Search results for "Stability."
showing 10 items of 3015 documents
Role of the Non-Canonical RNAi Pathway in the Antifungal Resistance and Virulence of Mucorales
2021
Mucorales are the causal agents for the lethal disease known as mucormycosis. Mortality rates of mucormycosis can reach up to 90%, due to the mucoralean antifungal drug resistance and the lack of effective therapies. A concerning urgency among the medical and scientific community claims to find targets for the development of new treatments. Here, we reviewed different studies describing the role and machinery of a novel non-canonical RNAi pathway (NCRIP) only conserved in Mucorales. Its non-canonical features are the independence of Dicer and Argonaute proteins. Conversely, NCRIP relies on RNA-dependent RNA Polymerases (RdRP) and an atypical ribonuclease III (RNase III). NCRIP regulates the…
Unveiling the oxidation behavior of liquid-phase exfoliated antimony nanosheets
2020
Abstract Antimonene, a monolayer of β-antimony, is increasingly attracting considerable attention, more than that of other monoelemental two-dimensional materials, due to its intriguing physical and chemical properties. Under ambient conditions, antimonene exhibits a high thermodynamic stability and good structural integrity. Some theoretical calculations predicted that antimonene would have a high oxidation tendency. However, it remains poorly investigated from the experimental point of view. In this work, we study the oxidation behavior of antimonene nanosheets (ANS) prepared by ultrasonication-assisted liquid-phase exfoliation. Using a set of forefront analytical techniques, a clear effe…
Oxidative stability of virgin olive oils
2001
An investigation was carried out on virgin olive oils of the Gentile (Larino), Gentile (Colletorto), Coratina, and Leccino varieties, harvested at different times, to assess their oxidation stability. The olive oils were analyzed by means of peroxide, K-232, and K 270 values at 1, 6, 12, and 18 mon of storage in green bottles, in the dark, at temperatures ranging from a mean of 6degreesC in winter to 12degreesC in summer. A subsample was also oven-tested at 75degreesC and then analyzed on a weekly basis using the same oxidative parameters. The less ripe the olives (harvested in the same area, during 1 mon), the more resistant the olive oils were to forced oxidation. The amount of total phen…
Delivery of liquorice extract by liposomes and hyalurosomes to protect the skin against oxidative stress injuries.
2015
Liquorice extract, obtained by percolation in ethanol of Glycyrrhiza glabra L. roots, was incorporated in liposomes and hyalurosomes, new phospholipid-sodium hyaluronate vesicles, and their protective effect against oxidative stress skin damages was probed. As a comparison, raw glycyrrhizin was also tested. All the vesicles were small in size (≤ 100 nm), with a highly negative zeta potential ensuring long-term stability, and able to incorporate a high amount of the extract. In vitro tests showed that the liquorice extract loaded in vesicles was able to scavenge DPPH free radical (80% inhibition) and to protect 3T3 fibroblasts against H2O2-induced oxidative stress, restoring the normal condi…
In vitro digestion of betalainic foods. Stability and bioaccessibility of betaxanthins and betacyanins and antioxidative potential of food digesta.
2008
Betalains are considered to be bioactive dietary phytochemicals. The stability of betacyanins and betaxanthins from either fresh foods or manufactured products of cactus pear fruit ( Opuntia ficus indica L. Mill. cv. Gialla and Rossa) and red beet ( Beta vulgaris L. ssp. vulgaris) was assessed in a simulated oral, gastric, and small intestinal digestion and compared with the digestive stability of purified pigments. A minor loss of indicaxanthin, at the gastric-like environment only, and a decrease of vulgaxanthin I through all digestion steps were observed, which was not affected by food matrix. In contrast, food matrix prevented decay of betanin and isobetanin at the gastric-like environm…
Resonance frequency analysis after the placement of 133 dental implants
2006
Introducción: La estabilidad primaria del implante dental está relacionada con el hueso que se encuentra en contacto con él y se puede medir mediante el análisis de frecuencia de resonancia. Material y métodos: En 133 implantes (62 en maxilar y 71 en mandíbula) se midió la frecuencia de resonancia y la fuerza de inserción para conocer la estabilidad de los implantes el día de la cirugía, y estudiar su relación con distintas variables. Resultados: El cociente de estabilidad del implante obtenido el día de la cirugía fue de 62’1 y el de la fuerza de inserción fue de 35’7 Nw. La fuerza de inserción fue proporcional al análisis de la frecuencia de resonancia, a mayor fuerza de inserción mayor c…
Controlling protein interactions in blood for effective liver immunosuppressive therapy by silica nanocapsules
2020
Immunosuppression with glucocorticoids is a common treatment for autoimmune liver diseases and after liver transplant, which is however associated with severe side-effects. Targeted delivery of glucocorticoids to inflammatory cells, e.g. liver macrophages and Kupffer cells, is a promising approach for minimizing side effects. Herein, we prepare core–shell silica nanocapsules (SiO2 NCs) via a sol–gel process confined in nanodroplets for targeted delivery of dexamethasone (DXM) for liver immunosuppressive therapy. DXM with concentrations up to 100 mg mL−1 in olive oil are encapsulated while encapsulation efficiency remains over 95% after 15 days. Internalization of NCs by non-parenchymal muri…
Hölder stability for Serrin’s overdetermined problem
2015
In a bounded domain \(\varOmega \), we consider a positive solution of the problem \(\Delta u+f(u)=0\) in \(\varOmega \), \(u=0\) on \(\partial \varOmega \), where \(f:\mathbb {R}\rightarrow \mathbb {R}\) is a locally Lipschitz continuous function. Under sufficient conditions on \(\varOmega \) (for instance, if \(\varOmega \) is convex), we show that \(\partial \varOmega \) is contained in a spherical annulus of radii \(r_i 0\) and \(\tau \in (0,1]\). Here, \([u_\nu ]_{\partial \varOmega }\) is the Lipschitz seminorm on \(\partial \varOmega \) of the normal derivative of u. This result improves to Holder stability the logarithmic estimate obtained in Aftalion et al. (Adv Differ Equ 4:907–93…
Monotonicity-based inversion of the fractional Schr\"odinger equation II. General potentials and stability
2019
In this work, we use monotonicity-based methods for the fractional Schr\"odinger equation with general potentials $q\in L^\infty(\Omega)$ in a Lipschitz bounded open set $\Omega\subset \mathbb R^n$ in any dimension $n\in \mathbb N$. We demonstrate that if-and-only-if monotonicity relations between potentials and the Dirichlet-to-Neumann map hold up to a finite dimensional subspace. Based on these if-and-only-if monotonicity relations, we derive a constructive global uniqueness results for the fractional Calder\'on problem and its linearized version. We also derive a reconstruction method for unknown obstacles in a given domain that only requires the background solution of the fractional Sch…
Coincidence problems for generalized contractions
2014
In this paper, we establish some new existence, uniqueness and Ulam-Hyers stability theorems for coincidence problems for two single-valued mappings. The main results of this paper extend the results presented in O. Mle?ni?e: Existence and Ulam-Hyers stability results for coincidence problems, J. Non-linear Sci. Appl., 6(2013), 108-116. In the last section two examples of application of these results are also given.