In the context of the Satellite Application Facility for Land Surface Analysis (LSA-SAF), we have developed an algorithm to produce a global dataset of CWC based on data from the Advanced Very High Resolution Radiometer (AVHRR) sensor on board Meteorological–Operational (MetOp) satellites forming the EUMETSAT Polar System (EPS). CWC reflects the water conditions at the leaf level and information related …
Retrieving and Validating Leaf and Canopy Chlorophyll Content at Moderate Resolution: A Multiscale Analysis with the Sentinel-3 OLCI Sensor
2021
ESA’s Eighth Earth Explorer mission “FLuorescence EXplorer” (FLEX) will be dedicated to the global monitoring of the chlorophyll fluorescence emitted by vegetation. In order to properly interpret the measured fluorescence signal, essential vegetation variables need to be retrieved concomitantly. FLEX will fly in tandem formation with Sentinel-3 (S3), which conveys the Ocean and Land Color Instrument (OLCI) that is designed to characterize the atmosphere and the terrestrial vegetation at a spatial resolution of 300 m. In support of FLEX’s preparatory activities, this paper presents a first validation exercise of OLCI vegetation products against in situ data coming from the 2018 FLEXSense cam…
On the Use of the Eddy Covariance Latent Heat Flux and Sap Flow Transpiration for the Validation of a Surface Energy Balance Model
2018
Actual evapotranspiration is assessed via surface energy balance at an hourly rate. However, a robust estimation of daily evapotranspiration from hourly values is required. Outcomes of surface energy balance are frequently determined via measures of eddy covariance latent heat flux. Surface energy balance can be applied on images acquired at different times and spatial resolutions. In addition, hourly actual evapotranspiration needs to be integrated at a daily rate for operational uses. Questions arise whether the validation of surface energy balance models can benefit from complementary in situ measures of latent heat flux and sap flow transpiration. Here, validation was driven by image ac…
Global L-band vegetation volume fraction estimates for modeling vegetation optical depth
2021
The attenuation of microwave emissions through the canopy is quantified by the vegetation optical depth (VOD), which is related to the amount of water, the biomass and the structure of vegetation. To provide microwave-derived plant water estimates, one must account for biomass/structure contributions in order to extract the water component from the VOD. This study uses Aquarius scatterometer data to build an L-band global seasonality of vegetation volume fraction (d), representative of biomass/structure dynamics. The dynamic range of d is adapted for its application in a gravimetric moisture (Mg) retrieval model. Results show that d ranging from 0 to 3.35.10- 4 is needed for modelling physi…
Spatial throughfall heterogeneity in a montane rain forest in Ecuador: Extent, temporal stability and drivers
2009
Summary The drivers of spatial throughfall heterogeneity are still not fully understood. At an undisturbed forest site in the Ecuadorian Andes with ca. 2600 mm of annual rainfall we determined the accuracy of throughfall measurements by comparing Hellmann-type funnel gauges with troughs. At the same undisturbed and a managed, selectively-logged forest site we determined spatial variability of throughfall, temporal stability of spatial variability and the controls of spatial throughfall variability using a 4-year dataset in weekly resolution. There were no systematic differences between the collected volumes of funnel gauges and troughs. Based on the statistical distribution of annual throug…
Mapping Carbon Stocks In Central And South America With Smap Vegetation Optical Depth
2019
Mapping carbon stocks in the tropics is essential for climate change mitigation. Passive microwave remote sensing allows estimating carbon from deep canopy layers through the Vegetation Optical Depth (VOD) parameter. Although their spatial resolution is coarser than that of optical vegetation indices or airborne Lidar data, microwaves present a higher penetration capacity at low frequencies (L-band) and avoid cloud masking. This work compares the relationships of airborne carbon maps in Central and South America with both (i) SMAP L-band VOD at 9 km gridding and (ii) MODIS Enhanced Vegetation Index (EVI). Models to estimate carbon stocks are built from these two satellite-derived variables.…
Prototyping of Land-SAF leaf area index algorithm with VEGETATION and MODIS data over Europe
2009
Abstract The Satellite Application Facility on Land Surface Analysis (Land-SAF) aims to provide land surface variables for the meteorological and environmental science communities from EUMETSAT satellites. This study assesses the performance of a simplified (i.e. random distribution of vegetation is assumed) version of the Land-SAF algorithm for the estimation of Leaf Area Index (LAI) when prototyped with VEGETATION (processed in CYCLOPES program) and MODIS reflectances. The prototype estimates of LAI are evaluated both by comparison with validated CYCLOPES and MODIS LAI products derived from the same sensors and directly through comparison with ground-based estimates. Emphasis is given on …