Search results for "Stability."
showing 10 items of 3015 documents
The mRNA degradation factor Xrn1 regulates transcription elongation in parallel to Ccr4
2019
Abstract Co-transcriptional imprinting of mRNA by Rpb4 and Rpb7 subunits of RNA polymerase II (RNAPII) and by the Ccr4–Not complex conditions its post-transcriptional fate. In turn, mRNA degradation factors like Xrn1 are able to influence RNAPII-dependent transcription, making a feedback loop that contributes to mRNA homeostasis. In this work, we have used repressible yeast GAL genes to perform accurate measurements of transcription and mRNA degradation in a set of mutants. This genetic analysis uncovered a link from mRNA decay to transcription elongation. We combined this experimental approach with computational multi-agent modelling and tested different possibilities of Xrn1 and Ccr4 acti…
Familial risk-colorectal cancer: ESMO Clinical Practice Guidelines.
2013
J. Balmana1, F. Balaguer2, A. Cervantes3 & D. Arnold4, on behalf of the ESMO Guidelines Working Group* Department of Medical Oncology, Hospital Vall d’Hebron, Vall d’Hebron Institute of Oncology (VHIO), Universitat Autonoma de Barcelona, Barcelona; Department of Gastroenterology, Hospital Clinic, CIBERehd, IDIBAPS, University of Barcelona, Barcelona; Department of Hematology and Medical Oncology, INCLIVA, University of Valencia, Valencia, Spain; Department of Medical Oncology, Tumor Biology Clinic, Albert Ludwigs University, Freiburg, Germany;
Incidence du passage obligatoire aux normes comptables IAS / IFRS sur le risque d'instabilité bancaire
2011
In this thesis, we study the economic consequences, in terms of instability, of the mandatory IAS/IFRS adoption in the banking industry. The thesis is organized as follows. In a first part (Chapter I), we develop a theoretical framework whose purpose is to understand the mechanisms through which the mandatory IAS/IFRS adoption by banks may influence the probability of occurrence of a banking crisis. At this stage, we show that several arguments, derived from the contractual and informational perspectives of accounting, can be mobilized in order to justify the hypothesis that the mandatory IAS/IFRS adoption has a positive or a negative influence on banking stability. The second part of the t…
Personality correlates and gender invariance of wording effects in the German version of the Rosenberg Self-Esteem Scale
2016
The Rosenberg Self-Esteem Scale (RSES) is designed to provide an evaluation of one's self-worth. Investigations on the dimensionality of the RSES do not result in simple unifactorial solutions. The direction of the item wording has been suggested as a reason for the contamination of its factorial structure. Latent factor approaches allow for the modeling of method effects, and, particularly in bifactor models, configurations with substantive as well as additional specific factors can be specified. This paper analyzes data from a longitudinal survey in Germany. A bifactor solution with one substantive and two specific factors related to positive and negative wording performs best out of ten …
Pulsations in the late-type Be star HD 50 209 detected by CoRoT
2009
The presence of pulsations in late-type Be stars is still a matter of controversy. It constitutes an important issue to establish the relationship between non-radial pulsations and the mass-loss mechanism in Be stars. To contribute to this discussion, we analyse the photometric time series of the B8IVe star HD 50209 observed by the CoRoT mission in the seismology field. We use standard Fourier techniques and linear and non-linear least squares fitting methods to analyse the CoRoT light curve. In addition, we applied detailed modelling of high-resolution spectra to obtain the fundamental physical parameters of the star. We have found four frequencies which correspond to gravity modes with az…
AQM generalized nyquist stability in multiple bottleneck networks
2005
Abstract The influence of multiple bottlenecks on the stability of Active Queue Management (AQM) controllers, usually configured on a single bottleneck basis is discussed. We consider a network scenario where RED is configured at each router according to previously developed control theoretic techniques. These configuration rules assure stability in a single bottleneck scenario. We show that instability may arise when two links become congested. We justify this result through a multiple bottleneck model using the Generalized Nyquist stability criterion.
About the stability of active queue management mechanisms
2004
In this paper, we discuss the influence of multiple bottlenecks on the stability of active queue management (AQM) controllers, usually configured on a single bottleneck basis. To see this, we consider a network scenario where RED is configured at each router according to previously developed control theoretic techniques. These configuration rules assure stability in a single bottleneck scenario. Yet, we show that instability may arise when two links become congested. We justify this result through a multiple bottleneck model.
Computer networks stability independence of the queuing delays
2015
Communication in intelligent computer networks is an indispensible attribute of the dataflow quality in Web traffic. We propose a model that investigates intelligent computer networks stability while specifying its limits. Packet queuing delay affects the performance of the network, and especially its stability. If the network is presented as a dynamic system in block diagram form, we compute a transfer function and determine the quasi-polynomial system. The characteristic polynomial distribution of zeros of complex variable quasi-plane determines the boundaries of the network stability. The approach relies on estimation of the network system's transfer functions and its quasi-polynomial. C…
A Discrete Model for a Network Having Broken Packages
2009
Broken packages are packages with not enough information regarding the destination address and they have a negative impact on a computer network. Broken packages stay in the router too much time and overload it. This is a real problem which appears in the computer network of Sofia University. We know only the time when a broken package arrives in the router. The problem is to find the computer which send broken packages. The aim of this article is to propose a model for defining the data transmission stability and correctness in a computer network. Our theoretical model is temporal dependent and captures the transmission properties of a computer network.
Avian Clock gene polymorphism: evidence for a latitudinal cline in allele frequencies
2007
In comparison with most animal behaviours, circadian rhythms have a well-characterized molecular genetic basis. Detailed studies of circadian clock genes in 'model' organisms provide a foundation for interpreting the functional and evolutionary significance of polymorphic circadian clock genes found within free-living animal populations. Here, we describe allelic variation in a region of the avian Clock orthologue which encodes a functionally significant polyglutamine repeat (ClkpolyQcds), within free-living populations of two passerine birds, the migratory bluethroat (Luscinia svecica) and the predominantly nonmigratory blue tit (Cyanistes caeruleus). Multiple ClkpolyQcds alleles were foun…