Search results for "Spectrometry"

showing 10 items of 3206 documents

Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease.

2022

Funder: European Commission

ALTtype 2 diabetes mellitusROC receiving operator characteristicaspartate aminotransferaseHSDLDL low-density lipoproteinUHPLC ultrahigh-performance liquid chromatographyROCHCCNon-alcoholic steatohepatitisGCPCANASHGastroenterology2-HB 2-hydroxybutanoic acid; 3-HB 3-hydroxybutanoic acid; ALT alanine aminotransferase; AST aspartate aminotransferase; CE cholesterol ester; Cer ceramide; FFA free fatty acid; FLIP Fatty Liver Inhibition of Progression; Fibrosis; GC gas chromatography; HCC hepatocellular carcinoma; HSD honest significant difference; LC lipid cluster; LDL low-density lipoprotein; LM lipid and metabolite; LMC lipid metabolite and clinical variable; LPC lysophosphatidylcholine; Lipidomics; Mass spectrometry; Metabolomics; NAFL non-alcoholic fatty liver; NAFLD non-alcoholic fatty liver disease; NAS NASH activity score; NASH non-alcoholic steatohepatitis; NIDDK NASH-CRN National Institute of Digestive Diseases and Kidney NASH Clinical Research Network; NRR non-rejection rate; Non-alcoholic steatohepatitis; PC(O) ether PC; PC phosphatidylcholine; PCA principal component analysis; PE phosphatidylethanolamine; QTOFMS quadrupole-time-of-flight mass spectrometry; ROC receiving operator characteristic; SAF steatosis activity and fibrosis; SM sphingomyelin; T2DM type 2 diabetes mellitus; TG triacylglycerol; UHPLC ultrahigh-performance liquid chromatographySAFSAF steatosis activity and fibrosisLM lipid and metabolitehonest significant differenceHSD honest significant differenceTG triacylglycerolnon-rejection ratecholesterol esterPCPEGC gas chromatographyfree fatty acidFLIPNASH non-alcoholic steatohepatitisNIDDK NASH-CRN National Institute of Digestive Diseases and Kidney NASH Clinical Research NetworkBIOMARKERST2DMPE phosphatidylethanolamineLDLlipidNAFLDFFA free fatty acid2-HBMetabolomicsNAFL non-alcoholic fatty liverLMCphosphatidylcholineScience & TechnologySM sphingomyelinGastroenterology & HepatologyMass spectrometryactivitynutritional and metabolic diseasesT2DM type 2 diabetes mellitusACIDSreceiving operator characteristicdigestive system diseasesquadrupole-time-of-flight mass spectrometryLC lipid clusterlow-density lipoproteinNAS2-HB 2-hydroxybutanoic acidNAS NASH activity scoreQTOFMSether PCNRRSCORING SYSTEMprincipal component analysisgas chromatographyLC2-hydroxybutanoic acidPROGRESSIONAST aspartate aminotransferaseLMPC phosphatidylcholinePC(O)MARKERSUHPLCsteatosisTOOLImmunology and AllergyINSULIN-RESISTANCECerSMFatty Liver Inhibition of Progressionhepatocellular carcinoma2-HB 2-hydroxybutanoic acid NIDDK NASH-CRN National Institute of Digestive Diseases and Kidney NASH Clinical Research Network NRR non-rejection rate Non-alcoholic steatohepatitis PC(O) ether PC PC phosphatidylcholine PCA principal component analysis PE phosphatidylethanolamine QTOFMS quadrupole-time-of-flight mass spectrometry ROC receiving operator characteristic SAF steatosis activity and fibrosis SM T2DM type 2 diabetes mellitus TG triacylglycerol UHPLC ultrahigh-performance liquid chromatographyultrahigh-performance liquid chromatographyCELPC3-HBNAFLnon-alcoholic fatty liverTGtriacylglycerolNRR non-rejection rateLife Sciences & BiomedicineNAFLD non-alcoholic fatty liver diseaseFLIP Fatty Liver Inhibition of Progressionalanine aminotransferasemetaboliteCer ceramideCE cholesterol estersphingomyelinlysophosphatidylcholineand fibrosisALT alanine aminotransferaseInternal MedicineceramideNational Institute of Digestive Diseases and Kidney NASH Clinical Research NetworkAST3-HB 3-hydroxybutanoic acidQTOFMS quadrupole-time-of-flight mass spectrometryPCA principal component analysisLPC lysophosphatidylcholineHepatologynon-alcoholic fatty liver diseaseand clinical variablePC(O) ether PC3-hydroxybutanoic acidFibrosisNASH activity scoreNIDDK NASH-CRNlipid clusterlipid and metabolitephosphatidylethanolamineLipidomicsLMC lipid metabolite and clinical variableFFAHCC hepatocellular carcinomaJHEP reports : innovation in hepatology
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Collision induced decomposition of AOT5YB2+: an unespected intracluster rearrangment

2014

AOT Yb cluster mass spectrometry gas phase rearrangment
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Analysis of emerging and related pollutants in aquatic biota

2020

Water bodies cover approximately 70 % of the earth s surface, making them ecosystems with a high environmental value and the habitat for numerous species of flora and fauna. Emerging pollutants (EPs) are ubiquitous anthropogenic compounds of environmental concern that can be found at different concentration levels in matrices such as sediment, water and aquatic biota. In addition, EPs can be bioaccumulated and biomagnified, inducing adverse effects on biota, and posing a risk to humans when contaminated biota is consumed. Unlike abiotic matrices, the occurrence of EPs in aquatic biota has not been widely studied. This is probably because their complexity, due to the presence of lipids, prot…

Abiotic componentPollutantAquatic biotaGas chromatographySpectrometryFauna010401 analytical chemistryLiquid chromatographyMethodologySedimentBiotaExtraction010501 environmental sciencesAquatic biota01 natural sciences0104 chemical sciencesAnalytical ChemistryLipids removalHabitatEnvironmental chemistryEnvironmental ChemistryEnvironmental scienceEcosystem0105 earth and related environmental sciences
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Intestinal absorption pathway of gamma-aminobutyric acid in rat small intestine.

1994

Intestinal absorption of gamma-aminobutyric acid (GABA), as a model compound for gamma-aminoacids, has not been extensively studied from the kinetic viewpoint. Since data from our laboratory suggested that some competition arises between intestinal absorption of beta-alanine and GABA and since our intent was to maintain the aqueous stagnant diffusion layer in order to approach absorption tests to in vivo physiological conditions, a rat jejunum in situ study was undertaken in order to gain an insight into the mechanism of GABA absorption. In the present paper, results from assays using isotonic perfusion solutions with starting GABA concentrations ranging from 1 to 50 mM are reported. They s…

Absorption (pharmacology)MalePharmaceutical ScienceMichaelis–Menten kineticsAminobutyric acidIntestinal absorptionDiffusionNon-competitive inhibitionBody WaterIn vivoIntestine SmallmedicineAnimalsPharmacology (medical)Rats WistarChromatography High Pressure Liquidgamma-Aminobutyric AcidPharmacologyAlanineChemistryGeneral MedicineMembrane transportSmall intestineRatsmedicine.anatomical_structureSpectrometry FluorescenceBiochemistryIntestinal AbsorptionBiophysicsBiopharmaceuticsdrug disposition
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Effect of simulated gastrointestinal digestion on plant sterols and their oxides in enriched beverages

2013

Abstract This study evaluates the bioaccessibility (percentage of soluble compound available for absorption) of plant sterols (PS) and their oxides (phytosterol oxidation products, POPs) after simulated gastrointestinal digestion in fruit (Fb), milk (M) and fruit-based milk beverages with (FbM a ) or without (FbM b ) tangerine juice. In beverages and their bioaccessible fraction (BF), campesterol, campestanol, stigmasterol, β-sitosterol and sitostanol were detected. Bioaccessibility of total PS ranged between 2.62 and 6.48%, FbM b yielding the highest value, followed by FbM a  > Fb > M. Campesterol/campestanol were the most bioaccessible PS. Only oxides of β-sitosterol were detected in beve…

Absorption (pharmacology)StigmasterolChromatographyCampesterolPhytosterolBEVERAGESCampestanolPLANT STEROLchemistry.chemical_compoundchemistryPLANT STEROL; SIMULATED GASTROINTESTINAL DIGESTION; STEROL OXIDATION PRODUCTS; BEVERAGESFood scienceGas chromatography–mass spectrometrySolubilitySIMULATED GASTROINTESTINAL DIGESTIONPlant sterolsSTEROL OXIDATION PRODUCTSFood Science
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Regioselective Hydrogenation of a 60-Carbon Nanographene Molecule toward a Circumbiphenyl Core.

2019

Regioselective peripheral hydrogenation of a nanographene molecule with 60 contiguous sp2 carbons provides unprecedented access to peralkylated circumbiphenyl (1). Conversion to the circumbiphenyl core structure was unambiguously validated by MALDI-TOF mass spectrometry, NMR, FT-IR, and Raman spectroscopy. UV–vis absorption spectra and DFT calculations demonstrated the significant change of the optoelectronic properties upon peripheral hydrogenation. Stimulated emission from 1, observed via ultrafast transient absorption measurements, indicates potential as an optical gain material.

Absorption spectroscopyChemistryCommunicationChemistry (all)RegioselectivityGeneral Chemistry010402 general chemistryMass spectrometryPhotochemistryCatalysis; Chemistry (all); Biochemistry; Colloid and Surface Chemistry01 natural sciencesBiochemistryCatalysis0104 chemical sciencesCatalysissymbols.namesakeColloid and Surface ChemistryUltrafast laser spectroscopysymbolsMoleculeStimulated emissionRaman spectroscopyJournal of the American Chemical Society
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On the Low-Lying Excited States ofsym-Triazine-Based Herbicides

2005

We report a joint computational and luminescence study on the low-lying excited states of sym-triazines, namely, 1,3,5-triazine (1) and the ubiquitous herbicides atrazine [6-chloro-N2-ethyl-N4-isopropyl-1,3,5-triazine-2,4-diamine (2)] and ametryn [6-methylthio-N2-ethyl-N4-isopropyl-1,3,5-triazine-2,4-diamine (3)]. Geometrical structures, energetics, and transition and state properties of I and 2 were computed at the TD-DFT, CASSCF, and CASPT2 levels of theory. The fluorescence and phosphorescence emission spectra, lifetimes, and fluorescence quantum yields were measured for the three compounds, and from these, the energies of the lowest excited states and their corresponding radiative rates…

Absorption spectroscopyQuantum yieldPhotochemistryMolecular physicsAbsorptionAb initio quantum chemistry methodsOscillometryPressureRadiative transferEmission spectrumPhysical and Theoretical ChemistryMolecular StructureChemistry PhysicalHerbicidesTriazinesChemistryTemperatureHydrogen-Ion ConcentrationModels TheoreticalAtomic and Molecular Physics and OpticsSpectrometry FluorescenceModels ChemicalSpectrophotometryExcited stateAtrazineIndicators and ReagentsPhosphorescenceLuminescenceSoftwareChemPhysChem
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Ag11(SG)7 : A New Cluster Identified by Mass Spectrometry and Optical Spectroscopy

2014

We report a one-step and high yield synthesis of a red-luminescent silver cluster with the molecular formula, Ag11(SG)7 (SG: glutathionate) via reduction of silver ions by sodium borohydride in the presence of the tripeptide, glutathione (GSH). The as-prepared cluster shows prominent absorption features at 485 and 625 nm in its UV-vis absorption spectrum. Aging of the as-prepared cluster solution led to the disappearance of the 625 nm peak, followed by broadening of the 485 nm peak to give three maxima at ?487, 437, and 393 nm in its absorption spectrum. These peaks remain unchanged even after polyacrylamide gel electrophoresis (PAGE), where a single band was observed confirming high purity…

Absorption spectroscopyta114Electrospray ionizationAnalytical chemistryMass spectrometryAbsorption spectra; Density functional theory; Electrodeposition; Electromagnetic wave absorption; Electrophoresis; Electrospray ionization; Isotopes; Light absorption; Mass spectrometry; Metal ions; Potable water; Spectrometry; Ultraviolet spectroscopy; Absorption features; Electrospray ionization mass spectrometry; High yield synthesis; Molecular formula; Optical spectroscopy; Polyacrylamide gel electrophoresis; Sodium boro hydrides; UV-VIS absorption spectra; Absorption spectroscopySurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsIonSodium borohydridechemistry.chemical_compoundGeneral EnergyUltraviolet visible spectroscopychemistryPhysical and Theoretical ChemistryAbsorption (electromagnetic radiation)Spectroscopyta116Journal of Physical Chemistry C
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Comparison of novel and conventional calibration techniques for the analysis of urine samples using plasma source mass spectrometry combined with a n…

2012

The accuracy and precision of the analytical data from the analysis of liquid samples with high matrix load often suffer from a compromised performance of the sample introduction system. This is especially significant in the case of miniaturized, pneumatic low flow nebulizers. Alternative low-flow sampling devices based on different operating principles are imperative to overcome this drawback. The superior performance of such an alternative liquid sample introduction system for ICP-MS, the drop-on-demand (DOD) aerosol generator based on thermal inkjet technology, was recently outlined by the same group for the analysis of aqueous standard solutions. Current improvements of the system now a…

Accuracy and precisionChemistrybusiness.industryPlasma source mass spectrometryDrop (liquid)NozzleAnalytical chemistryStandard solutionAnalytical ChemistryMatrix (chemical analysis)Aerosol generatorOn demandProcess engineeringbusinessSpectroscopyJournal of Analytical Atomic Spectrometry
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Fluorimetric determination of amphetamine in urine by flow injection with on-line liquid–liquid extraction

2001

Abstract Determination of amphetamine in urine was performed by batch and flow injection methodologies. The suitable experimental conditions for fluorimetric measurements were established. The liquid–liquid extraction was carried out at pH 13 using diethyl ether as extracting reagent. The measurement conditions were 260 nm and 277 nm for excitation and emission wavelengths, respectively. The method requires standard addition calibration and Youden blank correction. The influence of the main metabolites of amphetamine and metamphetamine were studied. The accuracy and precision of the proposed method was tested and the method is adapted to the flow injection procedure with on-line extraction.

Accuracy and precisionChromatographyInjection ProcedureExtraction (chemistry)Fluorescence spectrometryAnalytical chemistryAnalytical Chemistrychemistry.chemical_compoundchemistryLiquid–liquid extractionReagentStandard additionDiethyl etherSpectroscopyMicrochemical Journal
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