Search results for "Stability"
showing 10 items of 3085 documents
Paclitaxel and beta-lapachone synergistically induce apoptosis in human retinoblastoma Y79 cells by downregulating the levels of phospho-Akt.
2009
Paclitaxel (PTX) and beta-lapachone (LPC) are naturally occurring compounds that have shown a large spectrum of anticancer activity. In this article we show for the first time that PTX/LPC combination induces potent synergistic apoptotic effects in human retinoblastoma Y79 cells. Combination of suboptimal doses of PTX (0.3 nM) and LPC (1.5 microM) caused biochemical and morphological signs of apoptosis at 48 h of treatment. These effects were accompanied by potent lowering in inhibitor of apoptosis proteins and by activation of Bid and caspases 3 and 6 with lamin B and PARP breakdown. PTX/LPC combination acted by favoring p53 stabilization through a lowering in p-Akt levels and in ps166-MDM…
Long-term stability study of clofarabine injection concentrate and diluted clofarabine infusion solutions
2011
Purpose: The aim of this study was to investigate the physicochemical stability of clofarabine (CAFdA) injection concentrate and ready-to-use CAFdA infusion solutions over a prolonged period of 28 days. Methods: To determine the stability of CAFdA infusion solutions, the injection concentrate (Evoltra®, 1 mg/mL, Genzyme) was diluted either with 0.9% sodium chloride or 5% glucose infusion solution. The resulting concentrations of 0.2 mg/mL or 0.6 mg/mL, respectively, were chosen to represent the lower and upper limit of the ordinary concentration range. Test solutions were stored under refrigeration (2–8°C) or at room temperature either light protected or exposed to light. CAFdA concentrati…
Coordinated Sumoylation and Ubiquitination Modulate EGF Induced EGR1 Expression and Stability
2011
Background Human early growth response-1 (EGR1) is a member of the zing-finger family of transcription factors induced by a range of molecular and environmental stimuli including epidermal growth factor (EGF). In a recently published paper we demonstrated that integrin/EGFR cross-talk was required for Egr1 expression through activation of the Erk1/2 and PI3K/Akt/Forkhead pathways. EGR1 activity and stability can be influenced by many different post-translational modifications such as acetylation, phosphorylation, ubiquitination and the recently discovered sumoylation. The aim of this work was to assess the influence of sumoylation on EGF induced Egr1 expression and/or stability. Methods We …
Asynchronously switched control of discrete impulsive switched systems with time delays
2013
This paper is concerned with the stabilization problem for a class of uncertain discrete impulsive switched delay systems under asynchronous switching. The so-called asynchronous switching means that the switches between the candidate controllers and system modes are asynchronous. By using the average dwell time (ADT) approach, sufficient conditions for the existence of an asynchronously switched controller is derived such that the resulting closed-loop system is exponentially stable. The desired controller gains and the admissible switching signals are obtained in terms of a set of matrix inequalities. A numerical example is given to illustrate the effectiveness of the proposed method.
Stability analysis of logistics networks with time-delays
2012
Logistics network represents a complex system where different elements that are logistic locations interact with each other. This interaction contains delays caused by time needed for delivery of the material. In this paper, we study local input-to-state stability of such logistics networks. Their behaviour is described by a functional differential equation with a constant time-delay. An appropriate Lyapunov–Razumikhin function and the small gain condition are utilized to establish some conditions for stability analysis of the network under consideration. Our stability conditions for the logistics network are based on the information about the interconnection properties between logistic loc…
Exponential stability analysis of Markovian jump nonlinear systems with mixed time delays and partially known transition probabilities
2013
In this paper, the problem of exponential stability is studied for a class of Markovian jump neutral nonlinear systems with mixed neutral and discrete time delays. By Lyapunov-Krasovskii function approach, a novel mean-square exponential stability criterion is derived for the situation that the system's transition rates are partially or completely accessible. Finally, some numerical examples are provided to illustrate the effectiveness of the proposed methods.
EFFECT OF PROCESSING TEMPERATURE VARIATION ON STORAGE STABILITY OF TIRE RUBBER MODIFIED BINDERS
2012
Tire Rubber Modified Binders (TR-MBs), produced through wet process and used worldwide (e.g. asphalt rubber), have been demonstrated to provide various benefits to pavements and, moreover, represent a good opportunity for recycling tire rubber. However, this technology is still struggling to be fully adopted in Europe, mainly because of the poor stability of TR-MBs during high temperature storage, which leads to high initial costs in modifying existing asphalt plants. No-agitation TR-MBs (also known as terminal blends) are proving to be a great option and their development could also be the key to spreading the use of tire rubber in paving applications in Europe. This paper aims to enrich t…
Properties of titanium dioxide
2021
"Properties of titanium dioxide" presents a survey of the main physicochemical properties of TiO2 upon which rely all of the applications of this material. Structures and morphologies of titanium dioxide have been taken into account, also in correlation with thermodynamic properties. Bulk and surface defectivity has been described in detail, because of its relevant consequences in terms of catalytic activity. The basic mechanisms of interaction between photons and TiO2 have been discussed on the basis of the optoelectronic features of the semiconductor. Finally, electrical, mechanical, and rheological properties of TiO2 have been presented.
Gis-analysis to assess landslide susceptibility in a fluvial basin of NW Sicily (Italy).
2008
Abstract Landslide hazard assessment, effected by means of geostatistical methods, is based on the analysis of the relationships between landslides and the spatial distributions of some instability factors. Frequently such analyses are based on landslide inventories in which each record represents the entire unstable area and is managed as a single instability landform. In this research, landslide susceptibility is evaluated through the study of a variety of instability landforms: landslides, scarps and areas uphill from crown . The instability factors selected were: bedrock lithology, steepness, topographic wetness index and stream power index. The instability landform densities computed f…
A Teaching Experience: Aeroelasticity and the Finite Element Method
2015
[EN] The aeroelastic modelling of aircraft structures is a fundamental area for the students of Aerospace Engineering Degree. This subject has a strongly multidisciplinary character and involves other several subjects like mechanics, vibrations, aerodynamics, structural analysis. Consequently, the students find stimulating the challenge of merging their knowledge at different areas. In this paper, a teaching experience on the solution of the aeroelastic problem of a 3D-wing through six different computer tasks is presented. The main objective is to attempt a relatively complex problem using a simple version of the Finite Element Method with only four degrees of freedom. The students begin c…