Search results for "Stability"

The role of water in hemoglobin function and stability

1993

Heats and Entropies of Reaction of Transition Metal Ions with Ethylenediamine

1960

THE heats of formation of complexes between ligands and metal ions are very important to further the ligand field-theory and check its implications. Until now, only the heats of hydration of the first transition group ions have been used for this purpose1 as the thermochemical data on the complexes formed by ligands other than water are very incomplete. The transition metal complexes of ethylenediamine, which have a very nearly octahedral configuration, could also be fruitfully studied in terms of ligand field-theory. Unfortunately only the thermal data on nickel (II), copper (II) and zinc (II) complexes are known2, and so the formation constants have been used instead of the values of enth…

RNA-controlled nucleocytoplasmic shuttling of mRNA decay factors regulates mRNA synthesis and a novel mRNA decay pathway.

2021

AbstractmRNA level is controlled by factors that mediate both mRNA synthesis and decay, including the 5’ to 3’ exonuclease Xrn1. Here we show that nucleocytoplasmic shuttling of several yeast mRNA decay factors plays a key role in determining both mRNA synthesis and decay. Shuttling is regulated by RNA-controlled binding of the karyopherin Kap120 to two nuclear localization sequences (NLSs) in Xrn1, location of one of which is conserved from yeast to human. The decaying RNA binds and masks NLS1, establishing a link between mRNA decay and Xrn1 shuttling. Preventing Xrn1 import, either by deleting KAP120 or mutating the two Xrn1 NLSs, compromises transcription and, unexpectedly, also cytoplas…

Demyelination patterns in a mathematical model of multiple sclerosis.

2016

In this paper we derive a reaction-diffusion-chemotaxis model for the dynamics of multiple sclerosis. We focus on the early inflammatory phase of the disease characterized by activated local microglia, with the recruitment of a systemically activated immune response, and by oligodendrocyte apoptosis. The model consists of three equations describing the evolution of macrophages, cytokine and apoptotic oligodendrocytes. The main driving mechanism is the chemotactic motion of macrophages in response to a chemical gradient provided by the cytokines. Our model generalizes the system proposed by Calvez and Khonsari (Math Comput Model 47(7–8):726–742, 2008) and Khonsari and Calvez (PLos ONE 2(1):e…

CORPORATE BANKRUPTCY AND INSOLVENCY PREDICTION MODEL

2021

In any competitive economy, the risk of bankruptcy is pervasive. The research aims to contribute in improving the predictive power of bankruptcy and insolvency risk among companies by introducing new methods of processing and validation. This paper investigates the extensive application of the Z score model for predicting the economic-financial stability of Romanian companies in the manufacturing and extractive industries. A list of 37 financial indicators determined on the basis of the balance sheet data of 80 companies for the period 2015–2018 was used. Stepwise Least Squares Estimation through the Forward method allowed the identification of the most relevant ones. Canonical discriminant…

Nonlinear analysis of classical phase-locked loops in signal's phase space

2014

Abstract Discovery of undesirable hidden oscillations, which cannot be found by the standard simulation, in phase-locked loop (PLL) showed the importance of consideration of nonlinear models and development of rigorous analytical methods for their analysis. In this paper for various signal waveforms, analytical computation of multiplier/mixer phase-detector characteristics is demonstrated, and nonlinear dynamical model of classical analog PLL is derived. Approaches to the rigorous nonlinear analysis of classical analog PLL are discussed.

Embedding Quantum into Classical: Contextualization vs Conditionalization

2014

We compare two approaches to embedding joint distributions of random variables recorded under different conditions (such as spins of entangled particles for different settings) into the framework of classical, Kolmogorovian probability theory. In the contextualization approach each random variable is "automatically" labeled by all conditions under which it is recorded, and the random variables across a set of mutually exclusive conditions are probabilistically coupled (imposed a joint distribution upon). Analysis of all possible probabilistic couplings for a given set of random variables allows one to characterize various relations between their separate distributions (such as Bell-type ine…

Prediction of chromatographic properties of organophosphorus insecticides by molecular connectivity

2000

A study is reported of the relationship between theR F values for a group of organophosphorus insecticides obtained by thin layer chromatography and a series of topological descriptors. By using multivariate regression, the corresponding connectivity functions were obtained, which had been selected on the basis of their respective statistical parameters: multiple correlation coefficient (r), standard error of estimate (s), F-Snedecor values and statistical significance (Student’s t). Regression analysis of the connectivity functions can predict the elution behaviour of any structurally similar derivative of this group of compounds with different stationary and mobile phases. Stability studi…

Clustering-Based Algorithm for Connectivity Maintenance in Vehicular Ad-Hoc Networks

2014

International audience; Among recent advances in wireless communication technologies' field, Vehicular Ad-hoc Networks (VANETs) have drawn the attention of both academic and industry researchers due to their potential applications including driving safety, entertainment, emergency applications, and content sharing. VANET networks are characterized by their high mobile topology changes. Clustering is one of the control schemes used to make this global topology less dynamic. It allows the formation of dynamic virtual backbone used to organize the medium access, to support quality of service and to simplify routing. Mainly, nodes are organized into clusters with at least one cluster head (CH) …

Recent Advances of Spin Crossover Research

2004

Thermal spin transition (spin crossover), one of the most fascinating dynamic electronic structure phenomena occurring in coordination compounds of third row transition metal ions, mostly of iron(II), iron(III) and cobalt(II) with critical ligand field strengths competing with the spin pairing energy, has attracted increasing attention by many research groups. One of the reasons is the promising potential for practical applications. In this chapter we intend to cover essential recent work, primarily accomplished within the European research network on "Thermal and Optical Switching of Molecular Spin States (TOSS)". New spin crossover compounds and their thermal spin transition behaviour, al…