Search results for "Spheres"

Linear Approximation Property, Minkowski Dimension, and Quasiconformal Spheres

1990

The 2009 Edition of the GEISA Spectroscopic Database

2011

The updated 2009 edition of the spectroscopic database GEISA (Gestion et Etude des Informations Spectroscopiques Atmosphériques; Management and Study of Atmospheric Spectroscopic Information) is described in this paper. GEISA is a computer-accessible system comprising three independent sub-databases devoted, respectively, to: line parameters, infrared and ultraviolet/visible absorption cross-sections, microphysical and optical properties of atmospheric aerosols. In this edition, 50 molecules are involved in the line parameters sub-database, including 111 isotopologues, for a total of 3,807,997 entries, in the spectral range from 10-6 to 35,877.031cm-1.The successful performances of the new …

GJ 357 b: A Super-Earth Orbiting an Extremely Inactive Host Star

2020

Aims. In this paper we present a deep X-ray observation of the nearby M dwarf GJ 357 and use it to put constraints on the atmospheric evolution of its planet, GJ 357 b. We also analyse the systematic errors in the stellar parameters of GJ 357 in order to see how they affect the perceived planetary properties. Methods. By comparing the observed X-ray luminosity of its host star, we estimate the age of GJ 357 b as derived from a recent XMM-Newton observation (log Lx [erg s-1] = 25.73), with Lx-age relations for M dwarfs. We find that GJ 357 presents one of the lowest X-ray activity levels ever measured for an M dwarf, and we put a lower limit on its age of 5 Gyr. Using this age limit, we perf…

ARES. III. Unveiling the Two Faces of KELT-7 b with HST WFC3

2020

We present the analysis of the hot-Jupiter KELT-7b using transmission and emission spectroscopy from the Hubble Space Telescope (HST), both taken with the Wide Field Camera 3 (WFC3). Our study uncovers a rich transmission spectrum which is consistent with a cloud-free atmosphere and suggests the presence of H2O and H-. In contrast, the extracted emission spectrum does not contain strong absorption features and, although it is not consistent with a simple blackbody, it can be explained by a varying temperature-pressure profile, collision induced absorption (CIA) and H-. KELT-7 b had also been studied with other space-based instruments and we explore the effects of introducing these additiona…

The GAPS Programme with HARPS-N at TNG: . Atmospheric Rossiter-McLaughlin effect and improved parameters of KELT-9b

2019

In the framework of the GAPS project, we observed the planet-hosting star KELT-9 (A-type star, VsinI$\sim$110 km/s) with the HARPS-N spectrograph at the TNG. In this work we analyse the spectra and the extracted radial velocities (RVs), to constrain the physical parameters of the system and to detect the planetary atmosphere of KELT-9b. We extracted from the high-resolution optical spectra the mean stellar line profiles with an analysis based on the Least Square Deconvolution technique. Then, we computed the stellar RVs with a method optimized for fast rotators, by fitting the mean stellar line profile with a purely rotational profile instead of using a Gaussian function. The new spectra an…

Volcanic plume and bomb field masses from thermal infrared camera imagery

2013

International audience; Masses erupted during normal explosions at Stromboli volcano (Italy) are notoriously difficult to measure. We present a method that uses thermal infrared video for cooling bomb fields to obtain the total power emitted by all hot particles emitted during an explosion. A given mass of magma (M) will emit a finite amount of thermal power, defined by M cp(Te−T0), cp and Te being magma specific heat capacity and temperature, and T0 being ambient temperature. We use this relation to convert the total power emitted by the bomb field to the mass required to generate that power. To do this we extract power flux curves for the field and integrate this through time to obtain to…

Uptake of polyphosphate microparticles in vitro (SaOS-2 and HUVEC cells) followed by an increase of the intracellular ATP pool size

2017

Recently two approaches were reported that addressed a vitally important problem in regenerative medicine, i. e. the successful treatment of wounds even under diabetic conditions. Accordingly, these studies with diabetic rabbits [Sarojini et al. PLoS One 2017, 12(4):e0174899] and diabetic mice [Müller et al. Polymers 2017, 9, 300] identified a novel (potential) target for the acceleration of wound healing in diabetes. Both studies propose a raise of the intracellular metabolic energy status via exogenous administration either of ATP, encapsulated into lipid vesicles, or of polyphosphate (polyP) micro-/nanoparticles. Recently this physiological polymer, polyP, was found to release metabolic …

Cyclin-Dependent Kinase 4 Regulates Adult Neural Stem Cell Proliferation and Differentiation in Response to Insulin

2017

Abstract Insulin is one of the standard components used to culture primary neurospheres. Although it stimulates growth of different types of cells, the effects of insulin on adult neural stem cells (NSCs) have not been well characterized. Here, we reveal that insulin stimulates proliferation, but not survival or self-renewal, of adult NSCs. This effect is mediated by insulin receptor substrate 2 (IRS2) and subsequent activation of the protein kinase B (or Akt), leading to increased activity of the G1-phase cyclin-dependent kinase 4 (Cdk4) and cell cycle progression. Neurospheres isolated from Irs2-deficient mice are reduced in size and fail to expand in culture and this impaired proliferati…

Conformational dynamics of a single protein monitored for 24 hours at video rate

2018

We use plasmon rulers to follow the conformational dynamics of a single protein for up to 24 h at a video rate. The plasmon ruler consists of two gold nanospheres connected by a single protein linker. In our experiment, we follow the dynamics of the molecular chaperone heat shock protein 90 (Hsp90), which is known to show “open” and “closed” conformations. Our measurements confirm the previously known conformational dynamics with transition times in the second to minute time scale and reveals new dynamics on the time scale of minutes to hours. Plasmon rulers thus extend the observation bandwidth 3–4 orders of magnitude with respect to single-molecule fluorescence resonance energy transfer a…

Pharmacokinetics of a sustained release formulation of PDGFβ-receptor directed carrier proteins to target the fibrotic liver

2018

Liver fibrogenesis is associated with excessive production of extracellular matrix by myofibroblasts that often leads to cirrhosis and consequently liver dysfunction and death. Novel protein-based antifibrotic drugs show high specificity and efficacy, but their use in the treatment of fibrosis causes a high burden for patients, since repetitive and long-term parenteral administration is required as most proteins and peptides are rapidly cleared from the circulation. Therefore, we developed biodegradable polymeric microspheres for the sustained release of proteinaceous drugs. We encapsulated the drug carrier pPB-HSA, which specifically binds to the PDGF beta R that is highly upregulated on a…