Search results for "Spinal"

TAFA4 relieves injury-induced mechanical hypersensitivity through LDL receptors and modulation of spinal A-type K+ current

2021

Pain, whether acute or persistent, is a serious medical problem worldwide. However, its management remains unsatisfactory, and new analgesic molecules are required. We show here that TAFA4 reverses inflammatory, postoperative, and spared nerve injury (SNI)-induced mechanical hypersensitivity in male and female mice. TAFA4 requires functional low-density lipoprotein receptor-related proteins (LRPs) because their inhibition by RAP (receptor-associated protein) dose-dependently abolishes its antihypersensitive actions. SNI selectively decreases A-type K+ current (IA) in spinal lamina II outer excitatory interneurons (L-IIo ExINs) and induces a concomitant increase in IA and decrease in hyperpo…

Fractional Calculus as a New Perspective in the Viscoelastic Behaviour of the Intervertebral Disc

2022

The spinal column is the load-bearing structure of the human being along with its components, which together build a strong, resistant, and stable structure, but there are a few different pathologies from which it can suffer, such as herniated discs. The intervertebral disc acts as a shock absorber and ensures the spine’s great capacity to support high loads and different states of stress, thanks to its viscoelastic properties. Some studies have attempted to describe the viscoelastic behaviour of the intervertebral disc using classical rheological models, such as the Kelvin-Voigt, or multi-parameter models. Even if these models partially describe the viscoelastic response of disc, all visco…

RHEUMATOID ARTHRITIS INDUCED BY INTRA-ARTICULAR INJECTION OF COMPLETE FREUND’S ADJUVANT ALTERS THE EXPRESSION OF VARIOUS HSPS IN THE DIFFERENT REGION…

2023

Correlation between Topographic Parameters Obtained by Back Surface Topography Based on Structured Light and Radiographic Variables in the Assessment…

2017

<sec><title>Study Design</title><p>Optical cross-sectional study.</p></sec><sec><title>Purpose</title><p>To study the correlation between asymmetry of the back (measured by means of surface topography) and deformity of the spine (quantified by the Cobb angle).</p></sec><sec><title>Overview of Literature</title><p>The Cobb angle is considered the gold standard in diagnosis and follow-up of scoliosis but does not correctly characterize the three-dimensional deformity of scoliosis. Furthermore, the exposure to ionizing radiation may cause harmful effects particularly during the growth stage, includi…

Effets aigus et chroniques de l’électrostimulation appliquée au niveau du nerf moteur : importance du retour afférent

2019

The aim of this thesis was to investigate the effects of electrical stimulation protocols favouring an indirect motor units’ (MU) recruitment via sensory axons activation and giving rise to extra force development, on the neuromuscular system. These protocols use wide pulse duration, low stimulation intensity, low and high stimulation frequencies and are applied over the motor nerve. The aim of the first study was to examine the effects of these protocols on the extent and origin of neuromuscular fatigue during an acute application. Results showed that for a similar impact on maximal force generating capacity, low stimulation frequencies limit force decreases during the stimulation trains a…

The Italian observational study on severe osteoporosis (ISSO): 24-month results on incidence of fractures and adherence to treatment

2016

Objective To estimate the proportion of patients with very severe osteoporosis (those covered by the reimbursement criteria of the Italian National Health Service) experiencing new vertebral and non-vertebral fragility fractures in the first 24 months of a new anti-osteoporosis treatment. Methods Prospective observational study in men and post-menopausal women (aged > 21 years) initiating anti-osteoporosis treatment for very severe osteoporosis. Eligibility was based on teriparatide (TPD) reimbursement criteria in Italy: Incident of vertebral or hip fracture during anti-resorptive treatment (minimum 1 year), or at least three prevalent severe vertebral fractures, or two prevalent severe ver…

Influence of complex physiotherapy on the functional condition of the spine in older people

2018

The aim of the present study was to assess the impact of 21-days comprehensive physiotherapy program on the functional condition of the spine and severity of pain in older people. To achieve this goal, physiotherapeutic procedures were performed on 100 elderly patients suffering from spinal disorders. The comprehensive therapy program consisted of: general improvement exercises, individual exercises with a physiotherapist, exercises in water and physical therapy treatments such as: TENS currents, galvanic current, iontophoresis, laser stimulation, magnetic field on the lumbar spine and hydro massage or mud compresses. Prior and post the therapy program: the Schober’s test - 1 (forward flexi…

Neurophysiological studies of pain pathways in peripheral and central nervous system disorders.

2003

Standard clinical neurophysiological assessment of somatosensory pathways by sensory evoked potentials (SEPs) is limited to the tactile and proprioceptive systems consisting of large fibers in the peripheral nerve, the dorsal columns of the spinal cord and the medial lemniscus in the brainstem. This limitation means that about half of the lesions in the somatosensory system will not be detectable. In recent years, many clinical studies have confirmed that laser evoked potentials (LEPs) allow the assessment of the other half of the somatosensory system. Rapid heating of the skin by infrared laser pulses specifically activates the nociceptive and thermoreceptive pathways consisting of small f…

Treatment algorithm for spontaneous spinal infections: A review of the literature

2019

Background: Primary spinal infections are rare pathologies with an estimated incidence of 5% of all osteomyelitis. The diagnosis can be challenging and this might result in a late identification. The etiological diagnosis is the primary concern to determine the most appropriate treatment. The aim of this review article was to identify the importance of a methodological attitude toward accurate and prompt diagnosis using an algorithm to aid on spinal infection management. Methods: A search was done on spinal infection in some databases including PubMed, ISI Web of Knowledge, Google Scholar, Ebsco, Embasco, and Scopus. Results: Literature reveals that on the basis of a clinical suspicion, the…

Spontaneous spinal discitis and spondylodiscitis: Clinicotherapeutic remarks

2017

Spinal infections are rare (their incidence is estimated in about the 5% of all osteomyelitis) and severe pathologies. They are usually identified with different names, as disk space infection, spondylodiscitis, and vertebral osteomyelitis. Spondylodiscitis is the most frequent among spinal infections. The etiology might be due to bacteria, fungi, and parasites and might affect many anatomical structures. The reported incidence is increased in the last years.[1,2] The disease can be classified according to the involved anatomical structure: Vertebral osteomyelitis Discitis and spondylodiscitis Spinal canal infections Adjacent soft tissue infections. In adult patients, the terms osteomyeliti…