Search results for "Stability."

In the literature: April 2020

2020

Deficient DNA mismatch repair (dMMR) may be caused by germline or somatic mutations in mismatch repair genes ( MLH1 , MSH2 , MSH3 , MSH6 and PMS2 ) or through epigenetic silencing of MLH1 .1 dMMR induces a hypermutator phenotype, also known as microsatellite instability (MSI). Next-generation sequencing identifies MSI in 12 cancer types. The highest prevalence is seen in endometrial cancer (31.4%), followed by colorectal cancer (19.7%) and gastric cancer (GC, 19.1%). MSI was related to better prognosis for colorectal cancer and GC . Moreover, the dMMR/MSI hypermutator phenotype is thought to produce large numbers of immunogenic neoantigens that can be recognised by immune cells, leading to …

Correction: Daunorubicin reduces MBNL1 sequestration caused by CUG-repeat expansion and rescues cardiac dysfunctions in a Drosophila model of myotoni…

2018

ABSTRACT Myotonic dystrophy (DM) is a dominantly inherited neuromuscular disorder caused by expression of mutant myotonin-protein kinase (DMPK) transcripts containing expanded CUG repeats. Pathogenic DMPK RNA sequesters the muscleblind-like (MBNL) proteins, causing alterations in metabolism of various RNAs. Cardiac dysfunction represents the second most common cause of death in DM type 1 (DM1) patients. However, the contribution of MBNL sequestration in DM1 cardiac dysfunction is unclear. We overexpressed Muscleblind (Mbl), the Drosophila MBNL orthologue, in cardiomyocytes of DM1 model flies and observed a rescue of heart dysfunctions, which are characteristic of these model flies and resem…

Robust delay-dependent H∞ control of uncertain time-delay systems with mixed neutral, discrete, and distributed time-delays and Markovian switching p…

2011

Author's version of an article published in the journal: IEEE Transactions on Circuits and Systems I: Regular Papers. Also available from the publisher at: http://dx.doi.org/10.1109/tcsi.2011.2106090 The problem of robust mode-dependent delayed state feedback H ∞ control is investigated for a class of uncertain time-delay systems with Markovian switching parameters and mixed discrete, neutral, and distributed delays. Based on the LyapunovKrasovskii functional theory, new required sufficient conditions are established in terms of delay-dependent linear matrix inequalities for the stochastic stability and stabilization of the considered system using some free matrices. The desired control is …

Regionalization processes in agricultural and environmental policies. A regional typologies comparative analysis to identifying fragile areas

2018

This paper, affecting an analysis comparative of the different regional typologies, it analyzes the concept of weakness, with reference to the phenomena of degrade and disarrangement of the grounds, inside the processes of identification of functional territorial articulations to the statistical analysis and the decisions of policy, showing as despite the existence of a fed together of interpretations none of the examined typologies both indeed able to furnish a representation suitable of the phenomenon, since the different procedures of regionalization introduce not suitable discriminatory methodologies.

Volume I. Introduction to DUNE

2020

Journal of Instrumentation 15(08), T08008 (1-228) (2020). doi:10.1088/1748-0221/15/08/T08008

Stability and oscillation of dynamical systems : theory and applications

2008

Generalized heat equation and transitions between different heat-transport regimes in narrow stripes

2019

Abstract In the framework of weakly nonlocal thermodynamic theory, in this paper we derive a nonlocal and nonlinear heat-transport equation beyond the Fourier law by means of thermodynamic considerations in agreement with the second law. The obtained equation describes the transitions among different heat-transport regimes. The stability of the solution of that equation is also analyzed in a special case.

Inter-area oscillations in the 500-kV Vietnamese power system

2019

The paper presents the study of the 500-kV Vietnamese power system. The oscillatory response of the system is analyzed both with a modal analysis and a time domain analysis. The 500-kV system of Vietnam is modeled in details, including all the power plants with the corresponding regulators. The model is developed in collaboration with the Institute of Energy Science IES-VAST of Vietnam and it is validated with the data provided by the National Load Dispatch Centre (NLDC) of Vietnam. The simulation results reveal a clear identification of potential inter-area oscillations between North and South of the Country. A worsening of the observed phenomenon should be considered as possible, especial…

Transient stability simulation of a fixed speed wind turbine by Matlab/Simulink

2007

This paper describes the dynamic behavior of a typical fixed speed wind turbine connected to the grid; the model is developed in the simulation tool Matlab/Simulink and created as a modular structure. The pitch control system is used for stabilization of the wind turbine at grid faults. In this way, voltage stability of the system with grid-connected wind turbines can be improved by using blade-angle control for a temporary reduction of the wind turbine power during a short-circuit fault in the grid. This paper shows a new variable control for maintaining of voltage stability, when a three-phase fault is applied close to the wind turbine and cleared by disconnecting the affected line. In th…

On hidden heterogeneity in directional asymmetry – can systematic bias be avoided?

2006

8 pages; International audience; Directional asymmetry (DA) biases the analysis of fluctuating asymmetry (FA) mainly because among-individual differences in the predisposition for DA are difficult to detect. However, we argue that systematic bias mainly results from predictable associations between signed right-left asymmetry and other factors, i.e. from systematic variation in DA. We here demonstrate methods to test and correct for this, by analysing bilateral asymmetry in size and shape of an irregular sea urchin. Notably, in this model system, DA depended significantly on body length and geographic origin, although mean signed asymmetry (mean DA) was not significant in the sample as a wh…